[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651251":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":53,"collaborators":18,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":57,"sex":63,"minAge":64,"maxAge":18,"enrollmentInfo":65,"targetDuration":18,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":18,"overallStatus":76,"whyStopped":18,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Ottawa Heart Institute Research Corporation","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Immediate Renal Replacement Therapy","EXPERIMENTAL","Participants receive renal replacement therapy within 2-6 hours of randomization.",[13],"Drug: Immediate renal replacement therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard Medical Treatment","NO_INTERVENTION","Participants will receive the standard of care medical therapy with discouragement of renal replacement therapy unless medically necessary.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DRUG","Immediate renal replacement therapy","Renal replacement therapy started within 6 hours of randomization",[9],[26],{"name":27,"affiliation":5,"role":28},"Simon Parlow, MD, FRCPC","PRINCIPAL_INVESTIGATOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},"Hannah Feagan, RN","CONTACT","613-696-7000","hfeagan@ottawaheart.ca",[36],{"facility":37,"status":18,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"University of Ottawa Heart Institute","Ottawa","Ontario","K1Y 4W7","Canada","CA",{"type":44,"coordinates":45},"Point",[46,47],-75.69812,45.41117,{"lat":47,"lon":46},[50,51],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},{"name":52,"role":28,"phone":18,"phoneExt":18,"email":18},"Simon Parlow, MD FRCPC",{"type":54,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100651251","phase-4-capital-offload-shock-100651251",false,"NCT07756801","CAPITAL OFFLOAD-SHOCK","Optimal Timing of Renal Replacement Therapy in Hypervolemic Cardiogenic Shock","OFFLOAD-SHOCK","Inclusion Criteria:\n\n* adult patients \\>\u002F= 18 years of age admitted to an intensive care unit\n* Diagnosed clinically with Society for Cardiovascular Angiography and Interventions (SCAI) Class C or D cardiogenic shock\n* Clinical or hemodynamic evidence of volume overload\n\nExclusion Criteria:\n\n* Patients whose care plan, as determined by the treating clinical team, will not include renal replacement therapy\n* Decision has already been made by the treating clinical team to initiate renal replacement therapy\n* Hyperkalemia with serum potassium \\>\u002F= 6mmol\u002FL at the time of screening\n* Severe metabolic acidosis with serum bicarbonate \\\u003C\u002F= 12 mmol\u002FL at the time of screening\n* Severe azotemia with serum urea \\>\u002F= 40 mmol\u002FL at the time of screening\n* Acute intoxication necessitating use of renal replacement therapy\n* Recent renal replacement therapy (within 30 days)\n* Known end-stage renal disease (defined as an estimated glomerular filtration rate \\\u003C15 ml\u002Fmin\u002F1.73m2\n* presentation with out-of-hospital cardiac arrest","ALL","18 Years",{"count":66,"type":67},456,"ESTIMATED","INTERVENTIONAL",[70],"PHASE4","CAPITAL OFFLOAD-SHOCK will aim to answer if early use of renal replacement therapy, like dialysis, in patients with reduced body fluids causing the heart to be unable to pump enough blood through the body reduces in-hospital death when compared to the current standard of care. The current standard of care is to wait until renal replacement therapy is clinically necessary.",[73,74,75],"Hypervolemia","Cardiogenic Shock","Renal Replacement Therapy","NOT_YET_RECRUITING","2026-08-06",{"date":79,"type":80},"2026-08-11","ACTUAL",{"date":82,"type":67},"2026-09-01",{"date":84,"type":67},"2031-09",{"name":5,"class":6},1]