[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650424":3},{"organization":4,"outcomesModule":7,"designInfo":126,"detailedDescription":132,"studyPopulation":125,"armGroups":133,"interventions":139,"overallOfficials":125,"centralContacts":145,"locations":151,"responsibleParty":1022,"collaborators":1024,"id":1027,"slug":1028,"hasResults":1029,"nctId":1030,"briefTitle":1031,"officialTitle":1032,"acronym":125,"eligibilityCriteria":1033,"healthyVolunteers":1029,"sex":1034,"minAge":125,"maxAge":125,"enrollmentInfo":1035,"targetDuration":125,"studyType":1038,"phases":1039,"briefSummary":1041,"conditions":1042,"keywords":1045,"overallStatus":594,"whyStopped":125,"lastUpdateSubmitDate":1052,"lastUpdatePostDateStruct":1053,"startDateStruct":1056,"completionDateStruct":1058,"leadSponsor":1060,"locationsCount":1061},{"fullName":5,"class":6},"Swedish Orphan Biovitrum","INDUSTRY",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":125},[9],{"measure":10,"description":11,"timeFrame":12},"Achieving urine protein-to-creatinine ratio (UPCR) of \u003C1 g\u002Fg","To describe the real-world clinical effectiveness of pegcetacoplan in participants with C3G or primary IC-MPGN","at 6 months after starting pegcetacoplan treatment",[14,18,22,25,28,32,35,38,42,45,48,52,55,58,61,65,69,73,77,81,85,89,91,94,97,101,104,107,110,113,116,119,122],{"measure":15,"description":16,"timeFrame":17},"Participant demographics (age, sex, race)","To describe the demographics of participants initiating pegcetacoplan treatment.","Day 1 of treatment\u002FBaseline.",{"measure":19,"description":20,"timeFrame":21},"Clinical characteristics of renal disease (UPCR)","To describe clinical characteristics (UPCR), of renal disease in participants initiating pegcetacoplan treatment.","Prior to and - Day 1 of treatment\u002FBaseline.",{"measure":23,"description":24,"timeFrame":21},"Clinical characteristics of renal disease (eGFR)","To describe clinical characteristics (eGFR), of renal disease in participants initiating pegcetacoplan treatment.",{"measure":26,"description":27,"timeFrame":17},"Prior and concomitant C3G and primary IC-MPGN treatment information","To describe the medication use of participants initiating pegcetacoplan treatment.",{"measure":29,"description":30,"timeFrame":31},"≥50% proteinuria reduction","Cumulative incidence function will be used to describe the time from the start of pegcetacoplan treatment to the first occurrence of ≥50% proteinuria reduction.","At 1, 3, 6, 12 months and then every 6 months through the last dose received during the study, up to 5.5 years.",{"measure":33,"description":34,"timeFrame":31},"\u003C1 g\u002Fg UPCR","Cumulative incidence function will be used to describe the time from the start of pegcetacoplan treatment to the first occurrence of \\\u003C1 g\u002Fg UPCR.",{"measure":36,"description":37,"timeFrame":31},"\u003C0.5 g\u002Fg UPCR among participants aged 18 years or older","Cumulative incidence function will be used to describe the time from the start of pegcetacoplan treatment to the first occurrence of \\\u003C0.5 g\u002Fg UPCR among participants aged 18 years or older.",{"measure":39,"description":40,"timeFrame":41},"\u003C0.2 g\u002Fg UPCR among participants less than 18 years of age","Cumulative incidence function will be used to describe the time from the start of pegcetacoplan treatment to the first occurrence of \\\u003C0.2 g\u002Fg UPCR among participants less than 18 years of age.","Whenever the event occurs for the first time during pegcetacoplan treatment, up to 5.5 years.",{"measure":43,"description":44,"timeFrame":41},"Resolution of nephrotic syndrome in those with nephrotic syndrome","Cumulative incidence function will be used to describe the time from the start of pegcetacoplan treatment to the first occurrence of resolution of nephrotic syndrome in participants with nephrotic syndrome.",{"measure":46,"description":47,"timeFrame":41},"Sustained doubling of serum creatinine","Occurrence of sustained doubling of serum creatinine from baseline.",{"measure":49,"description":50,"timeFrame":51},"Progression to Chronic Kidney Disease Stage 5 or ESRD","Occurrence of Progression to Chronic Kidney Disease Stage 5 or ESRD from baseline.","At occurrence, prior to and during pegcetacoplan treatment, up to 5.5 years.",{"measure":53,"description":54,"timeFrame":51},"Receipt of new kidney transplant","Occurrence of receipt of new kidney transplant from baseline.",{"measure":56,"description":57,"timeFrame":51},"New onset of maintenance dialysis (i.e., for at least 4 weeks)","Occurrence of new onset of maintenance dialysis (i.e., for at least 4 weeks)",{"measure":59,"description":60,"timeFrame":51},"Death from kidney failure","Occurrence of death from kidney failure.",{"measure":62,"description":63,"timeFrame":64},"Change in urine protein-to-creatinine ratio (UPCR) from the most recent diagnostic test results","Occurrence of change in UPCR from the most recent diagnostic test results.","Prior to start of pegcetacoplan treatment, at 1, 3, 6, 12 months, and then every 6 months through the last pegcetacoplan dose or up to 2 years after the enrolment date of the last participant.",{"measure":66,"description":67,"timeFrame":68},"Achieving UPCR of \u003C1 g\u002Fg","Occurrence of UPCR of \\\u003C1 g\u002Fg","At 