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Truncating PKD1 mutation OR\n  2. eGFR loss \\> 3ml\u002Fmin\u002Fyear (determined by ≥ 4 creatinine values within 4 years, ≥ 6 months measurement intervals) OR\n  3. PROPKD score \\> 6 (patient history)\n* IF patient is on ACE-I \u002FARBs: stable dose for 4 weeks before screening\n\nExclusion Criteria:\n\n* Treatment with tolvaptan, somatostatin analogue, lithium or SGLT2i within the last 3 months before screening\n* Medical history of diabetic ketoacidosis, necrotizing fasciitis or organ transplantation\n* Diabetes mellitus type 1 or any type of diabetes mellitus due to insulin deficiency\n* Uncontrolled ongoing urinary tract or genital infections\n* Known intolerance of the study medication ingredients\n* Uncontrolled grade 2 hypertension (\\>160\u002F100 mmHg)\n* Symptomatic hypotension, or systolic blood pressure \\\u003C90 mmHg\n* Primary renal disease other than ADPKD\n* Hepatic impairment (aspartate transaminase \\[AST\\] or alanine transaminase \\[ALT\\]\\>3x the up-per limit of normal \\[ULN\\]; or total bilirubin \\>2x ULN at time of enrolment)\n* Pregnancy, breastfeeding or women of child-bearing potential not using effective contraception method\n* Not able to comply with the study protocol, in the investigator's judgement\n* Not able to provide informed consent\n* Participation in any other interventional clinical trial in the last 2 months","ALL","18 Years","60 Years",{"count":448,"type":449},420,"ESTIMATED","INTERVENTIONAL",[452],"PHASE3","Autosomal dominant polycystic kidney disease is the most common genetic cause of kidney failure. 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