[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100598788":3},{"organization":4,"outcomesModule":7,"designInfo":23,"detailedDescription":26,"studyPopulation":26,"armGroups":30,"interventions":43,"overallOfficials":51,"centralContacts":56,"locations":62,"responsibleParty":80,"collaborators":83,"id":90,"slug":91,"hasResults":92,"nctId":93,"briefTitle":94,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":97,"sex":98,"minAge":99,"maxAge":100,"enrollmentInfo":101,"targetDuration":26,"studyType":104,"phases":105,"briefSummary":107,"conditions":108,"keywords":110,"overallStatus":65,"whyStopped":26,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":18},[9],{"measure":10,"description":11,"timeFrame":12},"PrEP initiation","Women who start to use PrEP","From enrolment to 6 months",[14],{"measure":15,"description":16,"timeFrame":17},"PrEP persistence at 3 months","Women who continue to use PrEP 3 months since they initiated PrEP","From enrolment to 3 months",[19],{"measure":20,"description":21,"timeFrame":22},"PrEP persistence at 6 months","Women who continue to use PrEP 6 months since they initiated PrEP","Enrolment to 6 months",{"allocation":24,"interventionModel":25,"interventionModelDescription":26,"primaryPurpose":27,"observationalModel":26,"timePerspective":26,"maskingInfo":28},"RANDOMIZED","SINGLE_GROUP",null,"PREVENTION",{"masking":29,"maskingDescription":26,"whoMasked":26},"NONE",[31,37],{"label":32,"type":33,"description":34,"interventionNames":35},"Routine PrEP Program","ACTIVE_COMPARATOR","In the active comparator, clinics will offer the standard of care PrEP Program, which includes daily oral PrEP for young women.",[36],"Drug: Routine Oral PrEP",{"label":38,"type":39,"description":40,"interventionNames":41},"Multiple Product PrEP Program","EXPERIMENTAL","In the intervention phase, clinics will offer a multi-product PrEP program, which includes daily oral PrEP and other forms of PrEP that are available. To start, the dapivirine vaginal ring will be included among the other forms of PrEP that are available. Others will be added as they become available in Kenya.",[42,36],"Drug: Multiple Product PrEP Program",[44,47],{"type":45,"name":38,"description":40,"armGroupLabels":46,"otherNames":26},"DRUG",[38],{"type":45,"name":48,"description":49,"armGroupLabels":50,"otherNames":26},"Routine Oral PrEP","Daily oral PrEP",[38,32],[52],{"name":53,"affiliation":54,"role":55},"Nelly Mugo, MBChB, MMed, MPH","Kenya Medical Research Institute","PRINCIPAL_INVESTIGATOR",[57],{"name":58,"role":59,"phone":60,"phoneExt":26,"email":61},"Renee Heffron, PhD, MPH","CONTACT","205-934-7349","rheffron@uabmc.edu",[63],{"facility":64,"status":65,"city":66,"state":67,"zip":26,"country":68,"countryCode":69,"cosmosGeoPoint":26,"geoPoint":26,"contacts":70},"Kenya Medical Research Institute and Partners in Health & Research Development","RECRUITING","Thika","Kiambu County","Kenya","KE",[71,73,75,78],{"name":72,"role":59,"phone":26,"phoneExt":26,"email":26},"Nelly Mugo, MBChB, MPH",{"name":74,"role":55,"phone":26,"phoneExt":26,"email":26},"Nelly Mugo, MBChB",{"name":76,"role":77,"phone":26,"phoneExt":26,"email":26},"Catherine Kiptinness, MPH","SUB_INVESTIGATOR",{"name":79,"role":77,"phone":26,"phoneExt":26,"email":26},"Kenneth Ngure, PhD",{"type":55,"investigatorFullName":81,"investigatorTitle":82,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Renee Heffron","Professor",[84,86,87],{"name":85,"class":6},"University of Washington",{"name":54,"class":6},{"name":88,"class":89},"National Institute of Mental Health (NIMH)","NIH","100598788","phase-4-multi-product-prep-delivery-to-young-women-seeking-reproductive-health-services-and-coverage-of-hiv-prevention-100598788",false,"NCT07076043","Multi-product PrEP Delivery to Young Women Seeking Reproductive Health Services and Coverage of HIV Prevention","PrEMIA","Inclusion Criteria for Adolescent Girls and Young Women seeking reproductive health services:\n\nAge ≥18 years and ≤30years. Seeking a reproductive health service from one of the project facilities (reproductive health services include but are not limited to family planning, maternal and child health, postnatal care).\n\nAGYW receiving reproductive health-related services through OPD, or other departments are eligible. AGYW receiving reproductive health-related services through other departments are eligible.\n\nWilling and able to partake in an informed consent process. Able to speak and read in Kiswahili or English.",true,"FEMALE","18 Years","30 Years",{"count":102,"type":103},1400,"ESTIMATED","INTERVENTIONAL",[106],"PHASE4","Following on the heels of large implementation science projects that participated in the launch of widespread daily oral PrEP availability, investigators will launch and study the integration of novel PrEP products - beginning with the dapivirine ring- into existing PrEP programs that reach women seeking reproductive health care at health facilities in Kenya. Intervention delivery will be launched among 12 participating clinics with approximately 1400 AGYW seeking reproductive health services and counseled about PrEP through a stepped wedge cluster randomized trial. investigators will support participating clinics to add dapivirine ring into their existing PrEP services offered to women seeking reproductive health care. The primary aim of the study will be to determine whether the availability of multiple PrEP products to young women will result in greater frequency of PrEP initiation and persistence.",[109],"Hiv",[111,112,113,68,114],"HIV prevention","PrEP","Adolescent girls and young women","stepped wedge cluster randomized trial","2026-07-20",{"date":117,"type":118},"2026-07-22","ACTUAL",{"date":120,"type":118},"2025-06-03",{"date":122,"type":103},"2029-12-30",{"name":5,"class":6},1]