1, 3, 6, 12 months and then every 6 months through the last pegcetacoplan dose or up to 2 years after the enrolment date of the last participant.",{"measure":70,"description":71,"timeFrame":72},"Change in eGFR derived from the most recent diagnostic test results of creatinine and height (if applicable)","Change in eGFR derived at 1, 3, 6, 12 months and then yearly from the most recent diagnostic test results of creatinine prior to start of pegcetacoplan.","Prior to start of pegcetacoplan treatment to eGFR derived at 1, 3, 6, 12 months and then until the last pegcetacoplan dose or up to 2 years after the enrolment date of the last participant.",{"measure":74,"description":75,"timeFrame":76},"Proportion of participants with annualised eGFR decline ≤5 mL\u002Fmin\u002F1.73 m2","Proportion of participants with annualised eGFR decline ≤5 mL\u002Fmin\u002F1.73 m2 yearly during pegcetacoplan treatment in the study.","Yearly during pegcetacoplan treatment up to the last pegcetacoplan dose or up to 2 years after the enrolment date of the last participant.",{"measure":78,"description":79,"timeFrame":80},"Change in kidney biopsy findings","Kidney biopsy findings through the last dose of pegcetacoplan received during the study.","At occurrence, during pegcetacoplan treatment, through the last pegcetacoplan dose or up to 2 years after the enrolment date of the last participant.",{"measure":82,"description":83,"timeFrame":84},"Summary of pegcetacoplan treatment information","To describe pegcetacoplan dosing schedule and treatment patterns.","Throughout the whole study duration whenever pegcetacoplan is administered per standard of care, up to 5.5 years.",{"measure":86,"description":87,"timeFrame":88},"Exposure-adjusted incidence rate of SAEs","Exposure-adjusted incidence rate of SAEs.","Ongoing from the start of pegcetacoplan treatment to study end, or 8 weeks post last dose of pegcetacoplan, whichever occurs earlier.",{"measure":90,"description":90,"timeFrame":88},"Exposure-adjusted incidence rate of AESIs",{"measure":92,"description":92,"timeFrame":93},"Summary scores of FACIT-Fatigue and WPAI","At the start of pegcetacoplan treatment, as available; at study enrolment; and every 6 months during treatment, through the last pegcetacoplan dose or up to 2 years after the enrolment date of the last participant.",{"measure":95,"description":95,"timeFrame":96},"Summary of TSQM among adult participants","At the start of pegcetacoplan treatment, as available, at study enrolment, and every 6 months during treatment through the last pegcetacoplan dose or up to 2 years after the enrolment date of the last participant.",{"measure":98,"description":99,"timeFrame":100},"Annualised number of C3G and primary IC-MPGN-related inpatient or outpatient hospital visits","Annualised C3G and primary IC-MPGN-related inpatient or outpatient hospital visits before, during and after treatment with pegectacoplan.","Prior to, during treatment and after the last pegcetacoplan dose or up to 2 years after the enrolment date of the last participant.",{"measure":102,"description":103,"timeFrame":100},"Annualised C3G-related length of hospital stays","Annualised C3G-related length of hospital stays before, during and after treatment with pegectacoplan.",{"measure":105,"description":106,"timeFrame":100},"Annualised primary IC-MPGN-related length of hospital stays","Annualised primary IC-MPGN-related length of hospital stays before, during and after pegcetacoplan treatment.",{"measure":108,"description":109,"timeFrame":100},"Annualised number of C3G-related length of ICU admissions","Annualised number of C3G-related ICU admissions before, during and after pegcetacoplan treatment.",{"measure":111,"description":112,"timeFrame":100},"Annualised number of primary IC-MPGN-related ICU admissions","Annualised number of primary IC-MPGN-related ICU admissions before, during and after pegcetacoplan treatment.",{"measure":114,"description":115,"timeFrame":100},"Annualised C3G-related length of ICU stay","Annualised C3G-related length of ICU stay before, during and after pegcetacoplan treatment.",{"measure":117,"description":118,"timeFrame":100},"Annualised primary IC-MPGN-related length of ICU stay","Annualised primary IC-MPGN-related length of ICU stay before, during and after pegcetacoplan treatment.",{"measure":120,"description":121,"timeFrame":100},"Annualised number of C3G-related emergency department visits","Annualised number of C3G-related emergency department visits before, during and after pegcetacoplan treatment.",{"measure":123,"description":124,"timeFrame":100},"Annualised number of primary IC-MPGN-related emergency department visits","Annualised number of primary IC-MPGN-related emergency department visits before, during and after pegcetacoplan treatment.",null,{"allocation":127,"interventionModel":128,"interventionModelDescription":125,"primaryPurpose":129,"observationalModel":125,"timePerspective":125,"maskingInfo":130},"NA","SINGLE_GROUP","TREATMENT",{"masking":131,"maskingDescription":125,"whoMasked":125},"NONE","The purpose of this study is to evaluate the effectiveness and safety of pegcetacoplan in patients with C3G and primary IC-MPGN in the real-world setting post-approval, as well as to characterise relevant biomarkers and their association with