[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649774":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":11,"centralContacts":23,"locations":11,"responsibleParty":29,"collaborators":11,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":11,"eligibilityCriteria":39,"healthyVolunteers":35,"sex":40,"minAge":41,"maxAge":11,"enrollmentInfo":42,"targetDuration":11,"studyType":45,"phases":46,"briefSummary":48,"conditions":49,"keywords":11,"overallStatus":53,"whyStopped":11,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":11},{"fullName":5,"class":6},"University Hospital Dubrava","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":11},"TIVA alone","NO_INTERVENTION",null,{"label":13,"type":14,"description":11,"interventionNames":15},"TIVA +ultrasound-guided bilateral intermediate cervical plexus block","EXPERIMENTAL",[16],"Procedure: Ultrasound-Guided Bilateral Intermediate Cervical Plexus Block Using 0,25% Levobupivacaine",[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":11},"PROCEDURE","Ultrasound-Guided Bilateral Intermediate Cervical Plexus Block Using 0,25% Levobupivacaine","Following general anesthesia induction, patients in the study group will receive an ultrasound-guided bilateral intermediate cervical plexus block. The cervical plexus will be identified on the ultrasound screen as a small cluster of hypoechoic nodules located beneath the posterolateral border of the sternocleidomastoid muscle and superior to the prevertebral fascia. Under sterile conditions, a 22-gauge needle will be advanced lateromedially using dynamic ultrasound visualization. Once the needle tip is properly positioned within this interfascial space, roughly 2 cm medial to the insertion point, negative aspiration will be confirmed. Subsequently, 10 mL of 0.25% levobupivacaine will be injected under direct ultrasound observation. The identical procedure will then be performed on the contralateral side.",[13],[24],{"name":25,"role":26,"phone":27,"phoneExt":11,"email":28},"Antonija Mihelčić","CONTACT","+38512092444","antonijamihelcic@yahoo.com",{"type":30,"investigatorFullName":31,"investigatorTitle":32,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Antonija Mihelcic","anesthesiologist","100649774","phase-4-the-effect-of-bilateral-intermediate-cervical-plexus-block-on-the-surgical-stress-response-following-total-thyroidectomy-100649774",false,"NCT07740460","The Effect of Bilateral Intermediate Cervical Plexus Block on the Surgical Stress Response Following Total Thyroidectomy","The Effect of Ultrasound-guided Bilateral Intermediate Cervical Plexus Block on Serum Biomarkers of the Surgical Stress Response Following Total Thyroidectomy","Inclusion Criteria:\n\n* ASA I or ASA II\n* euthyroid status\n* signed informed consent\n\nExclusion Criteria:\n\n* patients who refuse to sign the informed consent form\n* infection at the block injection site\n* hypersensitivity or contraindications to the medication used in the study\n* hypo\u002Fhyperthyroidism at the time of surgery\n* presence of substernal goiter\n* additional surgical interventions during the procedure\n* history of previous neck surgery or radiation\n* coagulopathy\n* uncontroled respiratory disease\n* diabetes mellitus\n* autoimune disease\n* chronic corticosteroid therapy\n* smokers\n* pregnant women","ALL","18 Years",{"count":43,"type":44},48,"ESTIMATED","INTERVENTIONAL",[47],"PHASE4","Total thyroidectomy triggers a systemic surgical stress response involving neuroendocrine and inflammatory pathways. Ultrasound-guided bilateral intermediate cervical plexus block (BICPB) is commonly utilized for postoperative analgesia, however, its specific impact on modulating the systemic stress biomarker response remains to be fully elucidated.\n\nTo evaluate the effect of an ultrasound-guided BICPB on the perioperative surgical stress response by comparing changes in specific serum inflammatory and metabolic biomarkers between patients receiving BICPB and those receiving total intravenous anesthesia (TIVA) alone.\n\nIn this prospective, randomized, controlled study, a total of 48 eligible patients scheduled for elective total thyroidectomy will be randomly assigned to two groups of 24 participants each:\n\n* BICPB Group: TIVA combined with an ultrasound-guided bilateral intermediate cervical plexus block.\n* Control Group: TIVA alone.\n\nVenous blood samples will be collected at predefined intervals: preoperatively (baseline), immediately postoperatively, 24 hours and 48 hours post-surgery.\n\nIt is hypothesized that integrating an ultrasound-guided bilateral intermediate cervical plexus block with total intravenous anesthesia (TIVA) will significantly attenuate the surgical stress response, as evidenced by a reduction in specific serum biomarker concentrations (interleukin-6, C-reactive protein, total leukocyte count,cortisol, alpha-amylase, and glucose), compared to utilizing TIVA alone during total thyroidectomy.\n\nTesting this hypothesis aims to provide scientific evidence regarding the routine integration of the bilateral intermediate cervical plexus block into standard anesthetic protocols for total thyroidectomy, with the objective of evaluating its potential to minimize perioperative stress and support postoperative patient recovery.",[50,51,52],"Thyroidectomy","Cervical Plexus Block","Surgical Stress Response","NOT_YET_RECRUITING","2026-08-04",{"date":56,"type":57},"2026-08-07","ACTUAL",{"date":59,"type":44},"2026-08-15",{"date":61,"type":44},"2027-04-15",{"name":5,"class":6}]