[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100457328":3},{"organization":4,"outcomesModule":7,"designInfo":46,"detailedDescription":53,"studyPopulation":49,"armGroups":54,"interventions":69,"overallOfficials":114,"centralContacts":49,"locations":118,"responsibleParty":3057,"collaborators":3059,"id":3063,"slug":3064,"hasResults":3065,"nctId":3066,"briefTitle":3067,"officialTitle":3068,"acronym":49,"eligibilityCriteria":3069,"healthyVolunteers":3065,"sex":3070,"minAge":49,"maxAge":3071,"enrollmentInfo":3072,"targetDuration":49,"studyType":3075,"phases":3076,"briefSummary":3078,"conditions":3079,"keywords":49,"overallStatus":121,"whyStopped":49,"lastUpdateSubmitDate":3083,"lastUpdatePostDateStruct":3084,"startDateStruct":3087,"completionDateStruct":3089,"leadSponsor":3091,"locationsCount":3092},{"fullName":5,"class":6},"Children's Oncology Group","NETWORK",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":20},[9],{"measure":10,"description":11,"timeFrame":12},"Thoracic event-free survival (tEFS)","Estimated four year thoracic event free survival (tEFS) where tEFS is calculated as the time from study enrollment to thoracic cavity event. Any recurrence within the pulmonary parenchyma, involving the pleural surface or the drain\u002Fsurgical site wound will be considered an event. A death that results from the procedure, as confirmed by the treating physician, will be considered an event. Patients with recurrences arising outside the thoracic region, the diagnosis of a malignancy that is not osteosarcoma (SMN) or death considered unrelated to the study surgical procedure, as confirmed by the treating physician will be considered competing events provided these occur prior to a thoracic cavity event as defined above. Patients without an event of any kind at last contact are considered censored.","Four years after enrollment",[14,17],{"measure":15,"description":16,"timeFrame":12},"Event free survival (EFS)","Estimated four year EFS where EFS is calculated as the time from study enrollment to disease progression, disease relapse, occurrence of a second malignant neoplasm, death from any cause or last follow-up whichever occurs first. Patients without an event at last contact are considered censored.",{"measure":18,"description":19,"timeFrame":12},"Overall survival (OS)","Time from study enrollment to death or last patient contact. Patients alive at last contact are considered censored.",[21,25,28,32,35,38,42],{"measure":22,"description":23,"timeFrame":24},"Perioperative surgical complications","The descriptions and grading scales found in the revised National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0 will be utilized for AE reporting.","At 30 days post-op",{"measure":26,"description":27,"timeFrame":12},"Mode of tEFS event","Classified as: (1) ipsilateral recurrence site; (2) contralateral recurrence site; or (3) ipsilateral and contralateral recurrence site. The analysis will be restricted to patients with unilateral disease at enrollment.",{"measure":29,"description":30,"timeFrame":31},"Use of localization techniques","Data collection will include a description of all localization methods used.","12 months after enrollment",{"measure":33,"description":34,"timeFrame":31},"Decision to change the post-operative treatment plan","Whether the investigator adhered to the post-thoracic surgery plan for systemic therapy.",{"measure":36,"description":37,"timeFrame":31},"Radiological features to the presence of viable tumor","Radiological features and pathological characteristics of lung nodules contributed by the same patient.",{"measure":39,"description":40,"timeFrame":41},"Post operative pain intensity at time point 2, 48 hours after surgical intervention","NRS 11 single item pain intensity score.","48 hours after surgical intervention",{"measure":43,"description":44,"timeFrame":45},"Frequency of obtaining quality tumor tissue for biological analysis","Tumor samples obtained from the surgical procedure that are submitted to the COG tissue bank and subjected to dual nucleic acid extraction will be classified by central review as to whether sufficient tumor content was obtained for ultra low passage whole genome sequencing.","1 month after surgical intervention",{"allocation":47,"interventionModel":48,"interventionModelDescription":49,"primaryPurpose":50,"observationalModel":49,"timePerspective":49,"maskingInfo":51},"RANDOMIZED","PARALLEL",null,"TREATMENT",{"masking":52,"maskingDescription":49,"whoMasked":49},"NONE","PRIMARY OBJECTIVE:\n\nI. To determine if open surgical resection is superior to thoracoscopic resection for thoracic event-free survival (tEFS) in patients with resectable oligometastatic pulmonary osteosarcoma.