pegcetacoplan treatment. This will provide new information that was not evaluated in the clinical programme and help with understanding the long-term benefit-risk of pegcetacoplan in a broad patient population. This study will evaluate patient data prior to, during and after the use of pegcetacoplan to assess how the real-world use of pegcetacoplan impacts clinical outcomes and health care resource utilisation. This knowledge will contribute to informed clinical decision-making and provide guidance for effective disease management of patients with C3G or primary IC-MPGN.",[134],{"label":135,"type":136,"description":125,"interventionNames":137},"Single arm","OTHER",[138],"Drug: Pegcetacoplan",[140],{"type":141,"name":142,"description":143,"armGroupLabels":144,"otherNames":125},"DRUG","Pegcetacoplan","Solution for infusion for subcutaneous use according to drug use in the real world.",[135],[146],{"name":147,"role":148,"phone":149,"phoneExt":125,"email":150},"Study Physician","CONTACT","+46 86972000","medical.info@sobi.com",[152,165,174,185,194,203,209,220,229,238,247,256,265,277,287,297,306,315,321,331,337,347,353,364,373,382,391,400,409,418,427,433,438,444,450,459,468,477,488,497,506,515,524,533,538,547,556,565,574,583,592,602,611,620,631,640,645,654,663,672,681,687,696,707,715,721,731,740,749,758,764,770,776,782,798,807,813,819,828,837,843,849,858,867,873,884,893,902,911,920,926,937,948,957,966,975,983,989,995,1004,1013],{"facility":153,"status":154,"city":155,"state":125,"zip":156,"country":157,"countryCode":158,"cosmosGeoPoint":159,"geoPoint":164,"contacts":125},"Nepean Hospital","NOT_YET_RECRUITING","Kingswood","2747","Australia","AU",{"type":160,"coordinates":161},"Point",[162,163],150.72346,-33.75614,{"lat":163,"lon":162},{"facility":166,"status":154,"city":167,"state":125,"zip":168,"country":157,"countryCode":158,"cosmosGeoPoint":169,"geoPoint":173,"contacts":125},"Princess Alexandra Hospital","Woolloongabba","4102",{"type":160,"coordinates":170},[171,172],153.03655,-27.48855,{"lat":172,"lon":171},{"facility":175,"status":154,"city":176,"state":125,"zip":177,"country":178,"countryCode":179,"cosmosGeoPoint":180,"geoPoint":184,"contacts":125},"Medizinische Universität Graz","Graz","8010","Austria","AT",{"type":160,"coordinates":181},[182,183],15.44197,47.06733,{"lat":183,"lon":182},{"facility":186,"status":154,"city":187,"state":125,"zip":188,"country":178,"countryCode":179,"cosmosGeoPoint":189,"geoPoint":193,"contacts":125},"Uniklinik Innsbruck","Innsbruck","6020",{"type":160,"coordinates":190},[191,192],11.39454,47.26266,{"lat":192,"lon":191},{"facility":195,"status":154,"city":196,"state":125,"zip":197,"country":178,"countryCode":179,"cosmosGeoPoint":198,"geoPoint":202,"contacts":125},"Allgemeines Krankenhaus Wien Universitätsklinik","Vienna","1090",{"type":160,"coordinates":199},[200,201],16.37208,48.20849,{"lat":201,"lon":200},{"facility":204,"status":154,"city":196,"state":125,"zip":205,"country":178,"countryCode":179,"cosmosGeoPoint":206,"geoPoint":208,"contacts":125},"Klinik Ottakring","1140",{"type":160,"coordinates":207},[200,201],{"lat":201,"lon":200},{"facility":210,"status":154,"city":211,"state":125,"zip":212,"country":213,"countryCode":214,"cosmosGeoPoint":215,"geoPoint":219,"contacts":125},"Cliniques Universitaires Saint-Luc","Brussels","1200","Belgium","BE",{"type":160,"coordinates":216},[217,218],4.34878,50.85045,{"lat":218,"lon":217},{"facility":221,"status":154,"city":222,"state":125,"zip":223,"country":213,"countryCode":214,"cosmosGeoPoint":224,"geoPoint":228,"contacts":125},"University hosptial of Antwerpen","Edegem","2650",{"type":160,"coordinates":225},[226,227],4.44504,51.15662,{"lat":227,"lon":226},{"facility":230,"status":154,"city":231,"state":125,"zip":232,"country":213,"countryCode":214,"cosmosGeoPoint":233,"geoPoint":237,"contacts":125},"Grand Hôpital de Charleroi","Gilly","6060",{"type":160,"coordinates":234},[235,236],4.4789,50.42449,{"lat":236,"lon":235},{"facility":239,"status":154,"city":240,"state":125,"zip":241,"country":213,"countryCode":214,"cosmosGeoPoint":242,"geoPoint":246,"contacts":125},"UZ Leuven","Leuven","3000",{"type":160,"coordinates":243},[244,245],4.70093,50.87959,{"lat":245,"lon":244},{"facility":248,"status":154,"city":249,"state":125,"zip":250,"country":213,"countryCode":214,"cosmosGeoPoint":251,"geoPoint":255,"contacts":125},"Centre Hospitalier Universitaire de Liege","Liège","4000",{"type":160,"coordinates":252},[253,254],5.56749,50.63373,{"lat":254,"lon":253},{"facility":257,"status":154,"city":258,"state":125,"zip":259,"country":213,"countryCode":214,"cosmosGeoPoint":260,"geoPoint":264,"contacts":125},"CHU UCL Namur","Namur","5000",{"type":160,"coordinates":261},[262,263],4.86746,50.4669,{"lat":263,"lon":262},{"facility":266,"status":154,"city":267,"state":268,"zip":269,"country":270,"countryCode":271,"cosmosGeoPoint":272,"geoPoint":276,"contacts":125},"University of Calgary - Alberta Children's Hospital","Calgary","Alberta","T3B 6A8","Canada","CA",{"type":160,"coordinates":273},[274,275],-114.08529,51.05011,{"lat":275,"lon":274},{"facility":278,"status":154,"city":279,"state":280,"zip":281,"country":270,"countryCode":271,"cosmosGeoPoint":282,"geoPoint":286,"contacts":125},"British Columbia Childrens' & Women's Hospital Center","Vancouver","British