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Bergthold, MD",{"name":660,"role":100,"phone":53,"phoneExt":53,"email":53},"John Nguyen, MD",{"name":662,"role":100,"phone":53,"phoneExt":53,"email":53},"Anantha Jujjuri, PA",{"name":664,"role":100,"phone":53,"phoneExt":53,"email":53},"Amal Habib Mohamed Jawad Ali Al Yusuf, MD",{"facility":666,"status":62,"city":667,"state":668,"zip":669,"country":66,"countryCode":67,"cosmosGeoPoint":670,"geoPoint":674,"contacts":675},"University of Pennsylvania","Philadelphia","Pennsylvania","19107",{"type":69,"coordinates":671},[672,673],-75.16362,39.95238,{"lat":673,"lon":672},[676,680,684],{"name":677,"role":51,"phone":678,"phoneExt":53,"email":679},"Gina Siermine","215-829-5159","Gina.Siermine@PennMedicine.upenn.edu",{"name":681,"role":51,"phone":682,"phoneExt":53,"email":683},"Allie Oliver","215-829-7104","Alexandria.Oliver@pennmedicine.upenn.edu",{"name":685,"role":47,"phone":53,"phoneExt":53,"email":53},"Eric Kaiser, MD",{"facility":687,"status":62,"city":688,"state":689,"zip":690,"country":66,"countryCode":67,"cosmosGeoPoint":691,"geoPoint":695,"contacts":696},"Brown University Health","Providence","Rhode Island","02903",{"type":69,"coordinates":692},[693,694],-71.41283,41.82399,{"lat":694,"lon":693},[697,701,705],{"name":698,"role":51,"phone":699,"phoneExt":53,"email":700},"Deepica Chaudhary","401-606-4655","DChaudhary@brownhealth.org",{"name":702,"role":51,"phone":703,"phoneExt":53,"email":704},"Alexis DeMarco","401-606-4651","ADemarco@brownhealth.org",{"name":706,"role":47,"phone":53,"phoneExt":53,"email":53},"Roderick Spears, MD",{"facility":708,"status":62,"city":709,"state":710,"zip":711,"country":66,"countryCode":67,"cosmosGeoPoint":712,"geoPoint":716,"contacts":717},"Vanderbilt Medical Center","Nashville","Tennessee","37215",{"type":69,"coordinates":713},[714,715],-86.78444,36.16589,{"lat":715,"lon":714},[718,722,724],{"name":719,"role":51,"phone":720,"phoneExt":53,"email":721},"Jordon Winn","615-421-6094","Jordon.winn@vumc.org",{"name":723,"role":47,"phone":53,"phoneExt":53,"email":53},"Joy Derwenskus, MD",{"name":725,"role":100,"phone":53,"phoneExt":53,"email":53},"Francesca Bagnato, MS",{"facility":727,"status":62,"city":728,"state":729,"zip":730,"country":66,"countryCode":67,"cosmosGeoPoint":731,"geoPoint":735,"contacts":736},"DHR Health Headache Center","McAllen","Texas","78504",{"type":69,"coordinates":732},[733,734],-98.23001,26.20341,{"lat":734,"lon":733},[737,741,744],{"name":738,"role":51,"phone":739,"phoneExt":53,"email":740},"Leah Picazo","956-362-2234","Leah.Picazo@dhrhealth.com",{"name":742,"role":51,"phone":53,"phoneExt":53,"email":743},"Alexis Valencia","Alexis.Valencia@dhrhealth.com",{"name":745,"role":47,"phone":53,"phoneExt":53,"email":53},"Gloria Simms, MD",{"facility":747,"status":62,"city":748,"state":749,"zip":750,"country":66,"countryCode":67,"cosmosGeoPoint":751,"geoPoint":755,"contacts":756},"Advanced Research Institute Ogden","Ogden","Utah","84405",{"type":69,"coordinates":752},[753,754],-111.97383,41.223,{"lat":754,"lon":753},[757,761,764,766,768,770,772,774,776],{"name":758,"role":51,"phone":759,"phoneExt":53,"email":760},"Stephanie Church","801-409-2040","stephanie@advresearch.org",{"name":762,"role":51,"phone":759,"phoneExt":53,"email":763},"Noah Nielsen","noah@advresearch.org",{"name":765,"role":47,"phone":53,"phoneExt":53,"email":53},"Michael