\n\nSECONDARY OBJECTIVES:\n\nI. To determine if open surgical resection is superior to thoracoscopy for event free survival (EFS) in patients with resectable oligometastatic pulmonary osteosarcoma.\n\nII. To determine if open surgical resection is superior to thoracoscopy for overall survival (OS) in patients with resectable oligometastatic pulmonary osteosarcoma.\n\nEXPLORATORY OBJECTIVES:\n\nI. To compare 30-day rates of perioperative surgical complications for both open surgical resection and thoracoscopy.\n\nII. To compare patterns of recurrence (ipsilateral and\u002For contralateral) in patients who undergo open or thoracoscopic resection for unilateral or bilateral pulmonary metastases.\n\nIII. To describe the use of localization techniques and its relationship with both surgical approach and pathologic findings.\n\nIV. To assess the prognostic significance of a decision to change the post-operative treatment plan.\n\nV. To describe the relationship between the preoperative chest computed tomography (CT) imaging, intraoperative surgical findings, and pathologic results, comparing radiological features to the presence of viable tumor.\n\nVI. To generate well-characterized, clinically-annotated, distributable models of metastatic osteosarcoma.\n\nVII. To collect and bank pulmonary metastatic lesions (including frozen tissues and paired metastatic lesions coming from the same patient) to facilitate study of metastatic disease and serial blood samples for future tumor profiling, germline and circulating tumor deoxyribonucleic acid (DNA) studies.\n\nOUTLINE: Patients are randomized into 1 of 2 arms.\n\nARM A: Patients undergo open thoracic surgery (thoracotomy).\n\nARM B: Patients undergo thoracoscopy (video-assisted thoracoscopic surgery or VATS).\n\nAll patients undergo computed tomography (CT) throughout the trial. Patients may also undergo collection of tissue on study and blood throughout the trial.\n\nAfter completion of study treatment, patients are followed up at 7-14 days, 4-6 weeks, and 3 months post-surgery and then every 3 months for up to 2 years.",[55,64],{"label":56,"type":57,"description":58,"interventionNames":59},"Arm A (thoracotomy)","EXPERIMENTAL","Patients undergo open thoracic surgery (thoracotomy). Patients undergo CT throughout the trial. Patients may also undergo collection of tissue on study and blood throughout the trial.",[60,61,62,63],"Procedure: Biospecimen Collection","Procedure: Computed Tomography","Other: Questionnaire Administration","Procedure: Thoracotomy",{"label":65,"type":57,"description":66,"interventionNames":67},"Arm B (thoracoscopy)","Patients undergo thoracoscopy (video-assisted thoracoscopic surgery or VATS). Patients undergo CT throughout the trial. Patients may also undergo collection of tissue on study and blood throughout the trial.",[60,62,68],"Procedure: Thoracoscopy",[70,79,96,101,107],{"type":71,"name":72,"description":73,"armGroupLabels":74,"otherNames":75},"PROCEDURE","Biospecimen Collection","Undergo collection of tissue and blood",[56,65],[76,77,78],"Biological Sample Collection","Biospecimen Collected","Specimen Collection",{"type":71,"name":80,"description":81,"armGroupLabels":82,"otherNames":83},"Computed Tomography","Undergo CT",[56],[84,85,86,87,88,89,90,91,92,93,94,95],"CAT","CAT Scan","Computed Axial Tomography","Computerized Axial Tomography","Computerized axial tomography (procedure)","Computerized Tomography","Computerized Tomography (CT) scan","CT","CT Scan","Diagnostic CAT Scan","Diagnostic CAT Scan Service Type","tomography",{"type":97,"name":98,"description":99,"armGroupLabels":100,"otherNames":49},"OTHER","Questionnaire Administration","Ancillary studies",[56,65],{"type":71,"name":102,"description":103,"armGroupLabels":104,"otherNames":105},"Thoracoscopy","Undergo video-assisted thoracoscopic surgery or VATS",[65],[106],"Pleuroscopy",{"type":71,"name":108,"description":109,"armGroupLabels":110,"otherNames":111},"Thoracotomy","Undergo open thoracic surgery",[56],[112,113],"incision of Chest Wall","Incision of Thorax",[115],{"name":116,"affiliation":5,"role":117},"John J