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Oblast","18009","Ukraine","UA",{"type":121,"coordinates":1214},[1215,1216],32.05738,49.44452,{"lat":1216,"lon":1215},[1219],{"name":113,"role":99,"phone":1220,"phoneExt":48,"email":48},"+380472370123",{"facility":1222,"status":105,"city":1223,"state":1224,"zip":1225,"country":1211,"countryCode":1212,"cosmosGeoPoint":1226,"geoPoint":1230,"contacts":1231},"Regional Municipal Non-profit Enterprise \"Bukovinian Clinical Oncology Center\" ( Site 1909)","Chernivtsi","Chernivetska Oblast","58013",{"type":121,"coordinates":1227},[1228,1229],25.93241,48.29045,{"lat":1229,"lon":1228},[1232],{"name":113,"role":99,"phone":1233,"phoneExt":48,"email":48},"+380505144910",{"facility":1235,"status":105,"city":1236,"state":1237,"zip":1238,"country":1211,"countryCode":1212,"cosmosGeoPoint":1239,"geoPoint":1243,"contacts":1244},"Medical Center \"Mriya Med-Service\" ( Site 1911)","Kryvyi Rih","Dnipropetrovsk Oblast","50000",{"type":121,"coordinates":1240},[1241,1242],33.39404,47.90572,{"lat":1242,"lon":1241},[1245],{"name":113,"role":99,"phone":1246,"phoneExt":48,"email":48},"+380677490687",{"facility":1248,"status":105,"city":1249,"state":1250,"zip":1251,"country":1211,"countryCode":1212,"cosmosGeoPoint":1252,"geoPoint":1256,"contacts":1257},"Communal Non-Commercial Enterprise Prykarpatski Clinical Oncological Center of Ivano-Frankivsk Regio ( Site 1900)","Ivano-Frankivsk","Ivano-Frankivsk Oblast","76018",{"type":121,"coordinates":1253},[1254,1255],24.71248,48.92312,{"lat":1255,"lon":1254},[1258],{"name":113,"role":99,"phone":1259,"phoneExt":48,"email":48},"+380342507353",{"facility":1261,"status":105,"city":1262,"state":1263,"zip":1264,"country":1211,"countryCode":1212,"cosmosGeoPoint":1265,"geoPoint":1269,"contacts":1270},"Private Enterprise Private Manufacturing Company Acinus-Medical and Diagnostic Centre ( Site 1916)","Kropyvnytskyi","Kirovohrad 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Oblast","65025",{"type":121,"coordinates":1310},[1311,1312],30.74383,46.48572,{"lat":1312,"lon":1311},[1315],{"name":113,"role":99,"phone":1316,"phoneExt":48,"email":48},"+380931860876",{"facility":1318,"status":105,"city":1319,"state":1320,"zip":1321,"country":1211,"countryCode":1212,"cosmosGeoPoint":1322,"geoPoint":1326,"contacts":1327},"ME \"Rivne Regional Antitumor Center\" Rivne Regional Council ( Site 1912)","Rivne","Rivne Oblast","33010",{"type":121,"coordinates":1323},[1324,1325],26.23695,50.62036,{"lat":1325,"lon":1324},[1328],{"name":113,"role":99,"phone":1329,"phoneExt":48,"email":48},"+380971921000",{"facility":1331,"status":105,"city":1332,"state":1333,"zip":1334,"country":1211,"countryCode":1212,"cosmosGeoPoint":1335,"geoPoint":1339,"contacts":1340},"Communal Noncommercial Enterprise \"Podillia Regional Oncology Center Of Vinnytsia Regional Council\" ( Site 1903)","Vinnytsia","Vinnytsia Oblast","21029",{"type":121,"coordinates":1336},[1337,1338],28.46871,49.2322,{"lat":1338,"lon":1337},[1341],{"name":113,"role":99,"phone":1342,"phoneExt":48,"email":48},"+380988936318",{"facility":1344,"status":105,"city":1345,"state":1346,"zip":1347,"country":1211,"countryCode":1212,"cosmosGeoPoint":1348,"geoPoint":1352,"contacts":1353},"Municipal Enterprise \"Volyn Regional Clinical Hospital\" of Volyn Regional Council ( Site 1914)","Lutsk","Volyn