[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649396":3},{"organization":4,"armGroups":7,"interventions":42,"overallOfficials":65,"centralContacts":72,"locations":77,"responsibleParty":109,"collaborators":112,"id":115,"slug":116,"hasResults":117,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":121,"eligibilityCriteria":122,"healthyVolunteers":117,"sex":123,"minAge":124,"maxAge":48,"enrollmentInfo":125,"targetDuration":48,"studyType":128,"phases":129,"briefSummary":131,"conditions":132,"keywords":135,"overallStatus":146,"whyStopped":48,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":156},{"fullName":5,"class":6},"Prince of Wales Hospital, Shatin, Hong Kong","OTHER",[8,15,20,25,30,34,38],{"label":9,"type":10,"description":11,"interventionNames":12},"First stage: Buffered","EXPERIMENTAL","One eyelid: lignocaine buffered with sodium bicarbonate; the other eyelid: unmodified solution of lignocaine",[13,14],"Drug: Sodium Bicarbonate (NaHCO3)","Drug: Lignocaine 2% concentration solution",{"label":16,"type":10,"description":17,"interventionNames":18},"First stage: Warmed","One eyelid: lignocaine warmed to body temperature; the other eyelid: unmodified solution of lignocaine at room temperature",[19,14],"Drug: Warmed lignocaine",{"label":21,"type":10,"description":22,"interventionNames":23},"First stage: Hyaluronidase","One eyelid: lignocaine with hyaluronidase added; the other eyelid: unmodified solution of lignocaine",[24,14],"Drug: Hyaluronidase Injection",{"label":26,"type":10,"description":27,"interventionNames":28},"First stage: Tranexamic acid","One eyelid: lignocaine with tranexamic acid added; the other eyelid: unmodified solution of lignocaine",[29,14],"Drug: Tranexamic Acid (TXA)",{"label":31,"type":10,"description":32,"interventionNames":33},"Second stage: Most effective modification A versus B","One eyelid: modification A; the other eyelid: modification B",[13,19,24,29,14],{"label":35,"type":10,"description":36,"interventionNames":37},"Second stage: Most effective modification A+B versus A","One eyelid: modification A+B; the other eyelid: modification A",[13,19,24,29,14],{"label":39,"type":10,"description":40,"interventionNames":41},"Second stage: Most effective modification A+B versus B","One eyelid: modification A+B; the other eyelid: modification B",[13,19,24,29,14],[43,49,53,57,61],{"type":44,"name":45,"description":46,"armGroupLabels":47,"otherNames":48},"DRUG","Sodium Bicarbonate (NaHCO3)","Lignocaine buffered with sodium bicarbonate",[9,31,35,39],null,{"type":44,"name":50,"description":51,"armGroupLabels":52,"otherNames":48},"Warmed lignocaine","Lignocaine warmed to body temperature",[16,31,35,39],{"type":44,"name":54,"description":55,"armGroupLabels":56,"otherNames":48},"Hyaluronidase Injection","Lignocaine with hyaluronidase added",[21,31,35,39],{"type":44,"name":58,"description":59,"armGroupLabels":60,"otherNames":48},"Tranexamic Acid (TXA)","Lignocaine with tranexamic acid added",[26,31,35,39],{"type":44,"name":62,"description":63,"armGroupLabels":64,"otherNames":48},"Lignocaine 2% concentration solution","2% lignocaine with 1:200,000 adrenaline",[9,21,26,16,31,35,39],[66,69],{"name":67,"affiliation":5,"role":68},"Kelvin Kam Lung Chong","STUDY_CHAIR",{"name":70,"affiliation":5,"role":71},"Anson Chun Long