Doski","PRINCIPAL_INVESTIGATOR",[119,141,157,173,187,201,215,230,246,258,270,283,295,309,323,337,345,357,372,387,402,417,431,443,454,469,485,500,515,530,539,555,571,587,597,609,623,638,647,662,677,689,705,720,736,751,762,774,788,803,817,832,848,862,877,892,907,919,934,949,964,975,987,1001,1016,1027,1042,1051,1066,1080,1090,1102,1110,1118,1130,1138,1148,1157,1169,1181,1189,1201,1215,1227,1235,1247,1259,1275,1286,1300,1315,1331,1346,1360,1372,1383,1398,1409,1422,1434,1442,1447,1456,1461,1466,1474,1482,1490,1499,1507,1516,1525,1533,1542,1548,1556,1565,1571,1579,1584,1589,1597,1605,1613,1622,1631,1639,1647,1653,1662,1671,1680,1692,1706,1715,1721,1727,1743,1758,1772,1788,1799,1814,1830,1845,1859,1873,1886,1898,1910,1921,1935,1949,1964,1972,1982,1990,2004,2009,2025,2040,2054,2069,2083,2099,2114,2129,2143,2155,2170,2184,2199,2215,2230,2242,2258,2273,2287,2301,2316,2331,2347,2361,2373,2389,2404,2419,2433,2444,2454,2469,2484,2498,2510,2525,2540,2555,2566,2581,2593,2604,2619,2629,2645,2660,2675,2689,2700,2715,2725,2739,2753,2768,2783,2795,2809,2825,2841,2850,2865,2880,2892,2902,2912,2930,2945,2961,2977,2989,3004,3021,3035,3046],{"facility":120,"status":121,"city":122,"state":123,"zip":124,"country":125,"countryCode":126,"cosmosGeoPoint":127,"geoPoint":132,"contacts":133},"Children's Hospital of Alabama","RECRUITING","Birmingham","Alabama","35233","United States","US",{"type":128,"coordinates":129},"Point",[130,131],-86.80249,33.52066,{"lat":131,"lon":130},[134,139],{"name":135,"role":136,"phone":137,"phoneExt":49,"email":138},"Site Public Contact","CONTACT","205-638-9285","oncologyresearch@peds.uab.edu",{"name":140,"role":117,"phone":49,"phoneExt":49,"email":49},"Jamie M. Aye",{"facility":142,"status":121,"city":143,"state":144,"zip":145,"country":125,"countryCode":126,"cosmosGeoPoint":146,"geoPoint":150,"contacts":151},"Providence Alaska Medical Center","Anchorage","Alaska","99508",{"type":128,"coordinates":147},[148,149],-149.90028,61.21806,{"lat":149,"lon":148},[152,155],{"name":135,"role":136,"phone":153,"phoneExt":49,"email":154},"907-212-6871","AKPAMC.OncologyResearchSupport@providence.org",{"name":156,"role":117,"phone":49,"phoneExt":49,"email":49},"Brenda J. Wittman",{"facility":158,"status":121,"city":159,"state":160,"zip":161,"country":125,"countryCode":126,"cosmosGeoPoint":162,"geoPoint":166,"contacts":167},"Kingman Regional Medical Center","Kingman","Arizona","86401",{"type":128,"coordinates":163},[164,165],-114.05301,35.18944,{"lat":165,"lon":164},[168,171],{"name":135,"role":136,"phone":169,"phoneExt":49,"email":170},"702-384-0013","research@sncrf.org",{"name":172,"role":117,"phone":49,"phoneExt":49,"email":49},"Alan K. Ikeda",{"facility":174,"status":121,"city":175,"state":160,"zip":176,"country":125,"countryCode":126,"cosmosGeoPoint":177,"geoPoint":181,"contacts":182},"Banner Children's at Desert","Mesa","85202",{"type":128,"coordinates":178},[179,180],-111.82264,33.42227,{"lat":180,"lon":179},[183,185],{"name":135,"role":136,"phone":184,"phoneExt":49,"email":49},"480-412-3100",{"name":186,"role":117,"phone":49,"phoneExt":49,"email":49},"Joseph C. Torkildson",{"facility":188,"status":121,"city":189,"state":160,"zip":190,"country":125,"countryCode":126,"cosmosGeoPoint":191,"geoPoint":195,"contacts":196},"Phoenix Childrens Hospital","Phoenix","85016",{"type":128,"coordinates":192},[193,194],-112.07404,33.44838,{"lat":194,"lon":193},[197,199],{"name":135,"role":136,"phone":198,"phoneExt":49,"email":49},"602-546-0920",{"name":200,"role":117,"phone":49,"phoneExt":49,"email":49},"Alok K. Kothari",{"facility":202,"status":121,"city":203,"state":160,"zip":204,"country":125,"countryCode":126,"cosmosGeoPoint":205,"geoPoint":209,"contacts":210},"Banner University Medical Center - Tucson","Tucson","85719",{"type":128,"coordinates":206},[207,208],-110.92648,32.22174,{"lat":208,"lon":207},[211,213],{"name":135,"role":136,"phone":49,"phoneExt":49,"email":212},"UACC-IIT@uacc.arizona.edu",{"name":214,"role":117,"phone":49,"phoneExt":49,"email":49},"Michelina de la Maza",{"facility":216,"status":121,"city":217,"state":218,"zip":219,"country":125,"countryCode":126,"cosmosGeoPoint":220,"geoPoint":224,"contacts":225},"Arkansas Children's Hospital","Little Rock","Arkansas","72202-3591",{"type":128,"coordinates":221},[222,223],-92.28959,34.74648,{"lat":223,"lon":222},[226,228],{"name":135,"role":136,"phone":227,"phoneExt":49,"email":49},"501-364-7373",{"name":229,"role":117,"phone":49,"phoneExt":49,"email":49},"Michael W. Bishop",{"facility":231,"status":121,"city":232,"state":233,"zip":234,"country":125,"countryCode":126,"cosmosGeoPoint":235,"geoPoint":239,"contacts":240},"Kaiser Permanente-Anaheim","Anaheim","California","92806",{"type":128,"coordinates":236},[237,238],-117.9145,33.83529,{"lat":238,"lon":237},[241,244],{"name":135,"role":136,"phone":242,"phoneExt":49,"email":243},"800-398-3996","clinical.trials@kp.org",{"name":245,"role":117,"phone":49,"phoneExt":49,"email":49},"Robert