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Rutter","paige.rutter@ahn.org",{"name":678,"role":29,"phone":23,"phoneExt":23,"email":23},"Tarun Sharma",{"name":680,"role":91,"phone":23,"phoneExt":23,"email":23},"Sonia Manocha",{"facility":682,"status":43,"city":683,"state":632,"zip":684,"country":47,"countryCode":48,"cosmosGeoPoint":685,"geoPoint":689,"contacts":690},"PA Regional Center for Arthritis and Osteoporosis Research","Wyomissing","19610",{"type":50,"coordinates":686},[687,688],-75.96521,40.32954,{"lat":688,"lon":687},[691,695],{"name":692,"role":33,"phone":693,"phoneExt":23,"email":694},"Dana Cullen","610-374-8133","dcullen@emkeyarthritis.com",{"name":696,"role":29,"phone":23,"phoneExt":23,"email":23},"Gregory Emkey",{"facility":698,"status":43,"city":699,"state":700,"zip":701,"country":47,"countryCode":48,"cosmosGeoPoint":702,"geoPoint":706,"contacts":707},"Cumberland Rhematology","Crossville","Tennessee","38555",{"type":50,"coordinates":703},[704,705],-85.0269,35.94896,{"lat":705,"lon":704},[708,712],{"name":709,"role":33,"phone":710,"phoneExt":23,"email":711},"Sivalingam Kanagasegar, MD","931-459-7720","drs.kanagasegar@aara.care",{"name":713,"role":33,"phone":710,"phoneExt":23,"email":714},"Wendy LaFever, N\u002FA","w.lafever@aara.care",{"facility":716,"status":43,"city":717,"state":700,"zip":718,"country":47,"countryCode":48,"cosmosGeoPoint":719,"geoPoint":723,"contacts":724},"Vanderbilt University","Nashville","37235",{"type":50,"coordinates":720},[721,722],-86.78444,36.16589,{"lat":722,"lon":721},[725,727],{"name":726,"role":33,"phone":23,"phoneExt":23,"email":23},"Kevin W Byram, MD",{"name":728,"role":33,"phone":729,"phoneExt":23,"email":730},"Pam Krueger","615-875-8356","pamela.krueger@vumc.org",{"facility":732,"status":43,"city":733,"state":734,"zip":735,"country":47,"countryCode":48,"cosmosGeoPoint":736,"geoPoint":740,"contacts":741},"Heritage Rheumatology and Arthritis Care","Colleyville","Texas","76034",{"type":50,"coordinates":737},[738,739],-97.15501,32.88096,{"lat":739,"lon":738},[742,746],{"name":743,"role":33,"phone":744,"phoneExt":23,"email":745},"Dhiman Basu, MD","8175900880","drd.basu@aara.care",{"name":747,"role":33,"phone":744,"phoneExt":23,"email":748},"Natalie Pachinger, N\u002FA","n.pachinger@aara.care",{"facility":750,"status":43,"city":751,"state":734,"zip":752,"country":47,"countryCode":48,"cosmosGeoPoint":753,"geoPoint":757,"contacts":758},"Southwest Medical Center","Dallas","75235",{"type":50,"coordinates":754},[755,756],-96.80667,32.78306,{"lat":756,"lon":755},[759,763],{"name":760,"role":33,"phone":761,"phoneExt":23,"email":762},"Safia Shaikh","469-893-1242","sshaikh@swmedicalgroup.com",{"name":764,"role":29,"phone":23,"phoneExt":23,"email":23},"Chrisette Dharma",{"facility":766,"status":43,"city":767,"state":734,"zip":768,"country":47,"countryCode":48,"cosmosGeoPoint":769,"geoPoint":773,"contacts":774},"Texas Arthritis Center, PA","El Paso","77902",{"type":50,"coordinates":770},[771,772],-106.48693,31.75872,{"lat":772,"lon":771},[775,779],{"name":776,"role":33,"phone":777,"phoneExt":23,"email":778},"Sanjay Chabra, MD","915-317-1660","drs.chabra@aara.care",{"name":780,"role":33,"phone":777,"phoneExt":23,"email":781},"Monica Chabra, N\u002FA","m.chabra@aara.cara",{"facility":783,"status":43,"city":784,"state":734,"zip":785,"country":47,"countryCode":48,"cosmosGeoPoint":786,"geoPoint":790,"contacts":791},"American Arthritis and Rheumatology Associates-Tx PLLC","Harlingen","78550",{"type":50,"coordinates":787},[788,789],-97.6961,26.19063,{"lat":789,"lon":788},[792,796],{"name":793,"role":33,"phone":794,"phoneExt":23,"email":795},"Naiara Alvarez, MD","956-422-3122","drn.alvarez@aara.care",{"name":797,"role":33,"phone":794,"phoneExt":23,"email":798},"Heather Margain, N\u002FA","h.margain@aara.care",{"facility":800,"status":43,"city":801,"state":734,"zip":802,"country":47,"countryCode":48,"cosmosGeoPoint":803,"geoPoint":807,"contacts":808},"Baylor University","Houston","77030",{"type":50,"coordinates":804},[805,806],-95.36327,29.76328,{"lat":806,"lon":805},[809,813],{"name":810,"role":33,"phone":811,"phoneExt":23,"email":812},"Kalpana Bhairavarasu","713-798-3390","kalpana.bhairavarasu@bcm.edu",{"name":810,"role":29,"phone":23,"phoneExt":23,"email":23},{"facility":815,"status":43,"city":816,"state":817,"zip":818,"country":47,"countryCode":48,"cosmosGeoPoint":819,"geoPoint":823,"contacts":824},"Northern Virginia Center for Arthritis-Reston","Reston","Virginia","20190",{"type":50,"coordinates":820},[821,822],-77.3411,38.96872,{"lat":822,"lon":821},[825,829],{"name":826,"role":33,"phone":827,"phoneExt":23,"email":828},"Phong