Wu","PRINCIPAL_INVESTIGATOR",[73],{"name":70,"role":74,"phone":75,"phoneExt":48,"email":76},"CONTACT","+852 35052878","wcl589@ha.org.hk",[78,91,101],{"facility":79,"status":48,"city":80,"state":48,"zip":48,"country":80,"countryCode":81,"cosmosGeoPoint":82,"geoPoint":87,"contacts":88},"Alice Ho Miu Ling Nethersole Hospital","Hong Kong","HK",{"type":83,"coordinates":84},"Point",[85,86],114.17469,22.27832,{"lat":86,"lon":85},[89,90],{"name":70,"role":74,"phone":75,"phoneExt":48,"email":76},{"name":70,"role":71,"phone":48,"phoneExt":48,"email":48},{"facility":92,"status":48,"city":80,"state":48,"zip":48,"country":80,"countryCode":81,"cosmosGeoPoint":93,"geoPoint":95,"contacts":96},"CUHK Medical Centre",{"type":83,"coordinates":94},[85,86],{"lat":86,"lon":85},[97,100],{"name":67,"role":74,"phone":98,"phoneExt":48,"email":99},"+852 39435824","chongkamlung@cuhk.edu.hk",{"name":67,"role":71,"phone":48,"phoneExt":48,"email":48},{"facility":102,"status":48,"city":80,"state":48,"zip":48,"country":80,"countryCode":81,"cosmosGeoPoint":103,"geoPoint":105,"contacts":106},"Prince of Wales Hospital",{"type":83,"coordinates":104},[85,86],{"lat":86,"lon":85},[107,108],{"name":70,"role":74,"phone":75,"phoneExt":48,"email":76},{"name":67,"role":71,"phone":48,"phoneExt":48,"email":48},{"type":71,"investigatorFullName":110,"investigatorTitle":111,"investigatorAffiliation":5,"oldNameTitle":48,"oldOrganization":48},"Wu Chun Long","Principal Investigator",[113],{"name":114,"class":6},"Chinese University of Hong Kong","100649396","phase-3-perioperative-haemostasis-procedure-related-pain-after-physiological-or-pharmacological-modifications-of-local-anaesthesia-around-the-eyes-100649396",false,"NCT07734740","Perioperative Haemostasis, Procedure-Related Pain After Physiological or Pharmacological Modifications of Local Anaesthesia Around the Eyes","Perioperative Haemostasis, Procedure-Related Pain After Physiological or Pharmacological Modifications of Local Anaesthesia Around the Eyes (P4LE) - a Double-Masked, Split-Face, Active-Controlled, Pilot Randomised Clinical Trial","P4LE","Inclusion Criteria:\n\n* Patients undergoing bilateral upper eyelid blepharoplasty requiring subcutaneous anaesthesia at Prince of Wales Hospital, Alice Ho Miu Ling Nethersole Hospital and CUHK Medical Centre; and\n* Adult patients aged 18 or above.\n\nExclusion Criteria:\n\n* Patients aged less than 18;\n* Pregnancy;\n* Allergy to local anaesthetic agents;\n* History of previous eyelid surgery; and\n* Patients on antiplatelets or anticoagulants.","ALL","18 Years",{"count":126,"type":127},80,"ESTIMATED","INTERVENTIONAL",[130],"PHASE3","The goal of this clinical trial is to determine whether buffering, warming, or addition of hyaluronidase or tranexamic acid to lignocaine during eyelid injection of local anaesthesia reduce injection pain and procedure-related pain and improve perioperative haemostasis.",[133,134],"Dermatochalasis of Upper Eyelid","Blepharoplasty",[136,134,137,138,139,140,141,142,143,144,145],"Dermatochalasis","Local anaesthesia","Lignocaine","Sodium bicarbonate","Hyaluronidase","Tranexamic acid","Buffered","Warmed","Pain","Haemostasis","NOT_YET_RECRUITING","2026-07-30",{"date":149,"type":150},"2026-08-03","ACTUAL",{"date":152,"type":127},"2026-08",{"date":154,"type":127},"2028-07",{"name":5,"class":6},3]