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eligible for locoregional therapy) or stage C.\n* Child-Pugh Score class A\n* At least one measurable target lesion\n* Participants with active HBV infection must receive antiviral therapy for a minimum of 14 days prior to randomization to show evidence of HBV stabilization or signs of viral response.\n* Participants with active HCV infection must be well controlled. Participants co-infected with HBV and HCV are not eligible.\n* Adequate organ and bone marrow function measured during the screening period.\n* Adequate organ and bone marrow function measured during the screening period\n* Must not have received prior systemic therapy for intermediate, advanced, or metastatic HCC.\n* Disease that is not amenable to curative surgical and\u002For locoregional therapies. For participants who received locoregional therapy for HCC, locoregional therapy must have been completed ≥ 28 days prior to the baseline scan for the current study.\n\nExclusion Criteria:\n\nMedical condition\n\n* Any evidence of uncontrolled intercurrent diseases\n* Active or prior documented autoimmune or inflammatory disorders requiring chronic treatment with steroids or other immunosuppressive treatment\n* History of another primary malignancy\n* Persistent toxicities caused by previous anti-cancer therapy excluding alopecia, not yet improved to Grade ≤ 1 or baseline.\n* Clinically meaningful ascites, pleural effusion, or pericardial effusion requiring non-pharmacologic intervention to maintain symptomatic control within 6 months prior to the first scheduled dose.\n* History of active primary immunodeficiency or active infection\n* History of hepatic encephalopathy\n* Current or recent (within 10 days of first dose of study treatment) use of aspirin (≥ 325 mg\u002Fday) or treatment with dipyridamole, ticlopidine, clopidogrel, and cilostazol\n* Current or recent (within 10 days prior to study treatment start) use of full-dose oral or parenteral anticoagulants or thrombolytic agents for therapeutic (as opposed to prophylactic) purposes is ineligible\n* History of significant bleeding disorders, vasculitis, or a significant bleeding episode from the GI tract within 6 months prior to study randomization.\n* Participants with untreated or incompletely treated varices with bleeding or high-risk (red wale signs or other high-risk factors) for bleeding.\n\nHCC related\n\n* Known fibrolamellar HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC.\n* Central nervous system metastases or spinal cord compression (including asymptomatic and adequately treated disease)\n* Prior treatment with anti-CTLA-4 and\u002For anti-TIGIT.\n* Radiotherapy within 28 days and abdominal\u002F pelvic radiotherapy within 60 days prior to initiation of study treatment, except palliative radiotherapy to bone lesions within 7 days prior to initiation of study treatment","ALL","18 Years",{"count":1807,"type":1808},1220,"ESTIMATED","INTERVENTIONAL",[1811],"PHASE3","This is a Phase III, randomised, open-label, sponsor-blinded, 3-arm, multicentre, global study assessing the efficacy and safety of rilvegostomig in combination with bevacizumab with or without tremelimumab compared to atezolizumab in combination with bevacizumab. 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