Nguyen, MD","703-293-5239","drp.nguyen@aara.care",{"name":830,"role":33,"phone":827,"phoneExt":23,"email":831},"Lynn Kincaid, N\u002FA","l.kincaid@aara.care",{"facility":833,"status":43,"city":834,"state":835,"zip":836,"country":837,"countryCode":838,"cosmosGeoPoint":839,"geoPoint":843,"contacts":844},"Mount Sinai Hospital (Canada)","Toronto","Ontario","M5T 3L9","Canada","CA",{"type":50,"coordinates":840},[841,842],-79.39864,43.70643,{"lat":842,"lon":841},[845,847],{"name":846,"role":33,"phone":23,"phoneExt":23,"email":23},"Bindee Kuriya, MD",{"name":848,"role":33,"phone":849,"phoneExt":850,"email":851},"Shafina Hasmani","416-586-4800","5489","Shafina.hasmani@sinaihealth.ca",{"type":29,"investigatorFullName":853,"investigatorTitle":854,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Jasvinder A Singh","Professor of Medicine",[856],{"name":857,"class":6},"Patient-Centered Outcomes Research Institute","100415658","phase-3-ra-pro-pragmatic-trial-100415658",false,"NCT04692493","RA-PRO PRAGMATIC TRIAL","A Real-World Comparative Effectiveness Trial of Treatment Strategies in Patients With Rheumatoid Arthritis: The RA-PRO Pragmatic Trial (RA-PROPR)","RA-PROPR","Inclusion Criteria:\n\n1. Patients with active, disabling RA (CDAI ≥10 and HAQ ≥0.5) despite the use\u002Fexperience of a TNFi-biologic OR discontinued the medication(s) due to intolerability or toxicity irrespective of treatment duration prior to the first dose of study drug ;\n2. If receiving glucocorticoids (≤10 mg\u002Fday of prednisone of equivalent) or NSAIDs, on stable doses for ≥2 weeks prior to randomization; and\n3. Insurance plan or patient assistance program allows access to at least 1 drug in each of the two treatment strategies, TNFi-biologic vs. tsDMARD.(TNFi-biologic and tsDMARD) will be obtained through insurance plan or a patient assistance program\u002Fplan.\n\nParticipants will be allowed to continue their conventional synthetic DMARD (csDMARD) therapy if they had been using it for ≥ 3 months and on a stable dose for ≥ 4 weeks prior to the first dose of study drug. The following csDMARDs are allowed: methotrexate (MTX), sulfasalazine, hydroxychloroquine, and leflunomide\n\nExclusion Criteria:\n\n1. Prior treatment with more than three biologics, defined as TNFi-biologic or non-TNFi biologic\n2. Prior treatment with targeted synthetic DMARD\n3. Concomitant use of leflunomide, sulfasalazine, cyclosporine, or azathioprine within 2-months before randomization;\n4. History of sensitivity to all 4 non-TNF-biologic or a targeted synthetic DMARD;\n5. Glucocorticoid injection (intravenous, intramuscular, or intraarticular) within 1 month of study entry;\n6. Live vaccine within 90 days of study entry;\n7. Acute or chronic infections with parenteral antibiotics or hospitalization (including tuberculosis, bacterial sepsis; invasive fungal infections (such as histoplasmosis)) within 1 month or oral antibiotics within 2 weeks of study entry;\n8. History of HIV or any opportunistic infection;\n9. New York Heart Association Class III or IV heart failure;\n10. Latent TB for which anti-tubercular treatment has not been started;\n11. Untreated Hepatitis B or C infection;\n12. History of deep venous thrombosis or pulmonary embolism; or\n13. Pregnant or nursing women; or\n14. History of herpes zoster or shingles in the previous 12 months and not subsequently vaccinated with herpes zoster vaccine.","ALL","18 Years",{"count":869,"type":870},924,"ESTIMATED","INTERVENTIONAL",[873],"PHASE3","The 2021 ACR RA treatment guideline, based on widely acknowledged low to moderate quality evidence, recommends switching to a non-tumor necrosis factor (TNFi) biologic (choose among existing medications, currently, rituximab, abatacept, tocilizumab, or sarilumab) or a targeted synthetic DMARD arm (tsDMARD; choose among existing medications, currently, tofacitinib, baricitinib, upadacitinib) in patients with active RA despite the use of a TNFi-biologic. In practice, most patients receive another TNFi-biologic, i.e., a second TNFi-biologic first. This is not based on solid evidence, but on arbitrary algorithms often proposed by health insurance plans, and\u002For physician experience and habit (TNFis launched 22 yrs ago vs. the first tsDMARD 8 years ago vs. first non-TNF-biologic launched 17 years ago). This study will fill a critical knowledge gap by generating CER data for important PROs between these treatment options, switching to a non-TNFi biologic or a tsDMARD in patients with active RA despite the use of a TNFi-biologic.",[876],"Rheumatoid Arthritis","2026-07-16",{"date":879,"type":880},"2026-07-17","ACTUAL",{"date":882,"type":880},"2021-09-22",{"date":884,"type":870},"2029-07-31",{"name":5,"class":6},49]