M. Cooper",{"facility":247,"status":121,"city":248,"state":233,"zip":249,"country":125,"countryCode":126,"cosmosGeoPoint":250,"geoPoint":254,"contacts":255},"PCR Oncology","Arroyo Grande","93420",{"type":128,"coordinates":251},[252,253],-120.59073,35.11859,{"lat":253,"lon":252},[256,257],{"name":135,"role":136,"phone":169,"phoneExt":49,"email":170},{"name":172,"role":117,"phone":49,"phoneExt":49,"email":49},{"facility":259,"status":121,"city":260,"state":233,"zip":261,"country":125,"countryCode":126,"cosmosGeoPoint":262,"geoPoint":266,"contacts":267},"Kaiser Permanente-Bellflower","Bellflower","90706",{"type":128,"coordinates":263},[264,265],-118.11701,33.88168,{"lat":265,"lon":264},[268,269],{"name":135,"role":136,"phone":242,"phoneExt":49,"email":243},{"name":245,"role":117,"phone":49,"phoneExt":49,"email":49},{"facility":271,"status":121,"city":272,"state":233,"zip":273,"country":125,"countryCode":126,"cosmosGeoPoint":274,"geoPoint":278,"contacts":279},"Kaiser Permanente Downey Medical Center","Downey","90242",{"type":128,"coordinates":275},[276,277],-118.13257,33.94001,{"lat":277,"lon":276},[280,282],{"name":135,"role":136,"phone":281,"phoneExt":49,"email":49},"626-564-3455",{"name":245,"role":117,"phone":49,"phoneExt":49,"email":49},{"facility":284,"status":121,"city":285,"state":233,"zip":286,"country":125,"countryCode":126,"cosmosGeoPoint":287,"geoPoint":291,"contacts":292},"Kaiser Permanente-Fontana","Fontana","92335",{"type":128,"coordinates":288},[289,290],-117.43505,34.09223,{"lat":290,"lon":289},[293,294],{"name":135,"role":136,"phone":242,"phoneExt":49,"email":243},{"name":245,"role":117,"phone":49,"phoneExt":49,"email":49},{"facility":296,"status":121,"city":297,"state":233,"zip":298,"country":125,"countryCode":126,"cosmosGeoPoint":299,"geoPoint":303,"contacts":304},"Loma Linda University Medical Center","Loma Linda","92354",{"type":128,"coordinates":300},[301,302],-117.26115,34.04835,{"lat":302,"lon":301},[305,307],{"name":135,"role":136,"phone":306,"phoneExt":49,"email":49},"909-558-4050",{"name":308,"role":117,"phone":49,"phoneExt":49,"email":49},"Albert Kheradpour",{"facility":310,"status":121,"city":311,"state":233,"zip":312,"country":125,"countryCode":126,"cosmosGeoPoint":313,"geoPoint":317,"contacts":318},"Miller Children's and Women's Hospital Long Beach","Long Beach","90806",{"type":128,"coordinates":314},[315,316],-118.18923,33.76696,{"lat":316,"lon":315},[319,321],{"name":135,"role":136,"phone":320,"phoneExt":49,"email":49},"562-933-5600",{"name":322,"role":117,"phone":49,"phoneExt":49,"email":49},"Jacqueline N. Casillas",{"facility":324,"status":121,"city":325,"state":233,"zip":326,"country":125,"countryCode":126,"cosmosGeoPoint":327,"geoPoint":331,"contacts":332},"Children's Hospital Los Angeles","Los Angeles","90027",{"type":128,"coordinates":328},[329,330],-118.24368,34.05223,{"lat":330,"lon":329},[333,335],{"name":135,"role":136,"phone":334,"phoneExt":49,"email":49},"323-361-4110",{"name":336,"role":117,"phone":49,"phoneExt":49,"email":49},"Fariba Navid",{"facility":338,"status":121,"city":325,"state":233,"zip":326,"country":125,"countryCode":126,"cosmosGeoPoint":339,"geoPoint":341,"contacts":342},"Kaiser Permanente Los Angeles Medical Center",{"type":128,"coordinates":340},[329,330],{"lat":330,"lon":329},[343,344],{"name":135,"role":136,"phone":242,"phoneExt":49,"email":243},{"name":245,"role":117,"phone":49,"phoneExt":49,"email":49},{"facility":346,"status":121,"city":325,"state":233,"zip":347,"country":125,"countryCode":126,"cosmosGeoPoint":348,"geoPoint":350,"contacts":351},"Cedars-Sinai Medical Center","90048",{"type":128,"coordinates":349},[329,330],{"lat":330,"lon":329},[352,355],{"name":135,"role":136,"phone":353,"phoneExt":49,"email":354},"310-423-2133","Cancer.trial.info@cshs.org",{"name":356,"role":117,"phone":49,"phoneExt":49,"email":49},"Leo Mascarenhas",{"facility":358,"status":121,"city":359,"state":233,"zip":360,"country":125,"countryCode":126,"cosmosGeoPoint":361,"geoPoint":365,"contacts":366},"Valley Children's Hospital","Madera","93636",{"type":128,"coordinates":362},[363,364],-120.06072,36.96134,{"lat":364,"lon":363},[367,370],{"name":135,"role":136,"phone":368,"phoneExt":49,"email":369},"559-353-3000","Research@valleychildrens.org",{"name":371,"role":117,"phone":49,"phoneExt":49,"email":49},"Ruetima Titapiwatanakun",{"facility":373,"status":121,"city":374,"state":233,"zip":375,"country":125,"countryCode":126,"cosmosGeoPoint":376,"geoPoint":380,"contacts":381},"Kaiser