[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646557":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":30,"locations":26,"responsibleParty":40,"collaborators":26,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":26,"eligibilityCriteria":50,"healthyVolunteers":46,"sex":51,"minAge":52,"maxAge":26,"enrollmentInfo":53,"targetDuration":26,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":67,"whyStopped":26,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":26},{"fullName":5,"class":6},"Oregon Health and Science University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Extended Oral TXA","EXPERIMENTAL","Participants will receive standard 1.95mg pre-operative oral TXA dose in addition to 1.95mg oral TXA on post-operative days 1, 2, and 3.",[13],"Drug: Extended oral tranexamic acid regimen",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Patients will receive standard pre-operative 1.95mg oral TXA, followed by a placebo pill on post-operative days 1, 2 and 3.",[19],"Drug: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Extended oral tranexamic acid regimen","Participants in the intervention group will receive 1.95mg of oral tranexamic acid on post-operative day 1, 2, and 3.",[9],null,{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":26},"Patients will receive an oral placebo medication on post-operative day 1, 2, and 3.",[15],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":26,"email":35},"Ryland Kagan, MD","CONTACT","503 494-6400","kagan@ohsu.edu",{"name":37,"role":33,"phone":38,"phoneExt":26,"email":39},"Madison Hayes-Lattin, MD","503) 494-6400","hayeslam@ohsu.edu",{"type":41,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Ryland Kagan","Associate Professor of Orthopaedics and Rehabilitation","100646557","phase-4-extended-post-operative-oral-txa-in-primary-tha-100646557",false,"NCT07685743","Extended Post-operative Oral TXA in Primary THA","Extended Post-operative Oral TXA vs.Standard Perioperative TXA in Primary TJA: A Randomized, Double-Blind, Placebo-Controlled Trial","Inclusion Criteria:\n\n* Age ≥18 years\n* Undergoing primary total knee arthroplasty (TKA) or total hip arthroplasty (THA) for osteoarthritis\n* Ability to provide written informed consent\n* Willingness to comply with study protocol\n\nExclusion Criteria:\n\n* History of venous thromboembolism (DVT or PE)\n* Active malignancy\n* Allergy or contraindication to tranexamic acid (TXA)\n* Post-operative anticoagulation therapy other than aspirin\n* History of color blindness or retinal disease","ALL","18 Years",{"count":54,"type":55},170,"ESTIMATED","INTERVENTIONAL",[58],"PHASE4","The goal of this clinical trial is to learn if extended post-operative oral tranexamic acid (TXA) - a medication that reduces bleeding by slowing the breakdown of blood clots - can improve functional recovery following surgery in adults undergoing primary total knee or hip arthroplasty for osteoarthritis. The main question it aims to answer is: Does extended post-operative oral TXA improve functional outcomes at 6 weeks post-operatively compared to standard perioperative TXA alone? Researchers will compare patients receiving extended oral TXA to patients receiving matching placebo capsules on the same schedule to see if the extended TXA regimen reduces blood loss, improves early functional outcomes, and reduces pain without increasing complication rates. Participants will receive standard perioperative oral TXA (1.95 g) prior to surgical incision, along with standard VTE prophylaxis. They will be randomly assigned to receive either oral TXA or matching placebo capsules once daily on post-operative days 1, 2, and 3. Participants will attend follow-up visits at 2, 6, and 12 weeks post-operatively to complete functional outcome questionnaires, pain assessments, and - for knee replacement patients - range of motion measurements.",[61,62],"Osteoarthritis (OA) of the Hip","Osteoarthritis (OA) of the Knee",[64,65,66],"Tranexamic acid","Patient Reported Outcomes","Arthroplasty","NOT_YET_RECRUITING","2026-07-06",{"date":70,"type":71},"2026-07-08","ACTUAL",{"date":73,"type":55},"2026-09-01",{"date":75,"type":55},"2028-09-01",{"name":5,"class":6}]