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However, side-effects such as polyuria limit its tolerability and thereby the therapeutic potential. This study will test whether co-administration with hydochlorothiazide can improve V2RA efficacy (slowing kidney function decline) and tolerability (quality of life) in ADPKD. Approximately 300 patients will be enrolled.",[318],"ADPKD",[318,320,9,321,322,323],"Tolvaptan","Quality of Life","Side effects","Polyuria","2026-08-12",{"date":326,"type":327},"2026-08-14","ACTUAL",{"date":329,"type":327},"2024-07-31",{"date":331,"type":312},"2031-07",{"name":5,"class":6},22]