Permanente-Oakland","Oakland","94611",{"type":128,"coordinates":377},[378,379],-122.2708,37.80437,{"lat":379,"lon":378},[382,385],{"name":135,"role":136,"phone":383,"phoneExt":49,"email":384},"877-642-4691","Kpoct@kp.org",{"name":386,"role":117,"phone":49,"phoneExt":49,"email":49},"Aarati V. Rao",{"facility":388,"status":121,"city":389,"state":233,"zip":390,"country":125,"countryCode":126,"cosmosGeoPoint":391,"geoPoint":395,"contacts":396},"Children's Hospital of Orange County","Orange","92868",{"type":128,"coordinates":392},[393,394],-117.85311,33.78779,{"lat":394,"lon":393},[397,400],{"name":135,"role":136,"phone":398,"phoneExt":49,"email":399},"714-509-8646","oncresearch@choc.org",{"name":401,"role":117,"phone":49,"phoneExt":49,"email":49},"Elyssa M. Rubin",{"facility":403,"status":121,"city":404,"state":233,"zip":405,"country":125,"countryCode":126,"cosmosGeoPoint":406,"geoPoint":410,"contacts":411},"Lucile Packard Children's Hospital Stanford University","Palo Alto","94304",{"type":128,"coordinates":407},[408,409],-122.14302,37.44188,{"lat":409,"lon":408},[412,415],{"name":135,"role":136,"phone":413,"phoneExt":49,"email":414},"800-694-0012","ccto-office@stanford.edu",{"name":416,"role":117,"phone":49,"phoneExt":49,"email":49},"Jay Michael S. Balagtas",{"facility":418,"status":121,"city":419,"state":233,"zip":420,"country":125,"countryCode":126,"cosmosGeoPoint":421,"geoPoint":425,"contacts":426},"University of California Davis Comprehensive Cancer Center","Sacramento","95817",{"type":128,"coordinates":422},[423,424],-121.4944,38.58157,{"lat":424,"lon":423},[427,429],{"name":135,"role":136,"phone":428,"phoneExt":49,"email":49},"916-734-3089",{"name":430,"role":117,"phone":49,"phoneExt":49,"email":49},"Marcio H. Malogolowkin",{"facility":432,"status":121,"city":433,"state":233,"zip":434,"country":125,"countryCode":126,"cosmosGeoPoint":435,"geoPoint":439,"contacts":440},"Kaiser Permanente-San Diego Zion","San Diego","92120",{"type":128,"coordinates":436},[437,438],-117.16472,32.71571,{"lat":438,"lon":437},[441,442],{"name":135,"role":136,"phone":242,"phoneExt":49,"email":243},{"name":245,"role":117,"phone":49,"phoneExt":49,"email":49},{"facility":444,"status":121,"city":433,"state":233,"zip":445,"country":125,"countryCode":126,"cosmosGeoPoint":446,"geoPoint":448,"contacts":449},"Rady Children's Hospital - San Diego","92123",{"type":128,"coordinates":447},[437,438],{"lat":438,"lon":437},[450,452],{"name":135,"role":136,"phone":451,"phoneExt":49,"email":49},"858-966-5934",{"name":453,"role":117,"phone":49,"phoneExt":49,"email":49},"William D. 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Mark",{"facility":2676,"status":121,"city":2677,"state":2632,"zip":2678,"country":125,"countryCode":126,"cosmosGeoPoint":2679,"geoPoint":2683,"contacts":2684},"VCU Massey Cancer Center at Stony Point","Richmond","23235",{"type":128,"coordinates":2680},[2681,2682],-77.46026,37.55376,{"lat":2682,"lon":2681},[2685,2687],{"name":135,"role":136,"phone":49,"phoneExt":49,"email":2686},"ctoclinops@vcu.edu",{"name":2688,"role":117,"phone":49,"phoneExt":49,"email":49},"Laura Boomer",{"facility":2690,"status":121,"city":2677,"state":2632,"zip":2691,"country":125,"countryCode":126,"cosmosGeoPoint":2692,"geoPoint":2694,"contacts":2695},"VCU Massey Comprehensive Cancer Center","23298",{"type":128,"coordinates":2693},[2681,2682],{"lat":2682,"lon":2681},[2696,2699],{"name":135,"role":136,"phone":2697,"phoneExt":49,"email":2698},"804-628-6430","CTOclinops@vcu.edu",{"name":2688,"role":117,"phone":49,"phoneExt":49,"email":49},{"facility":2701,"status":121,"city":2702,"state":2632,"zip":2703,"country":125,"countryCode":126,"cosmosGeoPoint":2704,"geoPoint":2708,"contacts":2709},"Carilion Children's","Roanoke","24014",{"type":128,"coordinates":2705},[2706,2707],-79.94143,37.27097,{"lat":2707,"lon":2706},[2710,2713],{"name":135,"role":136,"phone":2711,"phoneExt":49,"email":2712},"540-266-6238","wpmccarty@carilionclinic.org",{"name":2714,"role":117,"phone":49,"phoneExt":49,"email":49},"Erwood G. Edwards",{"facility":2716,"status":1082,"city":2717,"state":2718,"zip":2719,"country":125,"countryCode":126,"cosmosGeoPoint":2720,"geoPoint":2724,"contacts":49},"Overlake Medical Center","Bellevue","Washington","98004",{"type":128,"coordinates":2721},[2722,2723],-122.20068,47.61038,{"lat":2723,"lon":2722},{"facility":2726,"status":121,"city":2727,"state":2718,"zip":2728,"country":125,"countryCode":126,"cosmosGeoPoint":2729,"geoPoint":2733,"contacts":2734},"Valley Medical Center","Renton","98055",{"type":128,"coordinates":2730},[2731,2732],-122.21707,47.48288,{"lat":2732,"lon":2731},[2735,2738],{"name":135,"role":136,"phone":2736,"phoneExt":49,"email":2737},"425-228-3440","research@valleymed.org",{"name":172,"role":117,"phone":49,"phoneExt":49,"email":49},{"facility":2740,"status":121,"city":2741,"state":2718,"zip":2742,"country":125,"countryCode":126,"cosmosGeoPoint":2743,"geoPoint":2747,"contacts":2748},"Seattle