[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100609979":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":59,"collaborators":26,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":64,"sex":70,"minAge":71,"maxAge":26,"enrollmentInfo":72,"targetDuration":26,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":26,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intravenous methadone intraoperatively","ACTIVE_COMPARATOR","Subjects in the IV methadone arm will receive methadone intravenously during cardiac surgery",[13],"Drug: Methadone, intravenously",{"label":15,"type":16,"description":17,"interventionNames":18},"Oral methadone, immediately prior to transport","EXPERIMENTAL","Subjects in the oral methadone arm will receive methadone orally prior to cardiac surgery",[19],"Drug: Methadone, oral",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Methadone, oral","Patients will receive 0.4mg\u002Fkg PO methadone immediately prior to transport to the operating room",[15],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Methadone, intravenously","Patients will receive 0.3mg\u002Fkg methadone intravenously after induction of general anesthesia",[9],[32],{"name":33,"affiliation":5,"role":34},"Krishnan Ramanujan, M.D.","PRINCIPAL_INVESTIGATOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Anesthesia Clinical Research Unit","CONTACT","866-265-9263","Paul.Johar@mayo.edu",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Mayo Clinic in Rochester","RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-92.4699,44.02163,{"lat":54,"lon":53},[57,58],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":26},{"name":33,"role":34,"phone":26,"phoneExt":26,"email":26},{"type":34,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Krishnan Ramanujan","Principal Investigator","100609979","phase-4-oral-methadone-in-cardiac-surgery-100609979",false,"NCT07221617","Oral Methadone in Cardiac Surgery","Oral Methadone In Cardiac Surgery","OMICS","Inclusion Criteria:\n\n• Undergoing elective cardiac surgery\n\nExclusion Criteria:\n\n* Chronic pain requiring opioid medications as an outpatient\n* Opioid use disorder on medication assistance treatment\n* Prolonged QTc \\>500ms\n* Chronic kidney disease with eGFR \\\u003C 30mL\u002Fmin\n* Documented cirrhosis\n* Intolerance to methadone\n* Admitted inpatient in an intensive care unit (ICU) immediately prior to surgery\n* Pregnancy at the time of surgery\n* Subsequent surgeries after index surgery","ALL","18 Years",{"count":73,"type":74},100,"ESTIMATED","INTERVENTIONAL",[77],"PHASE4","The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone upon induction of general anesthesia on postoperative pain for patients undergoing elective cardiac surgery.",[80,81,82],"Pain, Postoperative","Anesthesia","Cardiac Surgery","2026-08-20",{"date":85,"type":86},"2026-08-21","ACTUAL",{"date":88,"type":86},"2026-01-13",{"date":90,"type":74},"2026-08-31",{"name":5,"class":6},1]