[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648424":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":11,"centralContacts":23,"locations":11,"responsibleParty":29,"collaborators":11,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":37,"acronym":11,"eligibilityCriteria":38,"healthyVolunteers":35,"sex":39,"minAge":40,"maxAge":11,"enrollmentInfo":41,"targetDuration":11,"studyType":44,"phases":45,"briefSummary":47,"conditions":48,"keywords":11,"overallStatus":53,"whyStopped":11,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":11},{"fullName":5,"class":6},"University Hospital Dubrava","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":11},"TIVA alone","NO_INTERVENTION",null,{"label":13,"type":14,"description":11,"interventionNames":15},"TIVA + bilateral intermediate cervical plexus block with 0,25% levobupivacaine","EXPERIMENTAL",[16],"Procedure: Ultrasound guided bilateral intermediate cervical plexus block",[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":11},"PROCEDURE","Ultrasound guided bilateral intermediate cervical plexus block","Following the induction of general anesthesia in the study group, an ultrasound-guided bilateral intermediate cervical plexus block will be performed.\n\nThe cervical plexus is visualized on the screen as a small cluster of hypoechoic nodules beneath the posterolateral border of the sternocleidomastoid muscle and immediately above the prevertebral fascia. After sterile preparation, a 22-gauge needle is inserted under ultrasound guidance in a lateromedial direction. The needle tip is positioned within the specified space, approximately 2 cm medial to the skin entry point. Following a negative aspiration test, 10 mL of 0.25% levobupivacaine is injected and visualized on the ultrasound screen. The same procedure will be repeated on the contralateral side.",[13],[24],{"name":25,"role":26,"phone":27,"phoneExt":11,"email":28},"Antonija Mihelčić","CONTACT","+385996830715","antonijamihelcic@yahoo.com",{"type":30,"investigatorFullName":31,"investigatorTitle":32,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Antonija Mihelcic","Anesthesiologist","100648424","phase-4-the-association-between-bilateral-intermediate-cervical-plexus-block-and-salivary-biomarkers-of-surgical-stress-response-following-total-thyroidectomy-100648424",false,"NCT07721818","The Association Between Bilateral Intermediate Cervical Plexus Block and Salivary Biomarkers of Surgical Stress Response Following Total Thyroidectomy","Inclusion Criteria:\n\n* ASA I or ASA II\n* euthyroid status\n* signed informed consent\n\nExclusion Criteria:\n\n* patients who refuse to sign the informed consent form\n* infection at the block injection site\n* hypersensitivity or contraindications to the medication used in the study\n* hypo\u002Fhyperthyroidism at the time of surgery\n* presence of substernal goiter\n* additional surgical interventions during the procedure\n* history of previous neck surgery or radiation\n* coagulopathy\n* uncontroled respiratory disease\n* diabetes mellitus\n* autoimune disease\n* chronic corticosteroid therapy\n* smokers\n* pregnant women","ALL","18 Years",{"count":42,"type":43},48,"ESTIMATED","INTERVENTIONAL",[46],"PHASE4","The aim of this study is to evaluate how an ultrasound-guided bilateral intermediate cervical plexus block affects the surgical stress response in individuals undergoing total thyroidectomy. The primary objective is to quantify this physiological response through the analysis of specific stress and inflammatory biomarkers collected from the participants' saliva.\n\nThe clinical trial will encompass a total of 48 patients, randomized equally into two distinct cohorts of 24 participants each. The control group will undergo standard total intravenous anesthesia (TIVA), whereas the experimental group will receive the bilateral intermediate cervical plexus block in combination with the TIVA protocol.\n\nIt is hypothesized that integrating this regional nerve block with total intravenous anesthesia will significantly attenuate the surgical stress response, evidenced by a reduction in salivary biomarker concentration, compared to utilizing TIVA alone during thyroid surgery.\n\nValidating this hypothesis would offer robust scientific evidence to advocate for the routine integration of the bilateral intermediate cervical plexus block into standard anesthetic practices for total thyroidectomy. Ultimately, this approach aims to minimize perioperative stress and facilitate a more rapid postoperative recovery for patients.",[49,50,51,52],"Surgical Stress Response","Total Thyroidectomy","Saliva Collection","Cervical Plexus Block","NOT_YET_RECRUITING","2026-07-20",{"date":56,"type":57},"2026-07-23","ACTUAL",{"date":59,"type":43},"2026-08-01",{"date":61,"type":43},"2027-04",{"name":5,"class":6}]