[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648508":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":22,"centralContacts":23,"locations":29,"responsibleParty":50,"collaborators":22,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":22,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":22,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":75,"whyStopped":22,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Stanford University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Ray tracing guided LASIK surgery","ACTIVE_COMPARATOR","LASIK",[13],"Device: Ray tracing guided LASIK surgery",{"label":15,"type":10,"description":16,"interventionNames":17},"SMILE surgery","SMILE",[13],[19],{"type":20,"name":9,"description":11,"armGroupLabels":21,"otherNames":22},"DEVICE",[9,15],null,[24],{"name":25,"role":26,"phone":27,"phoneExt":22,"email":28},"Edward E Manche, MD","CONTACT","1-650-498-7020","edward.manche@stanford.edu",[30],{"facility":31,"status":22,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Byers Eye Institute","Palo Alto","California","94303","United States","US",{"type":38,"coordinates":39},"Point",[40,41],-122.14302,37.44188,{"lat":41,"lon":40},[44,48],{"name":45,"role":26,"phone":46,"phoneExt":22,"email":47},"Edward Manche E Manche, MD","650-498-7020","cornea@stanford.edu",{"name":25,"role":49,"phone":22,"phoneExt":22,"email":22},"PRINCIPAL_INVESTIGATOR",{"type":49,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"Edward E. Manche","Professor of Ophthalmology","100648508","phase-4-smile-surgery-in-one-eye-compared-to-ray-tracing-guided-lasik-surgery-in-the-fellow-eye-100648508",false,"NCT07721714","SMILE Surgery in One Eye Compared to Ray Tracing-guided LASIK Surgery in the Fellow Eye","A Prospective Randomized Comparison of SMILE Surgery to Ray Tracing-Guided LASIK Surgery","Inclusion Criteria:\n\nSubjects age 22 and older with healthy eyes. Nearsightedness between -1.00 diopters and -8.00 diopters.\n\nSubjects with less than or equal to 3.00 diopters of astigmatism.\n\nExclusion Criteria:\n\nSubjects under the age of 22. Subjects with excessively thin corneas. Subjects with topographic evidence of keratoconus. Subjects with ectactic eye disorders. Subjects with autoimmune diseases. Subjects who are pregnant or nursing. Subjects must have similar levels of nearsightedness in each eye. They can not be more than 1.5 diopter of difference between eyes.\n\nSubjects with more than 3.00 diopters of astigmatism Subjects must have similar levels of astigmatism in each eye. They can not have more than 0.75 diopters of difference between eyes.","ALL","22 Years","59 Years",{"count":64,"type":65},62,"ESTIMATED","INTERVENTIONAL",[68],"PHASE4","Participants will undergo LASIK surgery in one eye using ray tracing guided technology in one eye and LASIK surgery in the other eye using wavefront guided technology. We are comparing outcomes between the two technologies as measured by self reported quality of vision and quality of life outcomes using validated questionnaires before and after surgery. We will also be comparing outcomes between the two technologies including measurement of low contrast visual acuity,and best spectacle corrected visual acuity.",[71,72],"Myopia","Astigmatism",[74,11,16],"Ray-tracing","NOT_YET_RECRUITING","2026-07-18",{"date":78,"type":79},"2026-07-23","ACTUAL",{"date":81,"type":65},"2026-08-05",{"date":83,"type":65},"2029-07-31",{"name":5,"class":6},1]