Oblast","43018",{"type":121,"coordinates":1349},[1350,1351],25.35024,50.75784,{"lat":1351,"lon":1350},[1354],{"name":113,"role":99,"phone":1355,"phoneExt":48,"email":48},"+380332773100",{"facility":1357,"status":105,"city":1358,"state":48,"zip":1359,"country":1211,"countryCode":1212,"cosmosGeoPoint":1360,"geoPoint":1364,"contacts":1365},"Medical Center \"Universal Clinic \"Oberig\" of Limited Liability Company \"Kapytal\" ( Site 1915)","Kyiv","03057",{"type":121,"coordinates":1361},[1362,1363],30.5238,50.45466,{"lat":1363,"lon":1362},[1366],{"name":113,"role":99,"phone":1367,"phoneExt":48,"email":48},"+380669472333",{"facility":1369,"status":105,"city":1358,"state":48,"zip":1370,"country":1211,"countryCode":1212,"cosmosGeoPoint":1371,"geoPoint":1373,"contacts":1374},"Kyiv City Clinical Oncology Center ( Site 1918)","03115",{"type":121,"coordinates":1372},[1362,1363],{"lat":1363,"lon":1362},[1375],{"name":113,"role":99,"phone":1376,"phoneExt":48,"email":48},"+380503818536",{"facility":1378,"status":105,"city":1358,"state":48,"zip":1379,"country":1211,"countryCode":1212,"cosmosGeoPoint":1380,"geoPoint":1382,"contacts":1383},"Shalimov Institute of Surgery and Transplantation ( Site 1907)","03126",{"type":121,"coordinates":1381},[1362,1363],{"lat":1363,"lon":1362},[1384],{"name":113,"role":99,"phone":1385,"phoneExt":48,"email":48},"+380444081800",{"facility":1387,"status":105,"city":1388,"state":1389,"zip":1390,"country":1391,"countryCode":1392,"cosmosGeoPoint":1393,"geoPoint":1397,"contacts":1398},"Imperial College Healthcare NHS Trust, Charing Cross Hospital ( Site 2012)","London","London, City of","W6 8RF","United Kingdom","UK",{"type":121,"coordinates":1394},[1395,1396],-0.12574,51.50853,{"lat":1396,"lon":1395},[1399],{"name":113,"role":99,"phone":1400,"phoneExt":48,"email":48},"+4402033111234",{"facility":1402,"status":105,"city":1403,"state":48,"zip":1404,"country":1391,"countryCode":1392,"cosmosGeoPoint":1405,"geoPoint":1409,"contacts":1410},"Queen Alexandra Hospital ( Site 2011)","Portsmouth","PO6 3LY",{"type":121,"coordinates":1406},[1407,1408],-1.09125,50.79899,{"lat":1408,"lon":1407},[1411],{"name":113,"role":99,"phone":1412,"phoneExt":48,"email":48},"+4402392286000",{"type":1414,"investigatorFullName":48,"investigatorTitle":48,"investigatorAffiliation":48,"oldNameTitle":48,"oldOrganization":48},"SPONSOR","100626145","phase-3-mk-3475acalderasib-mk-1084-in-completely-resected-stage-iia-iiib-n2-kras-g12cm-nsclc-mk-1084-013-100626145",false,"NCT07431827","MK-3475A±Calderasib (MK-1084) in Completely Resected Stage IIA-IIIB (N2) KRAS G12Cm NSCLC (MK-1084-013)","A Phase 3, Randomized, Double-blind Study of Adjuvant MK-1084 Plus Subcutaneous Pembrolizumab and Berahyaluronidase Alfa (MK-3475A) Versus Adjuvant Placebo Plus MK-3475A in Participants With Completely Resected Stage IIA-IIIB (N2), KRAS G12C-mutant Non-small Cell Lung Cancer Following Receipt of Either Neoadjuvant Pembrolizumab Plus Chemotherapy or Adjuvant Chemotherapy (KANDLELIT-013)","KANDLELIT-013","Inclusion Criteria:\n\n* Has a histological\u002Fcytological diagnosis of non-small cell lung cancer (NSCLC) with predominantly nonsquamous histology and meets one of the following criteria:\n\n  * Has newly diagnosed, treatment-naïve, resectable, clinical Stage IIA-IIIB (N2) NSCLC\n  * Has completely resected, pathological Stage IIA-IIIB (N2) NSCLC, including those previously treated outside the study with neoadjuvant platinum-doublet chemotherapy plus pembrolizumab or MK-3475A, or those who received adjuvant platinum-doublet chemotherapy.