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dexmedetomidine (1 μg\u002Fkg over 40 minutes, a maximal dose of 80 μg) and a sublingual placebo (inert film) will be administered nightly for the first three nights while the patient is in the intensive care unit.",[13,14],"Drug: Intravenous Dexmedetomidine","Drug: Sublingual Placebo",{"label":16,"type":10,"description":17,"interventionNames":18},"Sublingual Dexmedetomidine","After admission to the ICU and discontinuation of mechanical ventilation, sublingual dexmedetomidine (120 μg) and an intravenous placebo (0.9% saline over 40 minutes) will be administered nightly for the first three nights while the patient is in the intensive care unit.",[19,20],"Drug: Sublingual Dexmedetomidine","Drug: Intravenous Placebo",{"label":22,"type":23,"description":24,"interventionNames":25},"Placebo","PLACEBO_COMPARATOR","After admission to the ICU and discontinuation of mechanical ventilation, an intravenous placebo (0.9% saline over 40 minutes) and a sublingual placebo (inert film) will be administered nightly for the first three nights while the patient is in the intensive care unit.",[20,14],[27,33,38,43],{"type":28,"name":9,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","Intravenous dexmedetomidine (1 μg\u002Fkg over 40 minutes, a maximal dose of 80 μg)",[9],[32],"Intravenous Precedex",{"type":28,"name":16,"description":34,"armGroupLabels":35,"otherNames":36},"Sublingual dexmedetomidine (120 μg)",[16],[37],"Sublingual Precedex",{"type":28,"name":39,"description":40,"armGroupLabels":41,"otherNames":42},"Intravenous Placebo","Intravenous placebo of 0.9% saline administered over 40 minutes",[22,16],[22],{"type":28,"name":44,"description":45,"armGroupLabels":46,"otherNames":47},"Sublingual Placebo","Inert sublingual film",[9,22],[22],[49],{"name":50,"affiliation":5,"role":51},"Oluwaseun Johnson-Akeju, 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Francisco","94117",{"type":72,"coordinates":85},[86,87],-122.41942,37.77493,{"lat":87,"lon":86},[90],{"name":91,"role":54,"phone":56,"phoneExt":56,"email":56},"Matthieu Legrand, MD",{"facility":93,"status":94,"city":95,"state":96,"zip":97,"country":69,"countryCode":70,"cosmosGeoPoint":98,"geoPoint":102,"contacts":103},"Northwestern University Feinberg School of Medicine","RECRUITING","Chicago","Illinois","60611",{"type":72,"coordinates":99},[100,101],-87.65005,41.85003,{"lat":101,"lon":100},[104],{"name":105,"role":54,"phone":56,"phoneExt":56,"email":56},"Charles Hogue, MD",{"facility":107,"status":94,"city":108,"state":109,"zip":110,"country":69,"countryCode":70,"cosmosGeoPoint":111,"geoPoint":115,"contacts":116},"University of Iowa Carver College of Medicine","Iowa City","Iowa","522421320",{"type":72,"coordinates":112},[113,114],-91.53017,41.66113,{"lat":114,"lon":113},[117],{"name":118,"role":54,"phone":56,"phoneExt":56,"email":56},"Andrew Feider, 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Center","02215",{"type":72,"coordinates":148},[138,139],{"lat":139,"lon":138},[151],{"name":152,"role":54,"phone":56,"phoneExt":56,"email":56},"Shahzad Shaefi, MD",{"facility":154,"status":94,"city":133,"state":134,"zip":146,"country":69,"countryCode":70,"cosmosGeoPoint":155,"geoPoint":157,"contacts":158},"Brigham and Women's Hospital",{"type":72,"coordinates":156},[138,139],{"lat":139,"lon":138},[159],{"name":50,"role":54,"phone":56,"phoneExt":56,"email":56},{"facility":161,"status":65,"city":162,"state":163,"zip":164,"country":69,"countryCode":70,"cosmosGeoPoint":165,"geoPoint":169,"contacts":170},"Washington University School of Medicine","St Louis","Missouri","63110",{"type":72,"coordinates":166},[167,168],-90.19789,38.62727,{"lat":168,"lon":167},[171],{"name":172,"role":54,"phone":56,"phoneExt":56,"email":56},"Ben Palanca, MD",{"facility":174,"status":94,"city":175,"state":176,"zip":177,"country":69,"countryCode":70,"cosmosGeoPoint":178,"geoPoint":182,"contacts":183},"University of Nebraska Medical Center","Omaha","Nebraska","68198",{"type":72,"coordinates":179},[180,181],-95.94043,41.25626,{"lat":181,"lon":180},[184],{"name":185,"role":54,"phone":56,"phoneExt":56,"email":56},"Shaun Thompson, MD",{"facility":187,"status":94,"city":188,"state":188,"zip":189,"country":69,"countryCode":70,"cosmosGeoPoint":190,"geoPoint":194,"contacts":195},"Columbia University Medical Center","New York","10032",{"type":72,"coordinates":191},[192,193],-74.00597,40.71427,{"lat":193,"lon":192},[196],{"name":197,"role":54,"phone":56,"phoneExt":56,"email":56},"Vivek Moitra, MD",{"facility":199,"status":65,"city":200,"state":188,"zip":201,"country":69,"countryCode":70,"cosmosGeoPoint":202,"geoPoint":206,"contacts":207},"Montefiore Medical Center","The Bronx","10467",{"type":72,"coordinates":203},[204,205],-73.86641,40.84985,{"lat":205,"lon":204},[208],{"name":209,"role":54,"phone":56,"phoneExt":56,"email":56},"Matthias Eikermann, 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in English\n* Patients experiencing circumstances for which long-term follow-up might be difficult (e.g., homelessness, active psychotic disorder, or substance abuse)\n* Co-enrollment in other interventional studies that, in the opinion of the site investigator and\u002For PI, might interfere with study participation, collection, or interpretation of the study data","ALL","60 Years",{"count":249,"type":250},1800,"ESTIMATED","INTERVENTIONAL",[253],"PHASE3","This is a pragmatic phase III, randomized, blinded, double placebo-controlled, three-arm trial of elderly patients following cardiac surgery to assess the relationship between nighttime intravenous (IV) and sublingual dexmedetomidine on postoperative delirium and functional outcomes after surgery.",[256],"Delirium","2026-07-01",{"date":259,"type":260},"2026-07-06","ACTUAL",{"date":262,"type":260},"2025-01-06",{"date":264,"type":250},"2029-03-31",{"name":5,"class":6},14]