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Hospital-London","London","SW3 6JJ",{"type":74,"coordinates":874},[875,876],-0.12574,51.50853,{"lat":876,"lon":875},[879],{"name":880,"role":61,"phone":881,"phoneExt":34,"email":882},"Naureen Starling","02078118460","gitrials@rmh.nhs.uk",{"facility":884,"status":67,"city":871,"state":34,"zip":885,"country":848,"countryCode":849,"cosmosGeoPoint":886,"geoPoint":888,"contacts":889},"Imperial College Healthcare NHS Foundation Trust, Hammersmith Hospital","W12 0HS",{"type":74,"coordinates":887},[875,876],{"lat":876,"lon":875},[890],{"name":891,"role":61,"phone":892,"phoneExt":34,"email":893},"Michela Cicchetti","0203 313 8364","michela.cicchetti@nhs.ne",{"facility":895,"status":67,"city":896,"state":34,"zip":897,"country":848,"countryCode":849,"cosmosGeoPoint":898,"geoPoint":902,"contacts":34},"The Christie NHS Foundation Trust","Manchester","M20 4BX",{"type":74,"coordinates":899},[900,901],-2.23743,53.48095,{"lat":901,"lon":900},{"type":904,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR","100612334","phase-3-study-of-daraxonrasib-rmc-6236-in-patients-with-resected-pancreatic-ductal-adenocarcinoma-pdac-100612334",false,"NCT07252232","Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)","RASolute 304: A Phase 3 Multicenter, Open-label, Randomized, 2-Arm Study of Adjuvant Daraxonrasib Versus Standard of Care Observation Following Completion of Neoadjuvant and\u002For Adjuvant Chemotherapy in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)","RASolute 304","Inclusion Criteria:\n\n* At least 18 years old and has provided informed consent.\n* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.\n* Histologically confirmed PDAC with successful (R0\u002FR1) curative intent surgical resection and no evidence of recurrent or metastatic disease.\n* Must have received perioperative (neoadjuvant, adjuvant, or a combination of both) multi-agent chemotherapy.\n* Must have completed most recent treatment within the past 12 weeks.\n* Adequate organ function (bone marrow, liver, kidney, coagulation).\n* Documented RAS mutation status.\n* Able to take oral medications.\n\nExclusion Criteria:\n\n* Prior therapy with direct RAS-targeted therapy (eg. degraders and\u002For inhibitors).\n* Any conditions that may affect the ability to take or absorb study drug.\n* Major surgery within 28 days prior to randomization.\n* Patient is unable or unwilling to comply with protocol-required study visits or procedures.","ALL","18 Years",{"count":916,"type":917},500,"ESTIMATED","INTERVENTIONAL",[920],"PHASE3","The purpose of this study is to evaluate the safety and efficacy of a novel RAS(ON) inhibitor compared to standard of care (SOC) observation 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