Columbia","V6H 3V4",{"type":160,"coordinates":283},[284,285],-123.11934,49.24966,{"lat":285,"lon":284},{"facility":288,"status":154,"city":289,"state":290,"zip":291,"country":270,"countryCode":271,"cosmosGeoPoint":292,"geoPoint":296,"contacts":125},"Kingston General Hospital","Kingston","Ontario","K7L 2V7",{"type":160,"coordinates":293},[294,295],-76.48098,44.22976,{"lat":295,"lon":294},{"facility":298,"status":154,"city":299,"state":290,"zip":300,"country":270,"countryCode":271,"cosmosGeoPoint":301,"geoPoint":305,"contacts":125},"London Health Sciences Centre (LHSC) - Victoria Hospital","London","N6A 5W9",{"type":160,"coordinates":302},[303,304],-81.23304,42.98339,{"lat":304,"lon":303},{"facility":307,"status":154,"city":308,"state":290,"zip":309,"country":270,"countryCode":271,"cosmosGeoPoint":310,"geoPoint":314,"contacts":125},"The Hospital for Sick Children","Toronto","M5G 1E8",{"type":160,"coordinates":311},[312,313],-79.39864,43.70643,{"lat":313,"lon":312},{"facility":316,"status":154,"city":308,"state":290,"zip":317,"country":270,"countryCode":271,"cosmosGeoPoint":318,"geoPoint":320,"contacts":125},"University Health Network","M5G 2C4",{"type":160,"coordinates":319},[312,313],{"lat":313,"lon":312},{"facility":322,"status":154,"city":323,"state":324,"zip":325,"country":270,"countryCode":271,"cosmosGeoPoint":326,"geoPoint":330,"contacts":125},"McGill University","Montreal","Quebec","H3G 1A4",{"type":160,"coordinates":327},[328,329],-73.58781,45.50884,{"lat":329,"lon":328},{"facility":332,"status":154,"city":323,"state":324,"zip":333,"country":270,"countryCode":271,"cosmosGeoPoint":334,"geoPoint":336,"contacts":125},"CHU Sainte-Justine","H3T 1C5",{"type":160,"coordinates":335},[328,329],{"lat":329,"lon":328},{"facility":338,"status":154,"city":339,"state":125,"zip":340,"country":341,"countryCode":125,"cosmosGeoPoint":342,"geoPoint":346,"contacts":125},"Institut klinicke a experimentalni mediciny","Prague","14021","Czechia",{"type":160,"coordinates":343},[344,345],14.42076,50.08804,{"lat":345,"lon":344},{"facility":348,"status":154,"city":339,"state":125,"zip":349,"country":341,"countryCode":125,"cosmosGeoPoint":350,"geoPoint":352,"contacts":125},"Fakultni nemocnice v Motole","16900",{"type":160,"coordinates":351},[344,345],{"lat":345,"lon":344},{"facility":354,"status":154,"city":355,"state":125,"zip":356,"country":357,"countryCode":358,"cosmosGeoPoint":359,"geoPoint":363,"contacts":125},"CHU Bordeaux","Bordeaux","33076","France","FR",{"type":160,"coordinates":360},[361,362],-0.58046,44.84124,{"lat":362,"lon":361},{"facility":365,"status":154,"city":366,"state":125,"zip":367,"country":357,"countryCode":358,"cosmosGeoPoint":368,"geoPoint":372,"contacts":125},"CHU Lyon - Hôpital Femme-Mère-Enfant","Bron","69500",{"type":160,"coordinates":369},[370,371],4.91303,45.73865,{"lat":371,"lon":370},{"facility":374,"status":154,"city":375,"state":125,"zip":376,"country":357,"countryCode":358,"cosmosGeoPoint":377,"geoPoint":381,"contacts":125},"Hopital Henri Mondor","Créteil","94000",{"type":160,"coordinates":378},[379,380],2.46569,48.79266,{"lat":380,"lon":379},{"facility":383,"status":154,"city":384,"state":125,"zip":385,"country":357,"countryCode":358,"cosmosGeoPoint":386,"geoPoint":390,"contacts":125},"Hopital Claude Huriez - CHU Lille","Lille","59000",{"type":160,"coordinates":387},[388,389],3.05512,50.63391,{"lat":389,"lon":388},{"facility":392,"status":154,"city":393,"state":125,"zip":394,"country":357,"countryCode":358,"cosmosGeoPoint":395,"geoPoint":399,"contacts":125},"Hopital de la Conception - APHM","Marseille","13005",{"type":160,"coordinates":396},[397,398],5.38107,43.29695,{"lat":398,"lon":397},{"facility":401,"status":154,"city":402,"state":125,"zip":403,"country":357,"countryCode":358,"cosmosGeoPoint":404,"geoPoint":408,"contacts":125},"Hopital Lapeyronie pt","Montpellier","34090",{"type":160,"coordinates":405},[406,407],3.87635,43.61093,{"lat":407,"lon":406},{"facility":410,"status":154,"city":411,"state":125,"zip":412,"country":357,"countryCode":358,"cosmosGeoPoint":413,"geoPoint":417,"contacts":125},"CHU Nantes - Hôtel Dieu","Nantes","44000",{"type":160,"coordinates":414},[415,416],-1.55336,47.21725,{"lat":416,"lon":415},{"facility":419,"status":154,"city":420,"state":125,"zip":421,"country":357,"countryCode":358,"cosmosGeoPoint":422,"geoPoint":426,"contacts":125},"Hôpital Saint-Louis","Paris","75010",{"type":160,"coordinates":423},[424,425],2.3488,48.85341,{"lat":425,"lon":424},{"facility":428,"status":154,"city":420,"state":125,"zip":429,"country":357,"countryCode":358,"cosmosGeoPoint":430,"geoPoint":432,"contacts":125},"AP-HP Georges-Pompidou European Hospital (Paris)","75015",{"type":160,"coordinates":431},[424,425],{"lat":425,"lon":424},{"facility":434,"status":154,"city":420,"state":125,"zip":429,"country":357,"countryCode":358,"cosmosGeoPoint":435,"geoPoint":437,"contacts":125},"Hôpital Necker - Enfants Malades",{"type":160,"coordinates":436},[424,425],{"lat":425,"lon":424},{"facility":439,"status":154,"city":420,"state":125,"zip":440,"country":357,"countryCode":358,"cosmosGeoPoint":441,"geoPoint":443,"contacts":125},"Hôpital Robert Debré - Paris","75019",{"type":160,"coordinates":442},[424,425],{"lat":425,"lon":424},{"facility":445,"status":154,"city":420,"state":125,"zip":446,"country":357,"countryCode":358,"cosmosGeoPoint":447,"geoPoint":449,"contacts":125},"Tenon