[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649060":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":50,"collaborators":17,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":55,"sex":61,"minAge":62,"maxAge":17,"enrollmentInfo":63,"targetDuration":17,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":76,"whyStopped":17,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"University of Illinois at Chicago","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment","EXPERIMENTAL","COM-B-based Physical Activity Behavior Intervention",[13],"Behavioral: COM-B-based Physical Activity Behavior Change Intervention",{"label":15,"type":16,"description":17,"interventionNames":17},"Waitlist Control","NO_INTERVENTION",null,[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":17},"BEHAVIORAL","COM-B-based Physical Activity Behavior Change Intervention","Participants will receive a remote-delivered physical activity program for 16 weeks that includes access to electronic newsletters and regular chats over Zoom with a behavioral coach:\n\nThe newsletters provide behavioral strategies such as information on the benefits of physical activity, goal setting and monitoring, for increasing and maintaining physical activity levels.\n\nThroughout the 16-week period, the investigators will ask participants to wear a Fitbit and record step count into a logbook daily for tracking physical activity.\n\nThe newsletter will be emailed to participants weekly throughout the program. The newsletters include knowledge, skills, and resources related to physical activity in the early stages of MS.\n\nThe program also involves 7 1-on-1 coaching chats with a coach to guide participants through the program and navigate challenges. These chats are conducted over Zoom and generally last about 15 - 30 minutes each. These sessions will not be recorded.",[9],[25],{"name":26,"affiliation":5,"role":27},"Robert Motl, PhD","PRINCIPAL_INVESTIGATOR",[29],{"name":30,"role":31,"phone":32,"phoneExt":17,"email":33},"Lexi Huynh, PhD","CONTACT","312-996-6615","activnms@uic.edu",[35],{"facility":36,"status":17,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"University of Illinois Chicago","Chicago","Illinois","60612","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-87.65005,41.85003,{"lat":46,"lon":45},[49],{"name":30,"role":31,"phone":32,"phoneExt":17,"email":33},{"type":27,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":17,"oldOrganization":17},"Robert W Motl","Principal Investigator","100649060","physical-activity-intervention-for-individuals-newly-diagnosed-with-ms-100649060",false,"NCT07731659","Physical Activity Intervention for Individuals Newly Diagnosed With MS","Physical Activity Behavior Change Intervention in Persons Newly Diagnosed With Multiple Sclerosis - ActivNMS Trial - COM-B Construct Testing","ActivNMS","Inclusion Criteria:\n\n* aged 18 years or older\n* self-reported diagnosis of MS by a neurologist within the past 2 years\n* relapse-free for the past 30 days\n* ability to speak and read English as the primary language\n* internet and e-mail access\n* willingness to complete study protocol\n* ambulatory without an assistive device (PDDS \\\u003C 3)\n* insufficiently active (Godin Leisure-Time Exercise Questionnaire (GLTEQ) \\\u003C 14)\n* visual ability and literacy to read newsletter with font size 14 points\n* on a stable disease-modifying therapy for 6 months\n\nExclusion Criteria:\n\n* pregnant\n* have an elevated risk for undertaking strenuous or maximal exercise based on two or more affirmatives on the Physical Activity Readiness Questionnaire (PAR-Q)","ALL","18 Years",{"count":64,"type":65},50,"ESTIMATED","INTERVENTIONAL",[68],"NA","The proposed study is a parallel-group randomized controlled trial (RCT) designed to establish the behavioral mechanism underlying a 16-week physical activity (PA) behavioral intervention through its effects on the Capability-Opportunity-Motivation-Behavior (COM-B) constructs. The success of this study will provide robust evidence for supporting its refinement via refined COM-B constructs and Behavior Change Techniques to facilitate or maximize the intervention effects on PA levels, which will be examined in the subsequent clinical trial. Such an approach will involve an RCT that examines the effects of a 16-week remotely delivered, Internet-based PA behavioral intervention via video behavioral coaching and newsletter compared with a waitlist control (WLC) condition for yielding improvements in the COM-B constructs among persons newly diagnosed with multiple sclerosis (PNDwMS, disease duration ≤ 2 years). The investigators hypothesize that participants in the PA behavioral intervention condition will demonstrate greater improvements in the COM-B constructs than those in the WLC condition. The investigators plan to recruit 50 PNDwMS, with a distribution of 25 participants in the PA behavioral intervention and 25 participants in the WLC condition. The primary outcomes are the self-report COM-B constructs (listed in the Outcomes section), which will be remotely assessed at baseline and post-intervention through an online battery of questionnaires via REDCap.\n\nSpecific Aim 1: to establish mechanisms for the behavior change intervention using a 2-arm pilot randomized controlled trial (RCT) of the intervention compared with the waitlist control (WLC) among PNDwMS. The investigators hypothesize that the 16-week COM-B-based behavioral intervention delivered by one-on-one behavior coaching and newsletters will result in larger changes in COM-B constructs (i.e., knowledge, outcome expectations, goal, intention, behavioral regulation, self-efficacy, fatigue, social support, and social and environmental barriers) than in the WLC group.\n\nSpecific Aim 2: to examine change in self-reported physical activity levels in PNDwMS who received the COM-B-based intervention compared with those who are in the waitlist control condition. The investigators hypothesize that the 16-week COM-B-based behavioral intervention will result in larger changes in self-reported physical activity outcomes than in the WLC group.",[71],"Multiple Sclerosis",[73,74,75],"Physical Activity","Newly Diagnosed MS","Behavioral Intervention","NOT_YET_RECRUITING","2026-07-25",{"date":79,"type":80},"2026-07-28","ACTUAL",{"date":82,"type":65},"2026-10-01",{"date":84,"type":65},"2028-10-01",{"name":5,"class":6},1]