[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100653699":3},{"organization":4,"outcomesModule":7,"designInfo":18,"detailedDescription":21,"studyPopulation":22,"armGroups":23,"interventions":29,"overallOfficials":35,"centralContacts":40,"locations":49,"responsibleParty":67,"collaborators":11,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":77,"maxAge":11,"enrollmentInfo":78,"targetDuration":11,"studyType":81,"phases":11,"briefSummary":82,"conditions":83,"keywords":94,"overallStatus":52,"whyStopped":11,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Istituto Clinico Humanitas","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"Reduction of unclassifiable ILD diagnosis after MDD comparing PCDCT vs standard Chest HRCT scan using McNemar test",null,"2 years",[14,16],{"measure":15,"description":11,"timeFrame":12},"Increase in IPF diagnosis after MDD comparing PCDCT vs standard Chest HRCT scan using McNemar test",{"measure":17,"description":11,"timeFrame":12},"Interobserver agreement among radiologists using Cohen's kappa",{"allocation":11,"interventionModel":11,"interventionModelDescription":11,"primaryPurpose":11,"observationalModel":19,"timePerspective":20,"maskingInfo":11},"COHORT","PROSPECTIVE","The advent of a new generation of CT systems based on photon-counting detector technology is raising great interest in the medical community, anticipating a major improvement in numerous clinical applications including chest disorders. These expectations are drawn from the technological advantages inherent to these new CT systems, including a higher contrast-to-noise ratio, higher spatial resolution, and lower radiation dose together with the potential of multienergy imaging.\n\nNon-contrast enhanced CT will be acquired in spectral ultra-high-resolution mode on a clinical dual-source photon-counting detector CT (PCDCT) (NAEOTOM Alpha, Siemens Healthineers AG, Forchheim, Germany). All scans will be acquired with automated exposure control.\n\nRecent evidence showed that images obtained with PCDCT allowed a more precise depiction of CT features of ILDs with similar radiation dose. Subjective visualization of specific IPF features, such as reticulation and traction bronchiectasis, using PCDCT has been rated superior to conventional HRCT. Thus, a more precise delineation of fine fibrotic abnormalities could modify the categorization of ILD patterns and improve the diagnostic confidence of IPF and not-IPF diagnosis, reducing the prevalence of unclassifiable ILD.","Adults patients with a new diagnosis of ILD referred to the outpatient clinic of ILD of Humanitas Research Hospital, Rozzano - Milano) and with the need of a MDD discussion to reach a diagnosis will be enrolled.\n\nMDD will be leaded by two pulmonologists with 5 years of experience in ILDs. Each MDD session will include at least one additional pulmonologist, two thoracic radiologists, one thoracic surgeon, one thoracic pathologist, one rheumatologist, and at least two fellows in respiratory medicine. MDD meetings will be held every week and lasted approximately 60 minutes.\n\nPatients will be discussed using a standard case report form. Two diagnosis will be collected: the first diagnosis will be collected using the HRCT scan imaging. The second diagnosis will be collected using the PCDCT scan imaging.",[24],{"label":25,"type":11,"description":26,"interventionNames":27},"ILD patients undergoing radiological evaluation","Eligible partecipants will be adults (≥ 18 years of age) with a new diagnosis of ILD referred to the outpatient clinic of ILD of Humanitas Research Hospital, Rozzano - Milano) and with the need of a MDD discussion to reach a diagnosis.",[28],"Diagnostic Test: Photon counting CT",[30],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":11},"DIAGNOSTIC_TEST","Photon counting CT","Non-contrast enhanced CT will be acquired in spectral ultra-high-resolution mode on a clinical dual-source photon-counting detector CT (PCDCT) (NAEOTOM Alpha, Siemens Healthineers AG, Forchheim, Germany). All scans will be acquired with automated exposure control.",[25],[36],{"name":37,"affiliation":38,"role":39},"Francesco Amati, MD","Humanitas Research Hospital IRCCS, Rozzano-Milan","PRINCIPAL_INVESTIGATOR",[41,45],{"name":37,"role":42,"phone":43,"phoneExt":11,"email":44},"CONTACT","+393282592750","franesco.amati@hunimed.eu",{"name":46,"role":42,"phone":47,"phoneExt":11,"email":48},"Lisa Usuelli, MD","+393400095239","lisa.usuelli@humanitas.it",[50],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":54,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Humanitas Research Hospital","RECRUITING","Rozzano","Italy","20089","IT",{"type":58,"coordinates":59},"Point",[60,61],9.1559,45.38193,{"lat":61,"lon":60},[64,66],{"name":37,"role":42,"phone":43,"phoneExt":11,"email":65},"francesco.amati@hunimed.eu",{"name":46,"role":42,"phone":47,"phoneExt":11,"email":48},{"type":68,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100653699","photon-counting-ct-scan-vs-standard-hrct-scan-in-the-identification-of-idiopathic-pulmonary-fibrosis-100653699",false,"NCT07790614","Photon-counting CT Scan vs Standard HRCT Scan in the Identification of Idiopathic Pulmonary Fibrosis","CT-IPF ANTHEM","Inclusion Criteria:\n\n* ≥ 18 years of age\n* Any gender\n* Any race\n* Signed informed consent\n* ILD diagnosis with the need for a multidisciplinary discussion\n\nExclusion Criteria:\n\n* Patients with acute exacerbation of ILD\n* Interstitial abnormalities that could be explained by causes different than ILD (e.g.: heart failure; viral)","ALL","18 Years",{"count":79,"type":80},156,"ESTIMATED","OBSERVATIONAL","The CT-IPF ANTHEM study is designed to prospectively compare PCDCT to HRCT scan in the identification of specific ILD diagnosis discussed during the multidisciplinary discussion to increase diagnostic confidence and reduce unclassifiable ILD cases.",[84,85,86,87,88,89,90,91,92,93],"IPF","ILD","Interstitial Lung Disease (ILD)","Interstitial Lung Diseases","Idiopathic Pulmonary Fibrosis","Idiopathic Pulmonary Fibrosis (IPF)","CT Photon-Counting","CT Scan","CT","Interstitial Lung Disease Due to Systemic Disease (Telomere Biology Disorder)",[84,95,96,85,32,97,98,99],"Idiopathic pulmonary fibrosis","Interstitial lung diseases","CT scan","HRCT","PCDCT","2026-08-25",{"date":102,"type":103},"2026-08-27","ACTUAL",{"date":105,"type":103},"2025-03-25",{"date":107,"type":80},"2026-12",{"name":5,"class":6},1]