[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651300":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":39,"centralContacts":44,"locations":53,"responsibleParty":77,"collaborators":30,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":30,"eligibilityCriteria":85,"healthyVolunteers":81,"sex":86,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":30,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":99,"overallStatus":56,"whyStopped":30,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"Xi'an Aerospace General Hospital","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Propofol Group","EXPERIMENTAL","Participants in this arm will receive propofol for anesthesia induction and maintenance during elective laparoscopic cholecystectomy. All participants will also receive standardized perioperative care, including prophylactic antiemetics (ondansetron 8 mg and dexamethasone 10 mg), intraoperative analgesia with sufentanil and remifentanil, cisatracurium for neuromuscular blockade, ultrasound-guided transversus abdominis plane (TAP) block with 0.3% ropivacaine, and postoperative patient-controlled intravenous analgesia (PCIA). The primary and secondary outcomes will be assessed within 24 hours after surgery.",[13],"Drug: Propofol",{"label":15,"type":10,"description":16,"interventionNames":17},"Ciprofol Group","Participants in this arm will receive ciprofol, a novel cyclopropyl analogue of propofol, for anesthesia induction and maintenance during elective laparoscopic cholecystectomy. All participants will also receive standardized perioperative care, including prophylactic antiemetics (ondansetron 8 mg and dexamethasone 10 mg), intraoperative analgesia with sufentanil and remifentanil, cisatracurium for neuromuscular blockade, ultrasound-guided transversus abdominis plane (TAP) block with 0.3% ropivacaine, and postoperative patient-controlled intravenous analgesia (PCIA). The primary and secondary outcomes will be assessed within 24 hours after surgery.",[18],"Drug: Ciprofol",{"label":20,"type":10,"description":21,"interventionNames":22},"Remimazolam Group","Participants in this arm will receive remimazolam, an ultra-short-acting benzodiazepine, for anesthesia induction and maintenance during elective laparoscopic cholecystectomy. All participants will also receive standardized perioperative care, including prophylactic antiemetics (ondansetron 8 mg and dexamethasone 10 mg), intraoperative analgesia with sufentanil and remifentanil, cisatracurium for neuromuscular blockade, ultrasound-guided transversus abdominis plane (TAP) block with 0.3% ropivacaine, and postoperative patient-controlled intravenous analgesia (PCIA). The primary and secondary outcomes will be assessed within 24 hours after surgery.",[23],"Drug: Remimazolam",[25,31,35],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","Propofol","Drug: Propofol (Yangtze River Pharmaceutical Group, Taizhou, Jiangsu, China) Induction: 2 mg\u002Fkg intravenously over ≥ 30 seconds Maintenance: 4-12 mg\u002Fkg\u002Fh by continuous intravenous infusion, titrated to maintain BIS between 40 and 60",[9],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Ciprofol","Drug: Ciprofol (HSK3486; Haisco Pharmaceutical Group, Shenyang, Liaoning, China) Induction: 0.4 mg\u002Fkg intravenously over ≥ 30 seconds Maintenance: 0.8-1.2 mg\u002Fkg\u002Fh by continuous intravenous infusion, titrated to maintain BIS between 40 and 60",[15],{"type":26,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"Remimazolam","Drug: Remimazolam besylate (Yichang Humanwell Pharmaceutical, Yichang, Hubei, China) Induction: 0.3 mg\u002Fkg intravenously over ≥ 1 minute Maintenance: 0.3-1.0 mg\u002Fkg\u002Fh by continuous intravenous infusion, titrated to maintain BIS between 40 and 60",[20],[40],{"name":41,"affiliation":42,"role":43},"Lei Ma, MD, PhD","Second Affiliated Hospital of Xi'an Jiaotong University","PRINCIPAL_INVESTIGATOR",[45,50],{"name":46,"role":47,"phone":48,"phoneExt":30,"email":49},"Liang Zhang, BM","CONTACT","+8613259708740","myselfspace123@126.com",{"name":41,"role":47,"phone":51,"phoneExt":30,"email":52},"+8613519134023","malei0214@xjtu.edu.cn",[54],{"facility":55,"status":56,"city":57,"state":58,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"Xi'an