[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647811":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":45,"centralContacts":57,"locations":66,"responsibleParty":90,"collaborators":36,"id":92,"slug":93,"hasResults":94,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":98,"eligibilityCriteria":99,"healthyVolunteers":94,"sex":100,"minAge":101,"maxAge":102,"enrollmentInfo":103,"targetDuration":36,"studyType":106,"phases":107,"briefSummary":109,"conditions":110,"keywords":112,"overallStatus":122,"whyStopped":36,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":132},{"fullName":5,"class":6},"University of Lahore","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A - Active PBM + Routine PT","EXPERIMENTAL","830 nm photobiomodulation (200 mW, 46-diode cluster probe, 4 J\u002Fcm², continuous wave) applied over the carpal tunnel region (volar wrist), 3 sessions\u002Fweek for 4 weeks (12 sessions total). Combined with wrist splinting in neutral position (nocturnal) and median nerve gliding exercises (3 × 10 reps twice daily).",[13,14],"Device: Photobiomodulation (Low-Level Laser Therapy)","Other: Routine Physiotherapy Programme",{"label":16,"type":17,"description":18,"interventionNames":19},"Group B - Sham PBM + Routine PT","SHAM_COMPARATOR","Identical procedure using a deactivated PBM device (confirmed output \\\u003C1 mW by calibrated power meter). Same probe, contact time, and positioning as Group A. Combined with identical routine physiotherapy (wrist splinting + nerve gliding exercises).",[20,14],"Device: Sham Photobiomodulation",[22,32,37],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DEVICE","Photobiomodulation (Low-Level Laser Therapy)","Photobiomodulation (PBM) delivered using a 46-diode cluster probe at 830 nm wavelength, 200 mW optical output power, continuous wave mode, 4 J\u002Fcm² energy density, applied in static contact technique over the carpal tunnel (volar wrist surface, 3-5 cm proximal to distal wrist crease). Application time per session: approximately 200 seconds (\\~3.3 minutes). Treatment schedule: 3 sessions per week for 4 consecutive weeks (12 sessions total). Sham device output confirmed \\\u003C1 mW by calibrated photodiode power meter.",[9],[28,29,30,31],"Low-Level Laser Therapy","LLLT","Low-Level Light Therapy","PBMT",{"type":23,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"Sham Photobiomodulation","Deactivated PBM device identical in external appearance to the active device. Applied using the same 46-diode cluster probe, contact technique, and duration (approximately 200 seconds) as the active arm. Output power confirmed \\\u003C1 mW by calibrated photodiode power meter (LaserCheck or equivalent) at baseline, session 6, and session 12 for the first five enrolled participants. No therapeutic light emission occurs.",[16],null,{"type":6,"name":38,"description":39,"armGroupLabels":40,"otherNames":41},"Routine Physiotherapy Programme","Participants will receive an 4-week routine physiotherapy programme comprising median nerve mobilization, night splinting, and tendon-gliding exercises. Median nerve mobilization will use six sequential positions progressing from wrist-neutral finger\u002Fthumb flexion to finger, wrist, and thumb extension, forearm supination, and assisted thumb stretching. Each position will be held for 5 seconds; the sequence will be repeated 10 times, three times daily. A neutral volar wrist splint allowing free finger and thumb movement will be worn nightly for 6-8 hours. Tendon-gliding exercises will include straight hand, hook fist, full fist, tabletop, and straight fist positions. Each position will be held for 5 seconds, with 10 repetitions performed three times daily. A physiotherapist will teach and monitor the programme. Participants will receive illustrated instructions and maintain an adherence diary. Exercises will be modified or stopped if symptoms worsen.",[9,16],[42,43,44],"Multimodal Physiotherapy Programme","Conventional Physiotherapy","Standard Conservative Physiotherapy",[46,49,52,55],{"name":47,"affiliation":5,"role":48},"Dr Sajid Mehmood, MS (OMPT)","PRINCIPAL_INVESTIGATOR",{"name":50,"affiliation":5,"role":51},"Dr Ashfaq Ahmad, PhD","STUDY_DIRECTOR",{"name":53,"affiliation":5,"role":54},"Dr Umair Ahmed, PhD","STUDY_CHAIR",{"name":56,"affiliation":5,"role":54},"Dr Ishaq Ahmed, PhD",[58,63],{"name":59,"role":60,"phone":61,"phoneExt":36,"email":62},"Sajid Mehmood, MS (OMPT)","CONTACT","923218486974","drmsajidphy@gmail.com",{"name":50,"role":60,"phone":64,"phoneExt":36,"email":65},"923009449192","ashfaq.ahmad@uipt.uol.edu.pk",[67],{"facility":68,"status":36,"city":69,"state":70,"zip":71,"country":72,"countryCode":73,"cosmosGeoPoint":74,"geoPoint":79,"contacts":80},"University