CHU Paris Est","75020",{"type":160,"coordinates":448},[424,425],{"lat":425,"lon":424},{"facility":451,"status":154,"city":452,"state":125,"zip":453,"country":357,"countryCode":358,"cosmosGeoPoint":454,"geoPoint":458,"contacts":125},"CHU Reims - Hôpital Maison Blanche","Reims","51200",{"type":160,"coordinates":455},[456,457],4.02853,49.26526,{"lat":457,"lon":456},{"facility":460,"status":154,"city":461,"state":125,"zip":462,"country":357,"countryCode":358,"cosmosGeoPoint":463,"geoPoint":467,"contacts":125},"CHU Strasbourg - Nouvel Hôpital Civil","Strasbourg","67000",{"type":160,"coordinates":464},[465,466],7.74553,48.58392,{"lat":466,"lon":465},{"facility":469,"status":154,"city":470,"state":125,"zip":471,"country":357,"countryCode":358,"cosmosGeoPoint":472,"geoPoint":476,"contacts":125},"Hôpital Foch","Suresnes","92150",{"type":160,"coordinates":473},[474,475],2.22929,48.87143,{"lat":475,"lon":474},{"facility":478,"status":154,"city":479,"state":125,"zip":480,"country":481,"countryCode":482,"cosmosGeoPoint":483,"geoPoint":487,"contacts":125},"Universitaetsklinikum Aachen AOeR","Aachen","52074","Germany","DE",{"type":160,"coordinates":484},[485,486],6.08342,50.77664,{"lat":486,"lon":485},{"facility":489,"status":154,"city":490,"state":125,"zip":491,"country":481,"countryCode":482,"cosmosGeoPoint":492,"geoPoint":496,"contacts":125},"Charité - Campus Virchow-Klinikum","Berlin","13355",{"type":160,"coordinates":493},[494,495],13.41053,52.52437,{"lat":495,"lon":494},{"facility":498,"status":154,"city":499,"state":125,"zip":500,"country":481,"countryCode":482,"cosmosGeoPoint":501,"geoPoint":505,"contacts":125},"University Hospital Cologne","Cologne","50937",{"type":160,"coordinates":502},[503,504],6.95,50.93333,{"lat":504,"lon":503},{"facility":507,"status":154,"city":508,"state":125,"zip":509,"country":481,"countryCode":482,"cosmosGeoPoint":510,"geoPoint":514,"contacts":125},"Universitaetsklinikum Carl Gustav Carus TU Dresden","Dresden","1307",{"type":160,"coordinates":511},[512,513],13.73832,51.05089,{"lat":513,"lon":512},{"facility":516,"status":154,"city":517,"state":125,"zip":518,"country":481,"countryCode":482,"cosmosGeoPoint":519,"geoPoint":523,"contacts":125},"Universitaetsklinikum Erlangen","Erlangen","91054",{"type":160,"coordinates":520},[521,522],11.00783,49.59099,{"lat":522,"lon":521},{"facility":525,"status":154,"city":526,"state":125,"zip":527,"country":481,"countryCode":482,"cosmosGeoPoint":528,"geoPoint":532,"contacts":125},"Universitaetsklinikum Essen","Essen","45133",{"type":160,"coordinates":529},[530,531],7.01228,51.45657,{"lat":531,"lon":530},{"facility":525,"status":154,"city":526,"state":125,"zip":534,"country":481,"countryCode":482,"cosmosGeoPoint":535,"geoPoint":537,"contacts":125},"45147",{"type":160,"coordinates":536},[530,531],{"lat":531,"lon":530},{"facility":539,"status":154,"city":540,"state":125,"zip":541,"country":481,"countryCode":482,"cosmosGeoPoint":542,"geoPoint":546,"contacts":125},"Universitaetsklinikum Hamburg-Eppendorf","Hamburg","20246",{"type":160,"coordinates":543},[544,545],9.99302,53.55073,{"lat":545,"lon":544},{"facility":548,"status":154,"city":549,"state":125,"zip":550,"country":481,"countryCode":482,"cosmosGeoPoint":551,"geoPoint":555,"contacts":125},"Medizinische Hochschule Hannover","Hanover","30625",{"type":160,"coordinates":552},[553,554],9.73322,52.37052,{"lat":554,"lon":553},{"facility":557,"status":154,"city":558,"state":125,"zip":559,"country":481,"countryCode":482,"cosmosGeoPoint":560,"geoPoint":564,"contacts":125},"Universitaetsklinikum Heidelberg","Heidelberg","69120",{"type":160,"coordinates":561},[562,563],8.69079,49.40768,{"lat":563,"lon":562},{"facility":566,"status":154,"city":567,"state":125,"zip":568,"country":481,"countryCode":482,"cosmosGeoPoint":569,"geoPoint":573,"contacts":125},"Universitaetsklinikum Leipzig AoeR","Leipzig","4103",{"type":160,"coordinates":570},[571,572],12.37129,51.33962,{"lat":572,"lon":571},{"facility":575,"status":154,"city":576,"state":125,"zip":577,"country":481,"countryCode":482,"cosmosGeoPoint":578,"geoPoint":582,"contacts":125},"Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz","Mainz","55131",{"type":160,"coordinates":579},[580,581],8.28008,49.98185,{"lat":581,"lon":580},{"facility":584,"status":154,"city":585,"state":125,"zip":586,"country":481,"countryCode":482,"cosmosGeoPoint":587,"geoPoint":591,"contacts":125},"Universitaetsklinikum Regensburg","Regensburg","93053",{"type":160,"coordinates":588},[589,590],12.10161,49.01513,{"lat":590,"lon":589},{"facility":593,"status":594,"city":595,"state":125,"zip":596,"country":481,"countryCode":482,"cosmosGeoPoint":597,"geoPoint":601,"contacts":125},"Robert-Bosch-Krankenhaus","RECRUITING","Stuttgart","70376",{"type":160,"coordinates":598},[599,600],9.17702,48.78232,{"lat":600,"lon":599},{"facility":603,"status":154,"city":604,"state":125,"zip":605,"country":481,"countryCode":482,"cosmosGeoPoint":606,"geoPoint":610,"contacts":125},"Nephrologisches Zentrum Villingen-Schwenningen","Villingen-Schwenningen","78052",{"type":160,"coordinates":607},[608,609],8.49358,48.06226,{"lat":609,"lon":608},{"facility":612,"status":154,"city":613,"state":125,"zip":614,"country":481,"countryCode":482,"cosmosGeoPoint":615,"geoPoint":619,"contacts":125},"Nierenzentrum