[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651600":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":25,"responsibleParty":41,"collaborators":25,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":45,"sex":51,"minAge":52,"maxAge":25,"enrollmentInfo":53,"targetDuration":25,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":64,"whyStopped":25,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":25},{"fullName":5,"class":6},"Erasme University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Single bolus injection","ACTIVE_COMPARATOR","Patient will receive their propofol induction dose in a single bolus injection.",[13],"Other: Bolus injection",{"label":15,"type":16,"description":17,"interventionNames":18},"Fractionned injection","EXPERIMENTAL","Patients will receive 20 mg of propofol followed by the remaining dose of propofol 30-40 seconds later.",[19],"Other: Fractionned onjection",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Bolus injection","During Months 1, 3, 5 and 7 patients will receive a full single bolus of propofol",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Fractionned onjection","During Months 2, 4, 6 and 8 patients will receive the same total dose but delivered in two sequential injections: an initial subdose (e.g., 20 mg), followed by the remainder of the dose after a brief interval (e.g., 30 seconds).",[15],[31],{"name":32,"affiliation":33,"role":34},"Alexandre Joosten, MD, PhD","Department of Anesthesiology & Perioperative Medecine, Ronald Reagan Medical Center, University of California Los Angeles, USA","STUDY_DIRECTOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Denis Schmartz, MD","CONTACT","+3225553324","denis.schmartz@hubruxelles.be",{"type":42,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100651600","phase-4-a-novel-two-step-dosing-induction-strategy-the-propofol-challenge-test-to-minimize-propofol-injection-pain-100651600",false,"NCT07763548","A Novel Two-Step Dosing Induction Strategy (The Propofol Challenge Test) to Minimize Propofol Injection Pain","A Novel Two-Step Dosing Induction Strategy (The Propofol Challenge Test) to Minimize Propofol Injection Pain: A Time-block-Allocated Comparative Effectiveness Study","PROTECT","Inclusion Criteria:\n\n* Adults ≥18 years old.\n* Undergoing non cardiac surgery under general anesthesia.\n* Receiving propofol for induction.\n* No midazolam premedication\n* 20g IV Catheter below the antecubital fossa used for induction of anesthesia\n\nExclusion Criteria:\n\n* Emergency surgery.\n* Inability to communicate (language or cognitive impairment).\n* Pre-induction IV analgesia administration or patients under preoperatively\n* Patient with dementia, Alzheimer or other uncontrolled psychiatric diseases that would impact their ability to willingly participate","ALL","18 Years",{"count":54,"type":55},2000,"ESTIMATED","INTERVENTIONAL",[58],"PHASE4","Propofol is the most widely used intravenous hypnotic agent for the induction of general anesthesia owing to its rapid onset and short duration of action. Despite its favorable pharmacokinetics and widespread use, a notable drawback persists: the incidence of pain on injection. Statistics on the matter are widely variable, but some estimates indicate that the incidence of pain with propofol injection is around 70%1.\n\nTo date, no studies have systematically evaluated whether dividing the induction dose of propofol-starting with a small sub-induction bolus (e.g., 20 mg) followed by the remainder-can reduce pain perception.\n\nWe hypothesize that a two-step administration of propofol-consisting of a small initial dose followed by the remaining dose-may serve as a nociceptive preconditioning stimulus and reduce postoperative patient-recalled injection pain compared to standard single-bolus administration.",[61],"Any Patient Under General Anesthesia With Propofol Induction",[63],"Propofol, pain,","NOT_YET_RECRUITING","2026-08-10",{"date":67,"type":68},"2026-08-13","ACTUAL",{"date":70,"type":55},"2026-10-02",{"date":72,"type":55},"2028-06-30",{"name":5,"class":6}]