Children's Hospital","Seattle","98105",{"type":128,"coordinates":2744},[2745,2746],-122.33207,47.60621,{"lat":2746,"lon":2745},[2749,2751],{"name":135,"role":136,"phone":2750,"phoneExt":49,"email":49},"866-987-2000",{"name":2752,"role":117,"phone":49,"phoneExt":49,"email":49},"Sarah E. Leary",{"facility":2754,"status":121,"city":2755,"state":2718,"zip":2756,"country":125,"countryCode":126,"cosmosGeoPoint":2757,"geoPoint":2761,"contacts":2762},"Providence Sacred Heart Medical Center and Children's Hospital","Spokane","99204",{"type":128,"coordinates":2758},[2759,2760],-117.42908,47.65966,{"lat":2760,"lon":2759},[2763,2766],{"name":135,"role":136,"phone":2764,"phoneExt":49,"email":2765},"800-228-6618","HopeBeginsHere@providence.org",{"name":2767,"role":117,"phone":49,"phoneExt":49,"email":49},"Judy L. Felgenhauer",{"facility":2769,"status":121,"city":2770,"state":2718,"zip":2771,"country":125,"countryCode":126,"cosmosGeoPoint":2772,"geoPoint":2776,"contacts":2777},"Mary Bridge Children's Hospital and Health Center","Tacoma","98405",{"type":128,"coordinates":2773},[2774,2775],-122.44429,47.25288,{"lat":2775,"lon":2774},[2778,2781],{"name":135,"role":136,"phone":2779,"phoneExt":49,"email":2780},"253-403-1461","research@multicare.org",{"name":2782,"role":117,"phone":49,"phoneExt":49,"email":49},"Robert G. Irwin",{"facility":2784,"status":121,"city":2770,"state":2718,"zip":2785,"country":125,"countryCode":126,"cosmosGeoPoint":2786,"geoPoint":2788,"contacts":2789},"Madigan Army Medical Center","98431",{"type":128,"coordinates":2787},[2774,2775],{"lat":2775,"lon":2774},[2790,2793],{"name":135,"role":136,"phone":2791,"phoneExt":49,"email":2792},"253-968-6144","melissa.a.forouhar.mil@health.mil",{"name":2794,"role":117,"phone":49,"phoneExt":49,"email":49},"Melissa A. Forouhar",{"facility":2796,"status":121,"city":2797,"state":2718,"zip":2798,"country":125,"countryCode":126,"cosmosGeoPoint":2799,"geoPoint":2803,"contacts":2804},"North Star Lodge Cancer Center at Yakima Valley Memorial Hospital","Yakima","98902",{"type":128,"coordinates":2800},[2801,2802],-120.5059,46.60207,{"lat":2802,"lon":2801},[2805,2808],{"name":135,"role":136,"phone":2806,"phoneExt":49,"email":2807},"509-574-3535","Memorial-ClinicalTrials@yvmh.org",{"name":172,"role":117,"phone":49,"phoneExt":49,"email":49},{"facility":2810,"status":121,"city":2811,"state":2812,"zip":2813,"country":125,"countryCode":126,"cosmosGeoPoint":2814,"geoPoint":2818,"contacts":2819},"West Virginia University Healthcare","Morgantown","West Virginia","26506",{"type":128,"coordinates":2815},[2816,2817],-79.9559,39.62953,{"lat":2817,"lon":2816},[2820,2823],{"name":135,"role":136,"phone":2821,"phoneExt":49,"email":2822},"304-293-7374","cancertrialsinfo@hsc.wvu.edu",{"name":2824,"role":117,"phone":49,"phoneExt":49,"email":49},"Ashley E. Meyer",{"facility":2826,"status":121,"city":2827,"state":2828,"zip":2829,"country":125,"countryCode":126,"cosmosGeoPoint":2830,"geoPoint":2834,"contacts":2835},"University of Wisconsin Carbone Cancer Center - Eastpark Medical Center","Madison","Wisconsin","53718",{"type":128,"coordinates":2831},[2832,2833],-89.40123,43.07305,{"lat":2833,"lon":2832},[2836,2839],{"name":135,"role":136,"phone":2837,"phoneExt":49,"email":2838},"800-622-8922","clinicaltrials@cancer.wisc.edu",{"name":2840,"role":117,"phone":49,"phoneExt":49,"email":49},"Margo L. Hoover-Regan",{"facility":2842,"status":121,"city":2827,"state":2828,"zip":2843,"country":125,"countryCode":126,"cosmosGeoPoint":2844,"geoPoint":2846,"contacts":2847},"University of Wisconsin Carbone Cancer Center - University Hospital","53792",{"type":128,"coordinates":2845},[2832,2833],{"lat":2833,"lon":2832},[2848,2849],{"name":135,"role":136,"phone":2837,"phoneExt":49,"email":2838},{"name":2840,"role":117,"phone":49,"phoneExt":49,"email":49},{"facility":2851,"status":121,"city":2852,"state":2828,"zip":2853,"country":125,"countryCode":126,"cosmosGeoPoint":2854,"geoPoint":2858,"contacts":2859},"Marshfield Medical Center-Marshfield","Marshfield","54449",{"type":128,"coordinates":2855},[2856,2857],-90.1718,44.66885,{"lat":2857,"lon":2856},[2860,2863],{"name":135,"role":136,"phone":2861,"phoneExt":49,"email":2862},"800-782-8581","oncology.clinical.trials@marshfieldresearch.org",{"name":2864,"role":117,"phone":49,"phoneExt":49,"email":49},"Michelle A. Manalang",{"facility":2866,"status":121,"city":2867,"state":2828,"zip":2868,"country":125,"countryCode":126,"cosmosGeoPoint":2869,"geoPoint":2873,"contacts":2874},"Children's Hospital of Wisconsin","Milwaukee","53226",{"type":128,"coordinates":2870},[2871,2872],-87.90647,43.0389,{"lat":2872,"lon":2871},[2875,2878],{"name":135,"role":136,"phone":2876,"phoneExt":49,"email":2877},"414-955-4727","MACCCTO@mcw.edu",{"name":2879,"role":117,"phone":49,"phoneExt":49,"email":49},"Nathan J. 