Wiesbaden","Wiesbaden","65191",{"type":160,"coordinates":616},[617,618],8.24435,50.08601,{"lat":618,"lon":617},{"facility":621,"status":154,"city":622,"state":125,"zip":623,"country":624,"countryCode":625,"cosmosGeoPoint":626,"geoPoint":630,"contacts":125},"Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari","Bari","70124","Italy","IT",{"type":160,"coordinates":627},[628,629],16.86982,41.12066,{"lat":629,"lon":628},{"facility":632,"status":154,"city":633,"state":125,"zip":634,"country":624,"countryCode":625,"cosmosGeoPoint":635,"geoPoint":639,"contacts":125},"Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS","Bologna","40138",{"type":160,"coordinates":636},[637,638],11.33875,44.49381,{"lat":638,"lon":637},{"facility":641,"status":154,"city":633,"state":125,"zip":634,"country":624,"countryCode":625,"cosmosGeoPoint":642,"geoPoint":644,"contacts":125},"Azienda Ospedaliero Universitaria di Bologna Policlinico S Orsola Malpighi",{"type":160,"coordinates":643},[637,638],{"lat":638,"lon":637},{"facility":646,"status":154,"city":647,"state":125,"zip":648,"country":624,"countryCode":625,"cosmosGeoPoint":649,"geoPoint":653,"contacts":125},"Ospedali Riuniti di Foggia","Foggia","71100",{"type":160,"coordinates":650},[651,652],15.55188,41.45845,{"lat":652,"lon":651},{"facility":655,"status":154,"city":656,"state":125,"zip":657,"country":624,"countryCode":625,"cosmosGeoPoint":658,"geoPoint":662,"contacts":125},"Azienda Ospedaliera Universitaria Gaetano Martino","Messina","98123",{"type":160,"coordinates":659},[660,661],15.55256,38.19394,{"lat":661,"lon":660},{"facility":664,"status":154,"city":665,"state":125,"zip":666,"country":624,"countryCode":625,"cosmosGeoPoint":667,"geoPoint":671,"contacts":125},"Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico","Milan","20122",{"type":160,"coordinates":668},[669,670],9.18951,45.46427,{"lat":670,"lon":669},{"facility":673,"status":154,"city":674,"state":125,"zip":675,"country":624,"countryCode":625,"cosmosGeoPoint":676,"geoPoint":680,"contacts":125},"Ospedale Pediatrico Bambino Gesù","Roma","165",{"type":160,"coordinates":677},[678,679],11.10642,44.99364,{"lat":679,"lon":678},{"facility":682,"status":154,"city":674,"state":125,"zip":683,"country":624,"countryCode":625,"cosmosGeoPoint":684,"geoPoint":686,"contacts":125},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","168",{"type":160,"coordinates":685},[678,679],{"lat":679,"lon":678},{"facility":688,"status":154,"city":689,"state":125,"zip":690,"country":624,"countryCode":625,"cosmosGeoPoint":691,"geoPoint":695,"contacts":125},"Azienda Ospedaliero-Universitaria Santa Maria della Misericordia","Udine","33100",{"type":160,"coordinates":692},[693,694],13.23715,46.0693,{"lat":694,"lon":693},{"facility":697,"status":154,"city":698,"state":125,"zip":699,"country":700,"countryCode":701,"cosmosGeoPoint":702,"geoPoint":706,"contacts":125},"King Faisal Specialist Hospital & Research Center","Jeddah","66697","Saudi Arabia","SA",{"type":160,"coordinates":703},[704,705],39.18624,21.49012,{"lat":705,"lon":704},{"facility":697,"status":154,"city":708,"state":125,"zip":709,"country":700,"countryCode":701,"cosmosGeoPoint":710,"geoPoint":714,"contacts":125},"Riyadh","11211",{"type":160,"coordinates":711},[712,713],46.72185,24.68773,{"lat":713,"lon":712},{"facility":716,"status":154,"city":708,"state":125,"zip":717,"country":700,"countryCode":701,"cosmosGeoPoint":718,"geoPoint":720,"contacts":125},"King Fahad Medical City","11525",{"type":160,"coordinates":719},[712,713],{"lat":713,"lon":712},{"facility":722,"status":594,"city":723,"state":125,"zip":724,"country":725,"countryCode":125,"cosmosGeoPoint":726,"geoPoint":730,"contacts":125},"Keimyung University Dongsan Hospital","Daegu","42601","South Korea",{"type":160,"coordinates":727},[728,729],128.59111,35.87028,{"lat":729,"lon":728},{"facility":732,"status":154,"city":733,"state":125,"zip":734,"country":725,"countryCode":125,"cosmosGeoPoint":735,"geoPoint":739,"contacts":125},"Chungnam National University Hospital","Daejeon","35015",{"type":160,"coordinates":736},[737,738],127.38493,36.34913,{"lat":738,"lon":737},{"facility":741,"status":154,"city":742,"state":125,"zip":743,"country":725,"countryCode":125,"cosmosGeoPoint":744,"geoPoint":748,"contacts":125},"Seoul National University Bundang Hospital","Seongnam","13597",{"type":160,"coordinates":745},[746,747],129.30505,35.48474,{"lat":747,"lon":746},{"facility":750,"status":154,"city":751,"state":125,"zip":752,"country":725,"countryCode":125,"cosmosGeoPoint":753,"geoPoint":757,"contacts":125},"Seoul National University Hospital","Seoul","3080",{"type":160,"coordinates":754},[755,756],126.9784,37.566,{"lat":756,"lon":755},{"facility":759,"status":154,"city":751,"state":125,"zip":760,"country":725,"countryCode":125,"cosmosGeoPoint":761,"geoPoint":763,"contacts":125},"Severance Hospital, Yonsei University Health System","3722",{"type":160,"coordinates":762},[755,756],{"lat":756,"lon":755},{"facility":765,"status":154,"city":751,"state":125,"zip":766,"country":725,"countryCode":125,"cosmosGeoPoint":767,"geoPoint":769,"contacts":125},"Samsung Medical Center","6351",{"type":160,"coordinates":768},[755,756],{"lat":756,"lon":755},{"facility":771,"status":154,"city":751,"state":125,"zip":772,"country":725,"countryCode":125,"cosmosGeoPoint":773,"geoPoint":775,"contacts":125},"The