[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646255":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":35,"centralContacts":40,"locations":45,"responsibleParty":51,"collaborators":55,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":59,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":45,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":78,"overallStatus":83,"whyStopped":45,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":45},{"fullName":5,"class":6},"Nanjing University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Mild Endometrial Stimulation With Intrauterine G-CSF Infusion","EXPERIMENTAL","Participants in this arm will undergo mild endometrial stimulation followed by intrauterine infusion of G-CSF 300 μg during the endometrial preparation cycle for frozen-thawed embryo transfer.",[13],"Biological: Granulocyte Colony-Stimulating Factor(G-CSF)",{"label":15,"type":16,"description":17,"interventionNames":18},"Mild Endometrial Stimulation With Intrauterine Normal Saline Infusion","PLACEBO_COMPARATOR","Participants in this arm will undergo the same mild endometrial stimulation procedure followed by intrauterine infusion of an equal volume of normal saline during the endometrial preparation cycle for frozen-thawed embryo transfer.",[19],"Drug: Normal Saline",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BIOLOGICAL","Granulocyte Colony-Stimulating Factor(G-CSF)","Participants in the experimental arm will receive a single intrauterine infusion of G-CSF 300 μg after mild endometrial stimulation during the endometrial preparation cycle for frozen-thawed embryo transfer.",[9],[27],"Recombinant Human Granulocyte Colony-Stimulating Factor",{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"DRUG","Normal Saline","Participants in the control arm will receive a single intrauterine infusion of an equal volume of normal saline after the same mild endometrial stimulation procedure during the endometrial preparation cycle for frozen-thawed embryo transfer.",[15],[34],"Saline",[36],{"name":37,"affiliation":38,"role":39},"Yue Jiang","Nanjing Drum Tower Hospital: Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital","PRINCIPAL_INVESTIGATOR",[41,47],{"name":42,"role":43,"phone":44,"phoneExt":45,"email":46},"Yue Jiang, PhD","CONTACT","+8618262637731",null,"jiangyue85@163.com",{"name":48,"role":43,"phone":49,"phoneExt":45,"email":50},"Hui Zhang, PhD","18262637731","hellozhanghui@sina.cn",{"type":39,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":54,"oldNameTitle":45,"oldOrganization":45},"Li-jun Ding","Research Professor","The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School",[56],{"name":54,"class":6},"100646255","phase-3-intrauterine-g-csf-infusion-for-thin-endometrium-100646255",false,"NCT07692672","Intrauterine G-CSF Infusion for Thin Endometrium","A Single-Center Randomized Controlled Trial of Intrauterine G-CSF Infusion for Improving Pregnancy Outcomes in Patients With Thin Endometrium","GIFT","Inclusion Criteria:\n\n* Female patients aged 18 to \\\u003C40 years.\n* Patients with normal ovarian function.\n* History of endometrial thickness ≤7 mm in at least one previous endometrial preparation cycle.\n* At least two good-quality embryos remaining.\n* Fewer than 3 previous embryo transfer cycles.\n* Willing and able to provide written informed consent.\n\nExclusion Criteria:\n\n* Uterine diseases or conditions that may affect the uterine cavity, including intramural uterine fibroids affecting the uterine cavity, severe adenomyosis, endometriosis, uterine malformation, endometrial tuberculosis, or severe untreated intrauterine adhesions.\n* Endometrial lesions, history of pelvic tumors, or previous radiotherapy or chemotherapy.\n* Known allergy to G-CSF.\n* Current participation in another clinical study.","FEMALE","18 Years","39 Years",{"count":69,"type":70},620,"ESTIMATED","INTERVENTIONAL",[73],"PHASE3","Thin endometrium is a condition in which the lining of the uterus is too thin during preparation for embryo transfer. This may reduce the chance of pregnancy and live birth in patients undergoing frozen-thawed embryo transfer.\n\nThis study will evaluate whether intrauterine infusion of granulocyte colony-stimulating factor, also called G-CSF, can improve pregnancy outcomes in patients with thin endometrium. Participants will be randomly assigned to one of two groups. The experimental group will receive mild endometrial stimulation followed by intrauterine infusion of G-CSF 300 μg. The control group will receive the same mild endometrial stimulation followed by intrauterine infusion of normal saline. Both groups will then continue standard endometrial preparation for frozen-thawed embryo transfer.\n\nThe main outcome of the study is the live birth rate. The study will also assess endometrial thickness, endometrial blood flow, clinical pregnancy rate, miscarriage rate, and safety outcomes, including adverse events, pregnancy complications, fetal malformations, and neonatal birth defects. Participants will be followed from enrollment through embryo transfer, pregnancy assessment, and delivery.\n\nThis is a single-center, prospective, randomized controlled trial conducted at Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School. The planned sample size is 620 participants.",[76,77],"Thin Endometrium","Female Infertility",[76,79,80,81,82],"G-CSF","Intrauterine Infusion","Frozen-Thawed Embryo Transfer","Live Birth Rate","NOT_YET_RECRUITING","2026-07-08",{"date":86,"type":87},"2026-07-09","ACTUAL",{"date":89,"type":70},"2026-10",{"date":91,"type":70},"2029-08",{"name":5,"class":6}]