Woolman, MD",{"name":767,"role":100,"phone":53,"phoneExt":53,"email":53},"Jonathan N Winkfield, PA-C",{"name":769,"role":100,"phone":53,"phoneExt":53,"email":53},"Abbey Coburn, PA-C",{"name":771,"role":100,"phone":53,"phoneExt":53,"email":53},"Khaldoun M Al-Rayess, MD",{"name":773,"role":100,"phone":53,"phoneExt":53,"email":53},"Christopher L. Davis, DO",{"name":775,"role":100,"phone":53,"phoneExt":53,"email":53},"Lynae C Sorensen, MSN AP FNP-C",{"name":777,"role":100,"phone":53,"phoneExt":53,"email":53},"Michael D DeLange, MD",{"facility":779,"status":62,"city":780,"state":781,"zip":782,"country":66,"countryCode":67,"cosmosGeoPoint":783,"geoPoint":787,"contacts":788},"West Virginia University","Morgantown","West Virginia","26506",{"type":69,"coordinates":784},[785,786],-79.9559,39.62953,{"lat":786,"lon":785},[789,794,797,799,801,803,805],{"name":790,"role":51,"phone":791,"phoneExt":792,"email":793},"Lauren Chase RN, BSN","304-598-4000","79418","lauren.chase@wvumedicine.org",{"name":795,"role":51,"phone":53,"phoneExt":53,"email":796},"Bethany Moore, RPh","Bethany.moore2@wvumedicine.org",{"name":798,"role":47,"phone":53,"phoneExt":53,"email":53},"Kristina Lopez, MD",{"name":800,"role":100,"phone":53,"phoneExt":53,"email":53},"David Watson, MD",{"name":802,"role":100,"phone":53,"phoneExt":53,"email":53},"Tiffany Lannan, FNP-BC",{"name":804,"role":100,"phone":53,"phoneExt":53,"email":53},"Heather Hickman, FNP-BC",{"name":806,"role":100,"phone":53,"phoneExt":53,"email":53},"Lindsey S Keczan, FNP-BC",{"facility":808,"status":62,"city":809,"state":810,"zip":811,"country":66,"countryCode":67,"cosmosGeoPoint":812,"geoPoint":816,"contacts":817},"Marshfield Clinic Research Institute","Marshfield","Wisconsin","54449",{"type":69,"coordinates":813},[814,815],-90.1718,44.66885,{"lat":815,"lon":814},[818,822,826,828],{"name":819,"role":51,"phone":820,"phoneExt":53,"email":821},"Megan Johnson","715-389-5473","johnson.megan.a@marshfieldresearch.org",{"name":823,"role":51,"phone":824,"phoneExt":53,"email":825},"Stacy Welter","715-221-6492","welter.stacy@marshfieldresearch.org",{"name":827,"role":47,"phone":53,"phoneExt":53,"email":53},"Jeff VanWormer, PhD",{"name":829,"role":100,"phone":53,"phoneExt":53,"email":53},"Lee Cody, MD",{"facility":831,"status":62,"city":832,"state":810,"zip":833,"country":66,"countryCode":67,"cosmosGeoPoint":834,"geoPoint":838,"contacts":839},"The Medical College of Wisconsin","Milwaukee","53226",{"type":69,"coordinates":835},[836,837],-87.90647,43.0389,{"lat":837,"lon":836},[840,844,848,850],{"name":841,"role":51,"phone":842,"phoneExt":53,"email":843},"Karen Schmidt, RN","(414) 955-0674","kaschmidt@mcw.edu",{"name":845,"role":51,"phone":846,"phoneExt":53,"email":847},"Victoria Ochotnicky","(414) 955-0659","vochotnicky@mcw.edu",{"name":849,"role":47,"phone":53,"phoneExt":53,"email":53},"Glen Soloman, MD",{"name":851,"role":100,"phone":53,"phoneExt":53,"email":53},"James Murtha, MD",{"type":47,"investigatorFullName":853,"investigatorTitle":854,"investigatorAffiliation":5,"oldNameTitle":53,"oldOrganization":53},"Todd J. Schwedt","Principal Investigator",[856,858,860],{"name":857,"class":6},"University of Iowa",{"name":859,"class":6},"Patient-Centered Outcomes Research Institute",{"name":861,"class":862},"AbbVie","INDUSTRY","100590794","phase-4-comparative-effectiveness-of-migraine-preventive-medications-the-apt-comparison-study-100590794",false,"NCT06972056","Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study","A Comparative Effectiveness Study of Oral Medications Used for Migraine Prevention: The APT Comparison Study","Inclusion Criteria:\n\n* Adults, 18-70 years of age at the time of enrollment\n* Migraine with aura, migraine without aura, and\u002For chronic migraine; according to ICHD-3 diagnostic criteria. (Those with daily or continuous headaches are not excluded.)