Catholic University of Korea, Seoul St. Mary's Hospital","6591",{"type":160,"coordinates":774},[755,756],{"lat":756,"lon":755},{"facility":777,"status":154,"city":751,"state":125,"zip":778,"country":725,"countryCode":125,"cosmosGeoPoint":779,"geoPoint":781,"contacts":125},"Seoul Metropolitan Government Seoul National University Boramae Medical Center","7061",{"type":160,"coordinates":780},[755,756],{"lat":756,"lon":755},{"facility":783,"status":594,"city":784,"state":125,"zip":785,"country":786,"countryCode":787,"cosmosGeoPoint":788,"geoPoint":792,"contacts":793},"Complejo Hospitalario Universitario A Coruña","A Coruña","15006","Spain","ES",{"type":160,"coordinates":789},[790,791],-8.396,43.37135,{"lat":791,"lon":790},[794,796],{"name":795,"role":148,"phone":125,"phoneExt":125,"email":125},"Catuxa Rodriguez",{"name":795,"role":797,"phone":125,"phoneExt":125,"email":125},"PRINCIPAL_INVESTIGATOR",{"facility":799,"status":154,"city":800,"state":125,"zip":801,"country":786,"countryCode":787,"cosmosGeoPoint":802,"geoPoint":806,"contacts":125},"Hospital Universitari Vall d'Hebron - VHIR","Barcelona","8024",{"type":160,"coordinates":803},[804,805],2.15899,41.38879,{"lat":805,"lon":804},{"facility":808,"status":154,"city":800,"state":125,"zip":809,"country":786,"countryCode":787,"cosmosGeoPoint":810,"geoPoint":812,"contacts":125},"Hospital Clinic de Barcelona","8036",{"type":160,"coordinates":811},[804,805],{"lat":805,"lon":804},{"facility":814,"status":154,"city":800,"state":125,"zip":815,"country":786,"countryCode":787,"cosmosGeoPoint":816,"geoPoint":818,"contacts":125},"Hospital Sant Joan de Deu","8950",{"type":160,"coordinates":817},[804,805],{"lat":805,"lon":804},{"facility":820,"status":154,"city":821,"state":125,"zip":822,"country":786,"countryCode":787,"cosmosGeoPoint":823,"geoPoint":827,"contacts":125},"Hospital Universitario de la Palma","Las Palmas","35003",{"type":160,"coordinates":824},[825,826],-16.16555,28.58232,{"lat":826,"lon":825},{"facility":829,"status":154,"city":830,"state":125,"zip":831,"country":786,"countryCode":787,"cosmosGeoPoint":832,"geoPoint":836,"contacts":125},"Hospital General Universitario Gregorio Marañon","Madrid","28007",{"type":160,"coordinates":833},[834,835],-3.70256,40.4165,{"lat":835,"lon":834},{"facility":838,"status":154,"city":830,"state":125,"zip":839,"country":786,"countryCode":787,"cosmosGeoPoint":840,"geoPoint":842,"contacts":125},"Hospital Universitario 12 de Octubre","28041",{"type":160,"coordinates":841},[834,835],{"lat":835,"lon":834},{"facility":844,"status":154,"city":830,"state":125,"zip":845,"country":786,"countryCode":787,"cosmosGeoPoint":846,"geoPoint":848,"contacts":125},"Hospital La Paz","28046",{"type":160,"coordinates":847},[834,835],{"lat":835,"lon":834},{"facility":850,"status":154,"city":851,"state":125,"zip":852,"country":786,"countryCode":787,"cosmosGeoPoint":853,"geoPoint":857,"contacts":125},"Hospital Regional Universitario de Malaga","Málaga","29010",{"type":160,"coordinates":854},[855,856],-4.42034,36.72016,{"lat":856,"lon":855},{"facility":859,"status":154,"city":860,"state":125,"zip":861,"country":786,"countryCode":787,"cosmosGeoPoint":862,"geoPoint":866,"contacts":125},"Hospital Doctor Peset Valencia","Valencia","46017",{"type":160,"coordinates":863},[864,865],-0.37966,39.47391,{"lat":865,"lon":864},{"facility":868,"status":154,"city":860,"state":125,"zip":869,"country":786,"countryCode":787,"cosmosGeoPoint":870,"geoPoint":872,"contacts":125},"Hospital Universitari i Politecnic La Fe","46026",{"type":160,"coordinates":871},[864,865],{"lat":865,"lon":864},{"facility":874,"status":154,"city":875,"state":125,"zip":876,"country":877,"countryCode":878,"cosmosGeoPoint":879,"geoPoint":883,"contacts":125},"University of Basel","Basel","4031","Switzerland","CH",{"type":160,"coordinates":880},[881,882],7.57327,47.55839,{"lat":882,"lon":881},{"facility":885,"status":154,"city":886,"state":125,"zip":887,"country":877,"countryCode":878,"cosmosGeoPoint":888,"geoPoint":892,"contacts":125},"Inselspital - University Hospital Bern","Bern","3010",{"type":160,"coordinates":889},[890,891],7.44744,46.94809,{"lat":891,"lon":890},{"facility":894,"status":154,"city":895,"state":125,"zip":896,"country":877,"countryCode":878,"cosmosGeoPoint":897,"geoPoint":901,"contacts":125},"Hôpitaux Universitaires de Genève - HUG","Geneva","1205",{"type":160,"coordinates":898},[899,900],6.14569,46.20222,{"lat":900,"lon":899},{"facility":903,"status":594,"city":904,"state":125,"zip":905,"country":877,"countryCode":878,"cosmosGeoPoint":906,"geoPoint":910,"contacts":125},"CHUV, Lausanne University Hospital","Lausanne","1005",{"type":160,"coordinates":907},[908,909],6.63282,46.516,{"lat":909,"lon":908},{"facility":912,"status":154,"city":913,"state":125,"zip":914,"country":877,"countryCode":878,"cosmosGeoPoint":915,"geoPoint":919,"contacts":125},"University Hospital Zurich - Children's Hospital Zurich","Zurich","8008",{"type":160,"coordinates":916},[917,918],8.55,47.36667,{"lat":918,"lon":917},{"facility":921,"status":154,"city":913,"state":125,"zip":922,"country":877,"countryCode":878,"cosmosGeoPoint":923,"geoPoint":925,"contacts":125},"University Hospital