Aerospace Hospital","RECRUITING","Xi'an","Shaanxi","710100","China","CN",{"type":63,"coordinates":64},"Point",[65,66],108.92861,34.25833,{"lat":66,"lon":65},[69,70,74,75],{"name":46,"role":47,"phone":48,"phoneExt":30,"email":49},{"name":71,"role":47,"phone":72,"phoneExt":30,"email":73},"GuoZun He, M.M.","+8617791672110","guozun1004@163.com",{"name":41,"role":43,"phone":30,"phoneExt":30,"email":30},{"name":46,"role":76,"phone":30,"phoneExt":30,"email":30},"SUB_INVESTIGATOR",{"type":78,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100651300","phase-4-a-randomized-controlled-trial-comparing-the-effects-of-different-anesthetic-sedatives-on-ponv-in-laparoscopic-cholecystectomy-100651300",false,"NCT07758803","A Randomized Controlled Trial Comparing the Effects of Different Anesthetic Sedatives on PONV in Laparoscopic Cholecystectomy","A Prospective, Randomized, Controlled, Single-Blind Clinical Trial Comparing the Effects of Propofol, Ciprofol, and Remimazolam on Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* Age 18-80 years, either sex American Society of Anesthesiologists (ASA) physical status classification I-III Scheduled for elective laparoscopic cholecystectomy under general anesthesia Able to understand the study protocol and provide written informed consent Not concurrently enrolled in other clinical studies\n\nExclusion Criteria:\n\n* Known hypersensitivity to any anesthetic agent used in the study Severe cardiac, pulmonary, hepatic, or renal dysfunction Active systemic infectious disease Psychiatric disorder or use of sedative agents within the preceding two weeks Refusal to participate","ALL","18 Years","80 Years",{"count":90,"type":91},114,"ESTIMATED","INTERVENTIONAL",[94],"PHASE4","This study is designed to compare three sedative medications used during general anesthesia for gallbladder removal surgery (laparoscopic cholecystectomy) and their effects on nausea and vomiting after surgery.\n\nBackground Nausea and vomiting after surgery (postoperative nausea and vomiting, PONV) is a common problem, affecting up to 75% of patients undergoing gallbladder surgery. It can cause discomfort, delay recovery, and lead to other complications. Three medications are commonly used to start and maintain anesthesia: propofol, ciprofol, and remimazolam. This study aims to find out which one is associated with the least nausea and vomiting.\n\nStudy Design\n\nThis is a prospective, randomized, controlled, single-blind clinical trial. A total of 114 adult patients scheduled for elective laparoscopic cholecystectomy at Xi'an Aerospace Hospital will be randomly assigned to one of three groups (38 patients each):\n\nPropofol group Ciprofol group Remimazolam group All patients will receive the same anti-nausea prevention and pain control after surgery, regardless of their group.\n\nPrimary Outcome (Main Measure)\n\nThe percentage of patients who experience any nausea and\u002For vomiting within the first 24 hours after surgery.\n\nSecondary Outcomes (Other Measures)\n\nPercentage of patients who experience vomiting within 24 hours after surgery Percentage of patients who experience nausea within 24 hours after surgery Number of nausea, vomiting, and combined PONV episodes within 24 hours Pain level measured on a 0-10 visual analog scale (VAS) at 0, 6, 12, and 24 hours after surgery (0 = no pain, 10 = worst pain imaginable) Highest pain score reported within the first 24 hours after surgery Significance The results will help doctors choose the best sedative medication to reduce nausea and vomiting after gallbladder surgery, especially for patients who are at higher risk, such as women.",[97,98],"Cholelithiasis","Postoperative Nausea and Vomiting",[100,101,102,103,104,105],"postoperative nausea and vomiting","propofol","ciprofol","remimazolam","laparoscopic cholecystectomy","randomized controlled trial","2026-08-17",{"date":108,"type":109},"2026-08-18","ACTUAL",{"date":111,"type":109},"2026-08-15",{"date":113,"type":91},"2026-10-30",{"name":5,"class":6},1]