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City","Utah","84109",{"type":84,"coordinates":425},[426,427],-111.89105,40.76078,{"lat":427,"lon":426},{"facility":430,"status":318,"city":431,"state":422,"zip":432,"country":81,"countryCode":82,"cosmosGeoPoint":433,"geoPoint":437,"contacts":30},"Diabetes & Endo Treatment Spec","Sandy City","84093",{"type":84,"coordinates":434},[435,436],-111.8841,40.59161,{"lat":436,"lon":435},{"facility":439,"status":77,"city":440,"state":422,"zip":441,"country":81,"countryCode":82,"cosmosGeoPoint":442,"geoPoint":446,"contacts":30},"Chrysalis Clinical Research","St. George","84790",{"type":84,"coordinates":443},[444,445],-113.58412,37.10415,{"lat":445,"lon":444},{"facility":448,"status":77,"city":449,"state":450,"zip":451,"country":81,"countryCode":82,"cosmosGeoPoint":452,"geoPoint":456,"contacts":30},"Tidewater Physicians Multispecialty Group","Newport News","Virginia","23606",{"type":84,"coordinates":453},[454,455],-76.42975,36.98038,{"lat":455,"lon":454},{"type":458,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100655874","phase-3-research-study-on-how-people-with-type-2-diabetes-tolerate-switching-from-semaglutide-to-cagrisema-100655874",false,"NCT07817251","Research Study on How People With Type 2 Diabetes Tolerate Switching From Semaglutide to Cagrisema","Safety And Tolerability of 3 Switch Regimens From Semaglutide 1.0 mg and 2.0 mg to Co-Administered Cagrilintide and Semaglutide (Cagrisema) in Participants With Type 2 Diabetes","Inclusion criteria:\n\n* Male or female (sex assigned at birth, inclusive of all gender identities).\n* Age 18 years or above at the time of signing the informed consent.\n* Diagnosed with type 2 diabetes mellitus (T2DM) greater than or equal to (≥) 180 days before screening.\n* Stable once-weekly dose ≥ 90 days before screening of branded s.c. semaglutide. Branded semaglutide s.c. includes Ozempic and Wegovy. Participants on compounded semaglutide are ineligible.\n* Not on treatment with oral antidiabetic drugs or on stable daily dose(s) ≥ 90 days before screening of any of the following antidiabetic drug(s) or combination regimen at effective or maximum tolerated dose (MTD) as judged by the investigator: metformin and\u002For sodiumglucose co-transporter-2 (SGLT2) inhibitor.\n* Glycated haemoglobin (HbA1c) 6.5-10.5 percentage (%) (48-91 millimoles per mole \\[mmol\u002Fmol\\]) (both inclusive) as determined by central laboratory at screening.\n* Body mass index (BMI) ≥ 25 kilograms per square meter (kg\u002Fm\\^2) at screening. BMI will be calculated in the electronic case report form (eCRF) based on height and body weight at screening.\n\nExclusion criteria:\n\n* Female who is pregnant, breast-feeding or intends to become pregnant or is of childbearing potential and not using a highly effective contraceptive method from screening.\n* Renal impairment with estimated glomerular filtration rate (eGFR) less than (\\\u003C) 30 milliliter per minute per 1.73 square meter (mL\u002Fmin\u002F1.73 m\\^2) as determined by central laboratory at screening.\n* Treatment with any medication for the indication of diabetes or obesity other than stated in the inclusion criteria within 90 days before screening. However, short term insulin treatment for a maximum of 14 consecutive days and prior insulin treatment for gestational diabetes are allowed.\n* Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by an eye examination performed within 90 days before screening or in the period between screening and randomisation. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination.\n* A self-reported change in body weight \\> 5% within 90 days before screening irrespective of medical records.\n* Use of personal continuous glucose monitoring (CGM) devices. Participants currently using personal CGM devices must discontinue use prior to screening and throughout study participation.","ALL","18 Years",{"count":469,"type":470},210,"ESTIMATED","INTERVENTIONAL",[473],"PHASE3","The purpose of this clinical study is to look at the safety and tolerability of switching from semaglutide to CagriSema, for participants who have type 2 diabetes. All participants will get CagriSema, the treatment being tested. Participants will be in this clinical study for about 6 months.",[476],"Diabetes Mellitus, Type 2","2026-09-28",{"date":479,"type":480},"2026-09-30","ACTUAL",{"date":482,"type":480},"2026-09-16",{"date":484,"type":470},"2027-07-21",{"name":5,"class":6},40]