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antagonist)\n\nKey Exclusion Criteria:\n\n* Concurrent diagnosis of another form of recurrent angioedema (such as acquired angioedema, HAE with normal C1-INH (previously known as HAE Type III), idiopathic angioedema, or recurrent angioedema associated with urticaria).\n* Any clinically significant renal disease\n* Any clinically significant hepatic disease\n* Have used any of the following for long-term prevention of HAE attacks:\n\n  1. C1-INH agent (CINRYZE, HAEGARDA, RUCONEST) within 2 weeks prior to Screening.\n  2. Berotralstat (ORLADEYO) within 3 weeks prior to Screening.\n  3. Lanadelumab (TAKHZYRO) within 8 weeks prior to the Screening.\n  4. Androgen use within 12 weeks prior to Screening.\n* Received prior treatment with any RNA\u002FDNA-based therapy for HAE or intolerant to any prior RNA\u002FDNA-based therapy for any condition, excluding vaccines.","ALL","18 Years",{"count":713,"type":714},90,"ESTIMATED","INTERVENTIONAL",[717],"PHASE3","This study will evaluate the efficacy and safety of ADX-324 in participants with Type 1 or Type 2 hereditary angioedema. The study will also evaluate safety, pharmacokinetics (PK), pharmacodynamics (PD), and health-related quality of life measures.",[720,721,722,723],"Hereditary Angioedema","HAE","Hereditary Angioedema - Type 1","Hereditary Angioedema - Type 2",[721,725,726],"Hereditary angioedema","onvuzosiran","2026-09-08",{"date":729,"type":730},"2026-09-10","ACTUAL",{"date":732,"type":730},"2025-08-28",{"date":734,"type":714},"2027-12-31",{"name":5,"class":6},70]