\n* Migraine onset prior to 50 years of age\n* Migraine present for at least 12 months at the time of enrollment\n* At least four \"moderate to severe headache days\" per month (by patient self-report and then confirmed during four-week pre-randomization headache diary phase) A \"moderate to severe headache day\" is defined as a day during which there is a headache of moderate to severe intensity that lasts for at least four hours, or a day on which a migraine-specific acute medication is taken to treat headache.\n* If already taking a migraine preventive treatment, willing to continue with that treatment without dose change during the first 16 weeks of the study, including the 4-week run-in phase and 12-week randomized phase.\n* Not pregnant or breastfeeding\n* Women of childbearing potential must agree to use effective methods of contraception to reduce the risk of pregnancy.\n* Willingness and ability to provide informed consent.\n* Willingness and ability to complete all research visits.\n\nExclusion Criteria:\n\n* Contraindications to taking atogepant, propranolol, or topiramate.\n* Currently taking atogepant, propranolol, or topiramate\\*\n* Previously took atogepant, propranolol, or topiramate\\*\n* Unwillingness to take atogepant, topiramate, or propranolol.\n* Current use of a CGRP-targeting preventive medication or beta-blocker\n* Migraine with brainstem aura\n* Hemiplegic migraine\n* Retinal migraine\n* Migraine aura without headache (exclusively)\n* Pure menstrual migraine\n* Trigeminal autonomic cephalalgias\n* Facial neuralgias\n* Secondary headache disorders (medication overuse headache is not an exclusion)\n* Migraine preventive treatment has been started or dose has been changed within 12 weeks prior to potential enrollment.\n* Used opioids or butalbital on five or more days per month on average for at least 3 months prior to enrollment.\n* Current or past epilepsy\n* Severe hepatic impairment\n* Moderate or more severe renal impairment \\* Occasional as needed use of propranolol, currently or in the past, is not an exclusion, such as taking as needed propranolol for treatment of anxiety.","ALL","18 Years","70 Years",{"count":874,"type":875},1335,"ESTIMATED","INTERVENTIONAL",[878],"PHASE4","This goal of this study is to compare three medications used for migraine preventive treatment.\n\nThis study will compare atogepant, a newer migraine preventive medication, with two older preventive medications, topiramate and propranolol. It will be determined if one works better and is more tolerable than the others.\n\nResearch participants will:\n\n* Be randomly assigned to one of the three medications.\n* Provide information about their migraine pattern using a daily headache diary and during research visits.",[881],"Migraine",[881,883,884],"Migraine with aura","Migraine prevention","2026-07-29",{"date":887,"type":888},"2026-07-30","ACTUAL",{"date":890,"type":888},"2025-07-09",{"date":892,"type":875},"2029-12-01",{"name":5,"class":6},36]