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Lewis",{"facility":2931,"status":121,"city":2932,"state":2915,"zip":2933,"country":2917,"countryCode":2918,"cosmosGeoPoint":2934,"geoPoint":2938,"contacts":2939},"University of Alberta Hospital","Edmonton","T6G 2B7",{"type":128,"coordinates":2935},[2936,2937],-113.46871,53.55014,{"lat":2937,"lon":2936},[2940,2943],{"name":135,"role":136,"phone":2941,"phoneExt":49,"email":2942},"780-407-8798","pedsoncologyresearch@ahs.ca",{"name":2944,"role":117,"phone":49,"phoneExt":49,"email":49},"Sarah J. McKillop",{"facility":2946,"status":121,"city":2947,"state":2948,"zip":2949,"country":2917,"countryCode":2918,"cosmosGeoPoint":2950,"geoPoint":2954,"contacts":2955},"IWK Health Centre","Halifax","Nova Scotia","B3K 6R8",{"type":128,"coordinates":2951},[2952,2953],-63.57688,44.64269,{"lat":2953,"lon":2952},[2956,2959],{"name":135,"role":136,"phone":2957,"phoneExt":49,"email":2958},"902-470-8520","Research@iwk.nshealth.ca",{"name":2960,"role":117,"phone":49,"phoneExt":49,"email":49},"Chelsea Ash",{"facility":2962,"status":121,"city":2963,"state":2964,"zip":2965,"country":2917,"countryCode":2918,"cosmosGeoPoint":2966,"geoPoint":2970,"contacts":2971},"The Montreal Children's Hospital of the MUHC","Montreal","Quebec","H3H 1P3",{"type":128,"coordinates":2967},[2968,2969],-73.58781,45.50884,{"lat":2969,"lon":2968},[2972,2975],{"name":135,"role":136,"phone":2973,"phoneExt":49,"email":2974},"514-412-4445","info@thechildren.com",{"name":2976,"role":117,"phone":49,"phoneExt":49,"email":49},"Stephanie Mourad",{"facility":2978,"status":121,"city":2963,"state":2964,"zip":2979,"country":2917,"countryCode":2918,"cosmosGeoPoint":2980,"geoPoint":2982,"contacts":2983},"Centre Hospitalier Universitaire Sainte-Justine","H3T 1C5",{"type":128,"coordinates":2981},[2968,2969],{"lat":2969,"lon":2968},[2984,2987],{"name":135,"role":136,"phone":2985,"phoneExt":49,"email":2986},"514-345-4931","yvan.samson@umontreal.ca",{"name":2988,"role":117,"phone":49,"phoneExt":49,"email":49},"Monia Marzouki",{"facility":2990,"status":121,"city":2991,"state":2964,"zip":2992,"country":2917,"countryCode":2918,"cosmosGeoPoint":2993,"geoPoint":2997,"contacts":2998},"Centre Hospitalier Universitaire de Sherbrooke-Fleurimont","Sherbrooke","J1H 5N4",{"type":128,"coordinates":2994},[2995,2996],-71.89908,45.40008,{"lat":2996,"lon":2995},[2999,3002],{"name":135,"role":136,"phone":3000,"phoneExt":49,"email":3001},"819-820-6480","crcinformation.chus@ssss.gouv.qc.ca",{"name":3003,"role":117,"phone":49,"phoneExt":49,"email":49},"Josee Brossard",{"facility":3005,"status":121,"city":3006,"state":3007,"zip":3008,"country":3009,"countryCode":3010,"cosmosGeoPoint":3011,"geoPoint":3015,"contacts":3016},"Starship Children's Hospital","Grafton","Auckland","1145","New Zealand","NZ",{"type":128,"coordinates":3012},[3013,3014],174.76566,-36.86029,{"lat":3014,"lon":3013},[3017,3019],{"name":135,"role":136,"phone":3018,"phoneExt":49,"email":49},"0800 728 436",{"name":3020,"role":117,"phone":49,"phoneExt":49,"email":49},"Mandy PohLui de Silva",{"facility":3022,"status":121,"city":3023,"state":49,"zip":3024,"country":3009,"countryCode":3010,"cosmosGeoPoint":3025,"geoPoint":3029,"contacts":3030},"Christchurch Hospital","Christchurch","8011",{"type":128,"coordinates":3026},[3027,3028],172.63333,-43.53333,{"lat":3028,"lon":3027},[3031,3033],{"name":135,"role":136,"phone":3032,"phoneExt":49,"email":49},"03 364 0640",{"name":3034,"role":117,"phone":49,"phoneExt":49,"email":49},"Tristan Pettit",{"facility":3036,"status":589,"city":3037,"state":49,"zip":3038,"country":3039,"countryCode":3040,"cosmosGeoPoint":3041,"geoPoint":3045,"contacts":49},"HIMA San Pablo Oncologic Hospital","Caguas","00726","Puerto Rico","PR",{"type":128,"coordinates":3042},[3043,3044],-66.0485,18.23412,{"lat":3044,"lon":3043},{"facility":3047,"status":1082,"city":3048,"state":49,"zip":3049,"country":3050,"countryCode":3051,"cosmosGeoPoint":3052,"geoPoint":3056,"contacts":49},"King Faisal Specialist Hospital and Research Centre","Riyadh","11211","Saudi Arabia","SA",{"type":128,"coordinates":3053},[3054,3055],46.72185,24.68773,{"lat":3055,"lon":3054},{"type":3058,"investigatorFullName":49,"investigatorTitle":49,"investigatorAffiliation":49,"oldNameTitle":49,"oldOrganization":49},"SPONSOR",[3060],{"name":3061,"class":3062},"National Cancer Institute (NCI)","NIH","100457328","phase-3-thoracotomy-versus-thoracoscopic-management-of-pulmonary-metastases-in-patients-with-osteosarcoma-100457328",false,"NCT05235165","Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma","A Phase 3 Randomized Controlled Trial Comparing Open vs Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma","Inclusion Criteria:\n\n* Patients must be \\\u003C 50 years at the time of enrollment.