of Lahore Hospital","Lahore","Punjab Province","54000","Pakistan","PK",{"type":75,"coordinates":76},"Point",[77,78],74.35071,31.558,{"lat":78,"lon":77},[81,85,89],{"name":82,"role":60,"phone":83,"phoneExt":36,"email":84},"umair ahmed, PhD","00923212700817","umair.ahmed@uipt.uol.edu.pk",{"name":86,"role":60,"phone":87,"phoneExt":36,"email":88},"Dr Ishaq Ahmad, PhD","923344066463","ishaq.ahmad@uipt.uol.edu.pk",{"name":47,"role":48,"phone":36,"phoneExt":36,"email":36},{"type":91,"investigatorFullName":36,"investigatorTitle":36,"investigatorAffiliation":36,"oldNameTitle":36,"oldOrganization":36},"SPONSOR","100647811","photobiomodulation-for-median-nerve-neuroplasticity-in-carpal-tunnel-syndrome-a-randomized-controlled-trial-100647811",false,"NCT07714720","Photobiomodulation for Median Nerve Neuroplasticity in Carpal Tunnel Syndrome: A Randomized Controlled Trial","Therapeutic Effects of Photobiomodulation (Low Level Laser Therapy) on Median Nerve Neuroplasticity in Patients With Carpal Tunnel Syndrome","PBM-CTS-RCT","Inclusion criteria\n\n* Age 18-60 years\n* Clinical diagnosis of unilateral mild-to-moderate carpal tunnel syndrome based on positive Phalen test and\u002For Tinel sign\n* Electrophysiological confirmation of CTS via nerve conduction study (NCS) meeting AANEM 2012 diagnostic criteria for mild-to-moderate CTS\n* No prior photobiomodulation or laser therapy to the affected wrist within the preceding 3 months\n* Ability to attend 3 treatment sessions per week for 4 consecutive weeks\n* Able and willing to provide written informed consent (in Urdu or English)\n\nExclusion Criteria\n\n* Bilateral carpal tunnel syndrome\n* Previous surgical release of the carpal tunnel on the affected side\n* Systemic peripheral neuropathy (e.g., diabetes mellitus, hypothyroidism, Charcot-Marie-Tooth disease)\n* Pregnancy or breastfeeding\n* Implanted cardiac pacemaker, defibrillator, or other active electronic implant\n* Active malignancy at or near the treatment site\n* Current use of photosensitising medications (e.g., tetracyclines, amiodarone, psoralens)\n* Corticosteroid injection into the carpal tunnel within the preceding 3 months\n* Rheumatoid arthritis or other inflammatory joint disease affecting the wrist\n* Open wounds, acute skin infection, or tattooed skin at the treatment site\n* Inability to attend 3 sessions per week for 4 weeks\n* Severe CTS confirmed by NCS (complete sensory or motor axon loss)","ALL","18 Years","60 Years",{"count":104,"type":105},70,"ESTIMATED","INTERVENTIONAL",[108],"NA","Carpal Tunnel Syndrome (CTS) is the most common peripheral entrapment neuropathy, causing pain, paresthesia, and hand dysfunction due to median nerve compression at the wrist. While physiotherapy provides symptom relief, it does not effectively address the underlying neuroplastic deficits of the median nerve. Photobiomodulation (PBM), delivered at 830 nm near-infrared wavelength, has shown potential to enhance peripheral nerve regeneration via cytochrome c oxidase activation, ATP synthesis, and upregulation of neurotrophic factors including brain-derived neurotrophic factor (BDNF). This randomized controlled trial will evaluate whether 830 nm PBM (200 mW, 4 J\u002Fcm², 12 sessions over 4 weeks) combined with routine physiotherapy produces significantly greater neuroplastic recovery of the median nerve - assessed by high-resolution ultrasound (HRUS) measurement of median nerve cross-sectional area (CSA), nerve conduction study parameters and serum BDNF - compared to sham PBM combined with identical physiotherapy in adults with mild-to-moderate CTS. Neuroplasticity was operationalised as a multimodal construct comprising: (1) functional recovery, indexed by nerve conduction study parameters; (2) structural remodelling, indexed by median nerve cross-sectional area on high-resolution ultrasound; and (3) molecular neuroplastic signalling, indexed by serum BDNF. This multimodal approach was adopted because no single measure captures the full construct of peripheral nerve neuroplasticity (Padua et al., 2020).",[111],"Carpal Tunnel Syndrome (CTS)",[113,114,115,30,116,117,118,119,120,121],"Photobiomodulation","Median Nerve","Randomized Controlled Trial","Brain-Derived Neurotrophic Factor","Ultrasonography","Physical Therapy Modalities","Neuronal Plasticity","Carpal Tunnel Syndrome","Nerve Conduction Studies","NOT_YET_RECRUITING","2026-07-15",{"date":125,"type":126},"2026-07-20","ACTUAL",{"date":128,"type":105},"2026-08-15",{"date":130,"type":105},"2027-08-15",{"name":5,"class":6},1]