[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651347":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":23,"centralContacts":41,"locations":52,"responsibleParty":71,"collaborators":23,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":75,"sex":81,"minAge":82,"maxAge":23,"enrollmentInfo":83,"targetDuration":23,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":102,"whyStopped":23,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"Hospices Civils de Lyon","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Patient with non-life-threatening anemia","All participants undergo standardized clinical assessment, biological sampling, hemoglobin mass measurement using the optimized carbon monoxide rebreathing technique, focused transthoracic echocardiography, near-infrared spectroscopy, blood rheology assessment and symptom questionnaires during a single study visit",[12,13,14,15,16],"Device: Total hemoglobin mass measurement","Diagnostic Test: Focused transthoracic echocardiography","Diagnostic Test: Near-infrared spectroscopy","Other: Blood rheology assessment","Other: Symptom assessment",[18,24,29,33,37],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"DEVICE","Total hemoglobin mass measurement","Measurement of total hemoglobin mass using the optimized carbon monoxide rebreathing technique with capillary carboxyhemoglobin assessment.",[9],null,{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":23},"DIAGNOSTIC_TEST","Focused transthoracic echocardiography","Standardized focused transthoracic echocardiography including assessment of stroke volume, cardiac output and left ventricular filling parameters",[9],{"type":25,"name":30,"description":31,"armGroupLabels":32,"otherNames":23},"Near-infrared spectroscopy","Non-invasive assessment of tissue oxygen saturation and microvascular reactivity using near-infrared spectroscopy.",[9],{"type":6,"name":34,"description":35,"armGroupLabels":36,"otherNames":23},"Blood rheology assessment","Laboratory assessment of blood viscosity, red blood cell deformability and aggregation from additional blood samples.",[9],{"type":6,"name":38,"description":39,"armGroupLabels":40,"otherNames":23},"Symptom assessment","Assessment of fatigue, dyspnea, quality of life and anemia-related symptoms using standardized questionnaires.",[9],[42,48],{"name":43,"role":44,"phone":45,"phoneExt":46,"email":47},"Fabien COISY, MD","CONTACT","6 12 19 43 69","+33","fabien.coisy@chu-lyon.fr",{"name":49,"role":44,"phone":50,"phoneExt":46,"email":51},"Virginie-Eve LVOVSCHI, MD","4 72 11 07 67","virginie.lvovschi@chu-lyon.fr",[53],{"facility":54,"status":23,"city":55,"state":23,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"Emergency department, Edouard Herriot Hospital, Hospices Civils de Lyon","Lyon","69003","France","FR",{"type":60,"coordinates":61},"Point",[62,63],4.84789,45.74906,{"lat":63,"lon":62},[66,67,69],{"name":43,"role":44,"phone":45,"phoneExt":46,"email":47},{"name":49,"role":68,"phone":23,"phoneExt":23,"email":23},"PRINCIPAL_INVESTIGATOR",{"name":43,"role":70,"phone":23,"phoneExt":23,"email":23},"SUB_INVESTIGATOR",{"type":72,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100651347","phenotyping-acute-non-severe-anemia-in-the-emergency-department-100651347",false,"NCT07761104","Phenotyping Acute Non-Severe Anemia in the Emergency Department","A Prospective Interventional Physiological Study for Comprehensive Phenotyping of Adults With Non-Life-Threatening Anemia Presenting to the Emergency Department","PHENOEMEMIA","Inclusion Criteria:\n\n* Adult patients aged 18 years or older.\n* Presentation to the emergency department.\n* Blood hemoglobin concentration \\\u003C10 g\u002FdL.\n* Non-life-threatening clinical condition at presentation.\n* Able to understand the study information and provide written informed consent.\n* Affiliated with a health insurance system.\n\nExclusion Criteria:\n\n* Glasgow Coma Scale score \\\u003C15.\n* Shock Index \\>0.9.\n* Acute clinically significant gastrointestinal, gynecological or other active bleeding within the previous 24 hours.\n* Oxygen saturation \\\u003C92% on room air.\n* Suspected acute myocardial ischemia.\n* Carbon monoxide poisoning.\n* Pregnancy or breastfeeding.\n* Adults lacking legal capacity to provide consent.\n* Individuals deprived of liberty by judicial or administrative decision.\n* Individuals under psychiatric care without consent.\n* Individuals under legal protection (guardianship or curatorship).\n* Individuals not affiliated with a health insurance system.","ALL","18 Years",{"count":84,"type":85},59,"ESTIMATED","INTERVENTIONAL",[88],"NA","Anemia is traditionally diagnosed and managed using circulating hemoglobin concentration (\\[Hb\\]). However, \\[Hb\\] is influenced by plasma volume and may not accurately reflect the total amount of hemoglobin available for oxygen transport. Total hemoglobin mass (Hbmass), measured using the optimized carbon monoxide rebreathing method, provides a direct assessment of the body's oxygen-carrying capacity but has never been extensively investigated in patients presenting to the emergency department with non-life-threatening anemia.\n\nThe hypothesis of the PHENOEMEMIA study is that routine blood hemoglobin concentration is only moderately correlated with Hbmass and therefore does not fully reflect the physiological severity of anemia.\n\nPHENOEMEMIA is a prospective single-center interventional physiological study including adults presenting to the emergency department with non-life-threatening anemia. Each participant undergoes routine clinical assessment, standardized symptom questionnaires, additional blood sampling for biological and hemorheological analyses, focused transthoracic echocardiography, near-infrared spectroscopy assessment of tissue oxygenation, and Hbmass measurement using the optimized carbon monoxide rebreathing technique.\n\nThe primary objective is to evaluate the correlation between blood hemoglobin concentration and Hbmass normalized to body weight. Secondary objectives include describing the relationships between Hbmass, biological markers of anemia, clinical symptoms, cardiac adaptation, blood rheology, tissue oxygenation, and physiological phenotypes of anemia.",[91],"Anemia",[91,93,94,95,96,97,98,99,100,101],"Hemoglobin Mass","Carbon Monoxide Rebreathing","Emergency Medicine","Blood Volume","Hemorheology","Tissue Oxygenation","Near Infrared Spectroscopy","Echocardiography","Physiological Phenotyping","NOT_YET_RECRUITING","2026-08-07",{"date":105,"type":106},"2026-08-12","ACTUAL",{"date":108,"type":85},"2026-12",{"date":110,"type":85},"2028-12",{"name":5,"class":6},1]