[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100656937":3},{"organization":4,"outcomesModule":7,"designInfo":35,"detailedDescription":43,"studyPopulation":34,"armGroups":44,"interventions":57,"overallOfficials":67,"centralContacts":72,"locations":34,"responsibleParty":78,"collaborators":34,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":34,"eligibilityCriteria":88,"healthyVolunteers":84,"sex":89,"minAge":90,"maxAge":34,"enrollmentInfo":91,"targetDuration":34,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":106,"whyStopped":34,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":34},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":34},[9],{"measure":10,"description":11,"timeFrame":12},"Number of participants with complete clinical clearance","Number of participants with complete clinical clearance defined as complete disappearance of plantar wart and restoration of normal skin markings","At 12 weeks",[14,18,22,25,28,31],{"measure":15,"description":16,"timeFrame":17},"Time to complete clearance","Time in weeks from treatment start to complete clinical clearance","Up to 12 weeks",{"measure":19,"description":20,"timeFrame":21},"Change in wart surface area","Change in wart surface area in square millimeters measured in two perpendicular diameters using digital caliper from baseline","From baseline to 12 weeks",{"measure":23,"description":24,"timeFrame":17},"Treatment-related pain score","Pain score assessed using 0 to 10 Visual Analogue Scale with 0 indicating no pain and 10 indicating worst pain with higher scores indicating worse pain",{"measure":26,"description":27,"timeFrame":17},"Number of participants with local adverse effects","Number of participants who develop local adverse effects including blistering hyperpigmentation scarring or secondary infection",{"measure":29,"description":30,"timeFrame":12},"Patient satisfaction score","Patient satisfaction assessed using 0 to 10 satisfaction scale with higher scores indicating greater satisfaction",{"measure":32,"description":33,"timeFrame":17},"Number of participants with recurrence","Number of participants with recurrence of plantar warts after initial complete clearance",null,{"allocation":36,"interventionModel":37,"interventionModelDescription":34,"primaryPurpose":38,"observationalModel":34,"timePerspective":34,"maskingInfo":39},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":40,"maskingDescription":34,"whoMasked":41},"SINGLE",[42],"OUTCOMES_ASSESSOR","Plantar warts are common benign lesions caused by human papillomavirus on weight-bearing areas causing pain and functional impairment. This is a randomized parallel assignment study conducted at the Outpatient Dermatology Clinic Assiut University Hospital. Eligible patients with clinically diagnosed plantar warts will be randomized in 1 to 1 ratio to topical hydrogen peroxide 40 percent applied once weekly by physician or topical salicylic acid 40 percent self-applied once daily. Treatment duration 12 weeks with assessments every 2 weeks including measurement size photographs clearance status adverse effects compliance and satisfaction.",[45,51],{"label":46,"type":47,"description":48,"interventionNames":49},"Topical Hydrogen Peroxide 40%","EXPERIMENTAL","Stabilized topical hydrogen peroxide 40 percent w\u002Fw applied directly onto wart surface using single-use wooden-tipped applicator avoiding surrounding skin once weekly by physician for 12 weeks or until complete clearance after soaking foot 5 to 10 minutes and gentle debridement",[50],"Drug: Hydrogen Peroxide 40%",{"label":52,"type":53,"description":54,"interventionNames":55},"Topical Salicylic Acid 40%","ACTIVE_COMPARATOR","Commercially available salicylic acid 40 percent w\u002Fw as paint or plaster self-applied once daily onto wart surface with protection of surrounding skin with petrolatum for 12 weeks after soaking and gentle paring",[56],"Drug: Salicylic Acid 40%",[58,63],{"type":59,"name":60,"description":61,"armGroupLabels":62,"otherNames":34},"DRUG","Hydrogen Peroxide 40%","Topical hydrogen peroxide 40 percent w\u002Fw solution in opaque light-protected applicator bottle applied once weekly for up to 12 weeks",[46],{"type":59,"name":64,"description":65,"armGroupLabels":66,"otherNames":34},"Salicylic Acid 40%","Topical salicylic acid 40 percent w\u002Fw preparation applied once daily for up to 12 weeks",[52],[68],{"name":69,"affiliation":70,"role":71},"Saher A Moez, prof","Dermatology Department, Assiut University Hospitals","STUDY_CHAIR",[73],{"name":74,"role":75,"phone":76,"phoneExt":34,"email":77},"Mohamed A Abdel rady, Resident","CONTACT","01024907721","mohamedradybalela199769@gmail.com",{"type":79,"investigatorFullName":80,"investigatorTitle":81,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"PRINCIPAL_INVESTIGATOR","Mohamed Ahmed Abdelrady Mahmoud","Resident Physician, Department of Dermatology, Venereology and Andrology","100656937","phase-3-hydrogen-peroxide-40-versus-salicylic-acid-40-for-plantar-warts-100656937",false,"NCT07830979","Hydrogen Peroxide 40% Versus Salicylic Acid 40% for Plantar Warts","Topical Hydrogen Peroxide 40% Versus Salicylic Acid 40% in the Treatment of Plantar Warts: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age greater than or equal to 12 years of both sexes\n* Clinically diagnosed plantar wart or warts\n* Wart duration at least 2 weeks prior to enrollment\n* Willing and able to give written informed consent or parental consent for minors\n* Able to attend follow-up visits and comply with home-application protocol\n\nExclusion Criteria:\n\n* Pregnant or lactating women\n* Immunocompromised patients including HIV infection organ transplant recipients or on immunosuppressive therapy\n* Diabetic patients with peripheral neuropathy or peripheral arterial disease\n* Known hypersensitivity to hydrogen peroxide or salicylic acid\n* Received any topical or systemic wart treatment within preceding 4 weeks\n* Clinically atypical lesions raising suspicion of malignancy\n* Active local skin infection or open wound at treatment site\n* Unable or unwilling to complete follow-up schedule","ALL","12 Years",{"count":92,"type":93},70,"ESTIMATED","INTERVENTIONAL",[96],"PHASE3","This randomized controlled trial aims to compare the efficacy and safety of topical hydrogen peroxide 40 percent versus topical salicylic acid 40 percent in the treatment of plantar warts.",[99],"Plantar Wart",[101,102,103,104,105],"Hydrogen peroxide","Salicylic acid","Plantar warts","Topical treatment","HPV","NOT_YET_RECRUITING","2026-09-18",{"date":109,"type":110},"2026-09-22","ACTUAL",{"date":112,"type":93},"2026-09-20",{"date":114,"type":93},"2028-02-20",{"name":5,"class":6}]