\n* Patients must have =\\\u003C 4 nodules per lung consistent with or suspicious for metastases, with at least one of which being \\>= 3 mm and all of which must be =\\\u003C 3 cm size.\n\n  * Note: Patient must have eligibility confirmed by rapid central imaging review.\n* Lung nodules must be considered resectable by either open thoracotomy or thoracoscopic surgery. Determination of resectability is made by the institutional surgeon.\n* Patients must have a histological diagnosis of osteosarcoma.\n* Patients must have evidence of metastatic lung disease at the time of initial diagnosis, or at time of 1st recurrence following completion of therapy for initially localized disease.\n* Patients with newly diagnosed disease must have completed successful gross tumor resection for their primary tumor or surgical local control of primary tumor must be planned to be performed simultaneously with thoracic surgery.\n* Newly diagnosed patients must be receiving or recently completed (within 60 days) systemic therapy considered by the treating physician to be standard treatment for newly diagnosed osteosarcoma (eg, cisplatin-doxorubicin or ifosfamide-based drug regimens) at the time of enrollment on this study. Dose and drug modifications for toxicity do not exclude patients from participation.\n* Patients at time of 1st recurrence must have completed systemic therapy for their initial primary tumor, considered by the treating physician to be standard treatment for newly diagnosed osteosarcoma (eg, cisplatin-doxorubicin or ifosfamide-based drug regimens) at the time of enrollment on this study. Dose and drug modifications for toxicity do not exclude patients from participation.\n\nExclusion Criteria:\n\n* Patients with unresectable primary tumor.\n* Patients with pulmonary metastatic lesions that would require anatomic resection (lobectomy or pneumonectomy) or lesions that are defined as \"central\" (i.e., central lesion involves or is proximal to segmental bronchi and peripheral is lesion distal to segmental bronchi).\n* Patients with chest wall or mediastinal based metastatic lesions, or with significant pleural effusion.\n* Patients with disease progression at either the primary or pulmonary metastatic site while on initial therapy. Note: Once the patient has been enrolled on the study, additional computed tomography (CT) scans are not anticipated prior to thoracic surgery. Note: Some variation in nodule size measurements over the course of pre-operative therapy is anticipated and does not qualify for exclusion unless deemed true disease progression by the primary treatment team.\n* Patients with evidence of extrapulmonary metastatic disease.\n* Patients who received therapeutic pulmonary surgery for lung metastasis prior to enrollment.\n* All patients and\u002For their parents or legal guardians must sign a written informed consent.\n* All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met.","ALL","50 Years",{"count":3073,"type":3074},62,"ESTIMATED","INTERVENTIONAL",[3077],"PHASE3","This phase III trial compares the effect of open thoracic surgery (thoracotomy) to thoracoscopic surgery (video-assisted thoracoscopic surgery or VATS) in treating patients with osteosarcoma that has spread to the lung (pulmonary metastases). Open thoracic surgery is a type of surgery done through a single larger incision (like a large cut) that goes between the ribs, opens up the chest, and removes the cancer. Thoracoscopy is a type of chest surgery where the doctor makes several small incisions and uses a small camera to help with removing the cancer. This trial is being done evaluate the two different surgery methods for patients with osteosarcoma that has spread to the lung to find out which is better.",[3080,3081,3082],"Metastatic Malignant Neoplasm in the Lung","Metastatic Osteosarcoma","Osteosarcoma","2026-08-21",{"date":3085,"type":3086},"2026-08-25","ACTUAL",{"date":3088,"type":3086},"2022-04-01",{"date":3090,"type":3074},"2031-03-31",{"name":5,"class":6},233]