[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650082":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":22,"locations":18,"responsibleParty":28,"collaborators":18,"id":31,"slug":32,"hasResults":33,"nctId":34,"briefTitle":35,"officialTitle":36,"acronym":18,"eligibilityCriteria":37,"healthyVolunteers":33,"sex":38,"minAge":39,"maxAge":18,"enrollmentInfo":40,"targetDuration":18,"studyType":43,"phases":44,"briefSummary":46,"conditions":47,"keywords":49,"overallStatus":51,"whyStopped":18,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":18},{"fullName":5,"class":6},"University of Toronto","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Mindfulness-Based Cognitive Therapy","EXPERIMENTAL","Online group Mindfulness-Based Cognitive Therapy delivered live online in weekly sessions for 8 weeks",[13],"Other: Mindfulness-Based Cognitive Therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Waitlist control","NO_INTERVENTION","Waitlist control arm - participants receive no intervention initially but receive MBCT following data collection",null,[20],{"type":6,"name":9,"description":11,"armGroupLabels":21,"otherNames":18},[9],[23],{"name":24,"role":25,"phone":26,"phoneExt":18,"email":27},"Robert Simpson","CONTACT","416-978-8383","rab.simpson@utoronto.ca",{"type":29,"investigatorFullName":24,"investigatorTitle":30,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"SPONSOR_INVESTIGATOR","Associate Professor","100650082","phase-3-online-mindfulness-based-cognitive-therapy-for-people-with-multiple-sclerosis-with-mild-moderate-depression-100650082",false,"NCT07742579","Online Mindfulness-Based Cognitive Therapy for People With Multiple Sclerosis With Mild-Moderate Depression","Online Mindfulness-Based Cognitive Therapy for People With Multiple Sclerosis With Mild-Moderate Depression: A Hybrid Effectiveness-Implementation Study","Inclusion criteria will include:\n\n* Age \\>\u002F=18\n* Neurologist confirmed MS diagnosis (McDonald criteria)\n* Able to understand spoken and written English\n* A score of 14-28 on the Beck Depression Inventory-II signifying mild-moderate depression\n* Registered with a primary care provider (family physician or neurologist)\n* Residing in Canada\n\nExclusion criteria will include:\n\n* Potentially life-threatening comorbidities (suicidal ideation (i.e., score of 2 or 3 on the BDI-Fast Screen suicidal ideation question), history of psychosis, terminal\u002Flife threatening inter-current illness), or those such conditions expected to significantly limit participation and adherence (pregnancy, cognitive impairment i.e. score \\\u003C26 on the Montreal Cognitive Assessment - MoCA)\n* Receipt of MBCT in the past 2 years (completed at least 4\u002F8 sessions).","ALL","18 Years",{"count":41,"type":42},152,"ESTIMATED","INTERVENTIONAL",[45],"PHASE3","This study will use a waiting list randomized controlled trial design with a mixed-methods research approach, including both quantitative and qualitative methods. Randomization helps minimize research bias and controls for participant and contextual factors that might otherwise make interpretation of results challenging. We will recruit 152 people with multiple sclerosis (PwMS) with any type of MS, who also have mild-moderate depression, aged 18 or greater, and able to understand spoken and written English.\n\nFor the quantitative part, we will examine how much change in depression there is following mindfulness-based cognitive therapy (MBCT), as well as whether participants attend the course and complete study measures or not, and how much participants complete MBCT home practices. We will also examine how much change there is in fatigue, sleep pain, quality of life, and anxiety.\n\nFor the qualitative part of the study, we will use semi-structured interviews to explore participant experiences of online MBCT, how people used online MBCT, what worked, what didn't and why, how online MBCT impacted self-management of depression, and suggestions for improving the course to make it more relevant for PwMS with depression.",[48],"Multiple Sclerosis",[50,9],"mindfulness","NOT_YET_RECRUITING","2026-07-28",{"date":54,"type":55},"2026-08-03","ACTUAL",{"date":57,"type":42},"2026-08",{"date":59,"type":42},"2028-12",{"name":24,"class":6}]