Zurich","8091",{"type":160,"coordinates":924},[917,918],{"lat":918,"lon":917},{"facility":927,"status":154,"city":928,"state":125,"zip":929,"country":930,"countryCode":931,"cosmosGeoPoint":932,"geoPoint":936,"contacts":125},"Taipei Veterans General Hospital","Taipei","11217","Taiwan","TW",{"type":160,"coordinates":933},[934,935],121.52639,25.05306,{"lat":935,"lon":934},{"facility":938,"status":154,"city":939,"state":125,"zip":940,"country":941,"countryCode":942,"cosmosGeoPoint":943,"geoPoint":947,"contacts":125},"Cambridge University Hospitals NHS Foundation Trust","Cambridge","CB2 2QQ","United Kingdom","UK",{"type":160,"coordinates":944},[945,946],0.11667,52.2,{"lat":946,"lon":945},{"facility":949,"status":154,"city":950,"state":125,"zip":951,"country":941,"countryCode":942,"cosmosGeoPoint":952,"geoPoint":956,"contacts":125},"University Hospital of Wales","Cardiff","CF14 4XW",{"type":160,"coordinates":953},[954,955],-3.18,51.48,{"lat":955,"lon":954},{"facility":958,"status":154,"city":959,"state":125,"zip":960,"country":941,"countryCode":942,"cosmosGeoPoint":961,"geoPoint":965,"contacts":125},"Royal Hospital for Children","Glasgow","G51 4TF",{"type":160,"coordinates":962},[963,964],-4.25763,55.86515,{"lat":964,"lon":963},{"facility":967,"status":154,"city":968,"state":125,"zip":969,"country":941,"countryCode":942,"cosmosGeoPoint":970,"geoPoint":974,"contacts":125},"Leicester General Hospital","Leicester","LE1 7RH",{"type":160,"coordinates":971},[972,973],-1.13169,52.6386,{"lat":973,"lon":972},{"facility":976,"status":154,"city":299,"state":125,"zip":977,"country":941,"countryCode":942,"cosmosGeoPoint":978,"geoPoint":982,"contacts":125},"Royal Free Hospital","NW3 2QG",{"type":160,"coordinates":979},[980,981],-0.12574,51.50853,{"lat":981,"lon":980},{"facility":984,"status":154,"city":299,"state":125,"zip":985,"country":941,"countryCode":942,"cosmosGeoPoint":986,"geoPoint":988,"contacts":125},"Evelina London Children's Hospital","SE1 7EH",{"type":160,"coordinates":987},[980,981],{"lat":981,"lon":980},{"facility":990,"status":154,"city":299,"state":125,"zip":991,"country":941,"countryCode":942,"cosmosGeoPoint":992,"geoPoint":994,"contacts":125},"Imperial College Healthcare NHS Trust (ICH)","W12 0HS",{"type":160,"coordinates":993},[980,981],{"lat":981,"lon":980},{"facility":996,"status":154,"city":997,"state":125,"zip":998,"country":941,"countryCode":942,"cosmosGeoPoint":999,"geoPoint":1003,"contacts":125},"Royal Manchester Children's Hospital","Manchester","M13 9WL",{"type":160,"coordinates":1000},[1001,1002],-2.23743,53.48095,{"lat":1002,"lon":1001},{"facility":1005,"status":154,"city":1006,"state":125,"zip":1007,"country":941,"countryCode":942,"cosmosGeoPoint":1008,"geoPoint":1012,"contacts":125},"Newcastle Hospital NHS Foundation Trust","Newcastle","NE1 4LP",{"type":160,"coordinates":1009},[1010,1011],-5.88979,54.21804,{"lat":1011,"lon":1010},{"facility":1014,"status":154,"city":1015,"state":125,"zip":1016,"country":941,"countryCode":942,"cosmosGeoPoint":1017,"geoPoint":1021,"contacts":125},"Salford Care Organisation","Salford","M8 8HD",{"type":160,"coordinates":1018},[1019,1020],-2.29042,53.48771,{"lat":1020,"lon":1019},{"type":1023,"investigatorFullName":125,"investigatorTitle":125,"investigatorAffiliation":125,"oldNameTitle":125,"oldOrganization":125},"SPONSOR",[1025],{"name":1026,"class":6},"IQVIA Pty Ltd","100650424","phase-4-real-world-effectiveness-and-safety-of-pegcetacoplan-in-patients-with-c3g-or-ic-mpg-a-multi-country-study-100650424",false,"NCT07746895","Real-World Effectiveness and Safety of Pegcetacoplan in Patients With C3G or IC-MPG: A Multi-Country Study","Real-World Effectiveness and Safety of Pegcetacoplan in Patients With C3 Glomerulopathy (C3G) or Primary Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN): A Multi-Country Study","Inclusion Criteria:\n\n* Have received or plan to receive pegcetacoplan for the treatment of C3G or primary IC-MPGN.\n* Provided signed and dated informed consent. For participants under the legal age signed and dated informed consent is provided by the participant's legally authorised representative. Assent will also be obtained from paediatric participants as required by local regulations.\n\nExclusion Criteria:\n\n* Receiving an investigational treatment for C3G or primary IC-MPGN at the time of pegcetacoplan initiation.\n* Initiated treatment with pegcetacoplan in an interventional study.","ALL",{"count":1036,"type":1037},150,"ESTIMATED","INTERVENTIONAL",[1040],"PHASE4","The purpose of this study is to evaluate the effectiveness and safety of Pegcetacoplan in patients with C3G and primary IC-MPGN in the real-world setting. This study will also assess biomarkers not routinely measured in clinical practice. Results will support the long-term evaluation of the benefit-risk profile of pegcetacoplan in a broad patient population, informing clinical decision-making.",[1043,1044],"C3 Glomerulopathy (C3G)","Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN)",[1046,1047,1048,142,1049,1050,1051],"C3 Glomerulopathy","Primary Immune Complex Membranoproliferative","Glomerulonephritis","Glomerulopathy","Nephrology","Rare disease","2026-09-08",{"date":1054,"type":1055},"2026-09-09","ACTUAL",{"date":1057,"type":1055},"2026-08-05",{"date":1059,"type":1037},"2032-01-31",{"name":5,"class":6},101]