[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632745":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":11,"locations":27,"responsibleParty":47,"collaborators":11,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":11,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":11,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":29,"whyStopped":11,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"University of Kentucky","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Methadone","EXPERIMENTAL",null,[13],"Drug: Methadone",{"label":15,"type":16,"description":11,"interventionNames":17},"Standard of care","ACTIVE_COMPARATOR",[18],"Drug: Standard of care",[20,24],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":11},"DRUG","Methadone 0.2 mg\u002Fkg (max 20 mg)",[9],{"type":21,"name":15,"description":25,"armGroupLabels":26,"otherNames":11},"Standard intraoperative opioid regimen (control)",[15],[28],{"facility":5,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"RECRUITING","Lexington","Kentucky","40536","United States","US",{"type":36,"coordinates":37},"Point",[38,39],-84.47772,37.98869,{"lat":39,"lon":38},[42],{"name":43,"role":44,"phone":45,"phoneExt":11,"email":46},"Brandon Knopp, MD","CONTACT","859-218-0097","bwkn222@uky.edu",{"type":48,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"SPONSOR_INVESTIGATOR","Brandon Knopp","Principal Investigator","100632745","phase-4-methadone-for-post-operative-spine-surgery-100632745",false,"NCT07517679","Methadone for Post-operative Spine Surgery","Effect of Post-Induction Methadone on Postoperative Pain, Opioid Use, and Recovery in Spine Surgery","Inclusion Criteria:\n\n* Undergoing elective spine surgery (e.g., fusion, decompression)\n* Expected postoperative inpatient admission\n* Able to provide informed consent\n* Patients with opioid use disorder (OUD) may be included if on stable maintenance therapy\n\nExclusion Criteria:\n\n* Use of regional or neuraxial anesthesia\n* Contraindication to methadone use (e.g., prolonged QTc, allergy, severe hepatic disease)\n* Cognitive impairment precluding consent or accurate pain scoring","ALL","18 Years","120 Years",{"count":62,"type":63},30,"ESTIMATED","INTERVENTIONAL",[66],"PHASE4","The goal of this prospective cohort study is to evaluate the clinical effects of post-induction methadone on perioperative pain control, opioid requirements, and recovery outcomes in adult patients undergoing elective spine surgery, with the goal of improving postoperative analgesia and enhancing recovery efficiency. The main questions it aims to answer are the perioperative pain control and opioid requirements between the two groups.\n\nPost-induction methadone can offer equivalent or improved pain control following major spine procedures and reduce intra- and postoperative opioid requirements, improve perioperative pain control and shorten PACU stay.\n\nResearchers will compare perioperative opioid use (morphine equivalents (ME), during the intraoperative and postoperative periods (PACU and 24-hour totals) between the standard intraoperative opioid regimen group and the methadone group.\n\nPatients will be randomized preoperatively to one of two groups: (both groups will receive additional multimodal pain control including opioids, not including methadone, as needed) Standard intraoperative opioid regimen (control) Methadone 0.2 mg\u002Fkg (max 20 mg)\n\nIf the patient is in the methadone group, the patient will receive a predetermined dose of Methadone (0.2mg\u002Fkg) intravenously after induction (they are given medications to sleep for surgery). They will proceed with surgery, and all patients will receive standard of care management regardless of whether they receive Methadone or not. Following the surgery, all study participants will be asked at set times about their pain level and, 24 hours after the surgery, will be asked if they are satisfied with their pain management for the surgery. Data regarding their clinical progression and pain control\u002Fpain medication requirements will be collected for the duration of the hospitalization.",[69],"Pain, Postoperative",[71,72,73],"methadone","opioids","spine surgery","2026-07-17",{"date":76,"type":77},"2026-07-20","ACTUAL",{"date":79,"type":77},"2026-06-10",{"date":81,"type":63},"2027-04",{"name":49,"class":6},1]