\n* Tumor tissue shows the presence of Kirsten rat sarcoma viral oncogene homolog G12C (KRAS G12C) mutation\n* No more than 12 weeks have elapsed between either the surgery following neoadjuvant treatment or last dose of adjuvant platinum-based chemotherapy and the first dose of investigational adjuvant study intervention.\n* Has no evidence of disease based on postsurgical radiological assessment as documented by contrast-enhanced chest\u002Fabdomen computed tomography (or magnetic resonance imaging) within 28 days before randomization\n* Has an Eastern Cooperative Oncology Group performance status of 0 or 1 within 10 days before the first dose of the study intervention\n* Human immunodeficiency virus-infected participants must have well controlled HIV on antiretroviral therapy\n* Participants who are Hepatitis B surface antigen positive are eligible if they have received hepatitis B virus (HBV) antiviral therapy and have undetectable HBV viral load\n* Participants with history of hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable\n\nExclusion Criteria:\n\n* Has a diagnosis of any 1 of the following tumor types\u002Flocations: small cell lung cancer or, for mixed tumors, presence of small cell elements, neuroendocrine tumor with large cell components, sarcomatoid carcinoma, or NSCLC involving the superior sulcus\n* HIV-infected participants with a history of Kaposi's sarcoma and\u002For Multicentric Castleman's Disease\n* Has active inflammatory bowel disease requiring immunosuppressive medication or previous clear history of inflammatory bowel disease (eg, Crohn's disease, ulcerative colitis, chronic diarrhea)\n* Has uncontrolled, significant cardiovascular disease or cerebrovascular disease within the 6 months preceding study intervention\n* Is unable to swallow orally administered medication, or has a gastrointestinal disorder affecting absorption (e.g. gastrectomy, partial bowel obstruction, or malabsorption)\n* Has known additional malignancy that is progressing or has required active treatment within the past 3 years\n* Has an active autoimmune disease that has required systemic treatment in the past 2 years except replacement therapy\n* Has a history of (noninfectious) pneumonitis\u002Finterstitial lung disease that required steroids or has current pneumonitis\u002Finterstitial lung disease\n* Has active infection requiring systemic therapy\n* Has not adequately recovered from major surgery or has ongoing surgical complications","ALL","18 Years",{"count":1426,"type":1427},400,"ESTIMATED","INTERVENTIONAL",[1430],"PHASE3","This is a phase 3, randomized, double-blind study of adjuvant calderasib plus subcutaneous pembrolizumab and berahyaluronidase alfa (MK-3475A) versus adjuvant placebo plus MK-3475a in participants with completely resected stage IIA-IIIB (N2), KRAS G12C-mutant non-small cell lung cancer following receipt of either neoadjuvant pembrolizumab plus chemotherapy or adjuvant chemotherapy. The primary goal of the study is to compare adjuvant calderasib plus MK-3475A to adjuvant placebo plus MK-3475A with respect to disease-free survival (DFS) as assessed by the investigator.",[1433],"Non-small Cell Lung Cancer","2026-10-06",{"date":1436,"type":1437},"2026-10-07","ACTUAL",{"date":1439,"type":1437},"2026-03-18",{"date":1441,"type":1427},"2039-10-26",{"name":5,"class":6},112]