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Clinical failure: Absence of resolution of clinical signs and symptoms of S. aureus bacteremia such that no additional antibiotic therapy is required or anticipated.\n2. Infectious Complications: Including new endocarditis; new evidence of other deep metastatic foci (e.g., osteomyelitis or deep abscess); relapse of MRSA bacteremia after a patient has sterilized their initial blood cultures; readmission for subsequent care of S. aureus bacteremia; need for unplanned source control procedures; change of therapy due to inadequate clinical response.\n3. Serious adverse drug event (Common Terminology Criteria class 4) due to study drug OR adverse drug event (classes 1-3) leading to discontinuation of the study drug","Day 90 post enrollment in the S. aureus Network Adaptive Platform Trial (NCT05137119)",[14,17,20,23,26,30],{"measure":15,"description":16,"timeFrame":12},"Clinical failure","Defined as the absence of resolution of clinical signs and symptoms of S. aureus bacteremia such that no additional antibiotic therapy is required or anticipated for its treatment.",{"measure":18,"description":19,"timeFrame":12},"Serious Adverse Event or Adverse Event Leading to Discontinuation","Defined as a serious adverse drug event (Common Terminology Criteria for Adverse Events (CTCAE) class 4) presumed due to study drug OR adverse drug event (CTCAE classes 1-3) leading to discontinuation of the study drug",{"measure":21,"description":22,"timeFrame":12},"All cause mortality","Death from any 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Hospital","Edmonton","Alberta","Canada","CA",{"type":84,"coordinates":260},[261,262],-113.46871,53.55014,{"lat":262,"lon":261},[265,268],{"name":266,"role":70,"phone":33,"phoneExt":33,"email":267},"Stephanie Smith, MD","ss@ualberta.ca",{"name":266,"role":66,"phone":33,"phoneExt":33,"email":33},{"facility":270,"status":77,"city":271,"state":272,"zip":273,"country":257,"countryCode":258,"cosmosGeoPoint":274,"geoPoint":278,"contacts":279},"Fraser Health Authority (Surrey Memorial Hospital)","Surrey","British Columbia","V3V1Z2",{"type":84,"coordinates":275},[276,277],-122.82509,49.10635,{"lat":277,"lon":276},[280,283],{"name":281,"role":70,"phone":33,"phoneExt":33,"email":282},"Christopher Condin, PhD","christopher.condin@fraserhealth.ca",{"name":284,"role":66,"phone":33,"phoneExt":33,"email":33},"Kevin Afra, MD",{"facility":286,"status":77,"city":287,"state":288,"zip":33,"country":257,"countryCode":258,"cosmosGeoPoint":289,"geoPoint":293,"contacts":294},"Newfoundland Health Services (Health Sciences Centre and St. Clare's Mercy Hospital)","St. John's","Newfoundland and Labrador",{"type":84,"coordinates":290},[291,292],-52.70931,47.56494,{"lat":292,"lon":291},[295,298],{"name":296,"role":70,"phone":33,"phoneExt":33,"email":297},"Peter Daly, MD","pkd336@mun.ca",{"name":296,"role":66,"phone":33,"phoneExt":33,"email":33},{"facility":300,"status":77,"city":301,"state":302,"zip":303,"country":257,"countryCode":258,"cosmosGeoPoint":304,"geoPoint":308,"contacts":309},"Hamilton Health Sciences (Hamilton General Hospital and Juravinski Hospital)","Hamilton","Ontario","L8L 2X2",{"type":84,"coordinates":305},[306,307],-79.84963,43.25011,{"lat":307,"lon":306},[310,315],{"name":311,"role":70,"phone":312,"phoneExt":313,"email":314},"Dominik Mertz, 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Lee MD MPH FIDSA","Associate Professor of Medicine",[382,384],{"name":383,"class":6},"University of Melbourne",{"name":385,"class":6},"The Peter Doherty Institute for Infection and Immunity","100565065","phase-4-daptomycin-vs-vancomycin-for-the-treatment-of-methicillin-resistant-s-aureus-bacteremia-100565065",false,"NCT06637332","Daptomycin vs. Vancomycin for the Treatment of Methicillin Resistant S. Aureus Bacteremia","DAPTO-SNAP: Daptomycin vs. Vancomycin for the Treatment of Methicillin Resistant S. Aureus Bacteremia","DAPTO-SNAP","The participant must meet all inclusion and exclusion criteria for the SNAP Platform (NCT05137119) and also the following inclusion and exclusion criteria:\n\nInclusion Criteria:\n\n* Methicillin-resistant S. aureus bacteremia\n\nExclusion Criteria:\n\n* Severe allergy or non-severe rash to vancomycin or daptomycin\n* Suspected or confirmed MRSA pneumonia\n* Known vancomycin minimum inhibitory concentration (MIC) greater than or equal to 2mg\u002FL or daptomycin MIC greater than or equal to 1mg\u002FL","ALL","18 Years",{"count":397,"type":398},300,"ESTIMATED","INTERVENTIONAL",[401],"PHASE4","This is an open label randomized controlled trial for patients with methicillin resistant S. aureus (MRSA) bloodstream infection which will directly compare the two most commonly used therapies, vancomycin and daptomycin.\n\nThis study is an approved sub-study of The Staphylococcus aureus Network Adaptive Platform (SNAP) trial (NCT05137119)",[404,405,406,407,408],"Staphylococcus Aureus Septicemia","Staphylococcus Aureus Bacteremia","S. Aureus Bacteremia","S. Aureus Bloodstream Infection","Staphylococcus Aureus Endocarditis",[410,411,412,413,42,48],"S. aureus bacteremia","Methicllin resistant","MRSA","S. aureus bloodstream infection","2026-09-08",{"date":416,"type":417},"2026-09-09","ACTUAL",{"date":419,"type":417},"2024-11-14",{"date":421,"type":398},"2029-11",{"name":379,"class":6},20]