[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100559178":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":36,"responsibleParty":53,"collaborators":18,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":18,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":18,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":38,"whyStopped":18,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"University of Sao Paulo","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Group","EXPERIMENTAL","The experimental group will be submitted to supervised training sessions, three times per week, for 12 weeks, of aerobics exercises, as well as treatment as usual (TAU)",[13],"Other: Physical Exercise",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group","NO_INTERVENTION","the control group will be submitted exclusively to treatment as usual (TAU)",null,[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":18},"Physical Exercise","Measure the impact of physical exercise in the cognition of pacients diagnosed with Bipolar Disorder",[9],[25],{"name":26,"affiliation":5,"role":27},"Beny Lafer, M.D, Ph.D","PRINCIPAL_INVESTIGATOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":18,"email":33},"Gabriel Okawa Belizario","CONTACT","+55 (11) 963391570","gabrielokawabelizario@gmail.com",{"name":26,"role":31,"phone":18,"phoneExt":18,"email":35},"benylafer@gmail.com",[37],{"facility":30,"status":38,"city":39,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"RECRUITING","São Paulo","05403-903","Brazil","BR",{"type":44,"coordinates":45},"Point",[46,47],-46.63611,-23.5475,{"lat":47,"lon":46},[50],{"name":51,"role":31,"phone":52,"phoneExt":18,"email":33},"Gabriel Belizario","+55 (11)963391570",{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"SPONSOR_INVESTIGATOR","Beny Lafer","Principal INvestigator","100559178","physical-exercise-for-cognitive-rehabilitation-of-patients-with-bipolar-affective-disorder-100559178",false,"NCT06560749","Physical Exercise for Cognitive Rehabilitation of Patients With Bipolar Affective Disorder","Physical Exercise for Cognitive Rehabilitation of Patients With Bipolar Affective Disorder: a Controlled and Randomized Study","Inclusion Criteria:\n\n* Diagnosis of Bipolar disorder (BD) I and II according to DSM-5\n* Age: 18 - 55 years old\n* Complete primary education\n* Euthymic (YMRS \\\u003C 8 and MADRS \\\u003C 12)\n* Presence of cognitive impairments (COBRA \\> 14 and SCIP \\\u003C 75)\n* Estimated IQ ≥ 80\n* No medication changes in the last month\n* Having been without regular PE practice for six months\n* Signature of the TCLE\n\nExclusion Criteria:\n\n* Organic mental disorder\n* BMI \\> 40\n* Alcohol or drug abuse in the last 6 months\n* Use of benzodiazepines or beta-blockers in the last month","ALL","18 Years","60 Years",{"count":68,"type":69},72,"ESTIMATED","INTERVENTIONAL",[72],"NA","The goal of this clinical trial is to evaluate the impact of Physical Exercise (PE), as an adjuvant treatment, on the cognition of patients diagnosed with Bipolar Disorder who present cognitive impairments, as well as its impact on quality of life and functionality and its association with physiological variables.\n\nOur specific goals are:\n\n1. Evaluate the effect of PE on the neuropsychological functions of attention, memory, verbal fluency, executive function and processing speed in patients diagnosed with BD who present cognitive impairments in these domains.\n2. To evaluate the effect of PE on the quality of life and functionality of patients diagnosed with BD, as well as possible associations with cognitive functions.\n3. To evaluate possible correlations between physiological variables, such as cardiorespiratory indices, strength and body composition, and improvements in cognitive functions, quality of life and functionality.",[75],"Bipolar Disorder",[75],"2026-07-14",{"date":79,"type":80},"2026-07-16","ACTUAL",{"date":82,"type":80},"2024-08-20",{"date":84,"type":69},"2027-09",{"name":55,"class":6},1]