[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100191738":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":17,"studyPopulation":18,"armGroups":19,"interventions":25,"overallOfficials":31,"centralContacts":36,"locations":45,"responsibleParty":67,"collaborators":70,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":13,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":82,"minAge":13,"maxAge":13,"enrollmentInfo":83,"targetDuration":13,"studyType":86,"phases":13,"briefSummary":87,"conditions":88,"keywords":13,"overallStatus":48,"whyStopped":13,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University of California, Irvine","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"high-resolution images of skin","The complementary imaging modalities (MPM, MI) will provide insights into a better understanding of the relationship between microscopic and macroscopic properties of the skin.","up to 12 months",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":16,"maskingInfo":13},"CASE_ONLY","RETROSPECTIVE","This study is performed using a multiphoton microscopy-based tomograph (MPTflex) developed by JenLab, GmbH (Germany) and a MPM imaging system developed at BLI: Fast Large Area Multiphoton Exoscope (FLAME) to image non-invasively normal and lesional skin. Skin lesions are imaged by multiphoton microscopy and images are compared to those obtained from histopathology through standard of care processed skin biopsies.\n\nAny biopsies will be performed by the health care provider as a standard of care procedure.","Study population will be selected from University of California Irvine Medical Clinic",[20],{"label":21,"type":13,"description":22,"interventionNames":23},"Human skin","Multiphoton microscopy imaging to collect information about changes in skin cells and fibrilar structure.",[24],"Device: Multiphoton microscopy-based tomograph.",[26],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":13},"DEVICE","Multiphoton microscopy-based tomograph.","non-invasive optical biopsy",[21],[32],{"name":33,"affiliation":34,"role":35},"Kristen Kelly, MD","Beckman Laser Institute, UCI","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":13,"email":41},"Hanna Kim","CONTACT","949-824-2251","hhkim3@uci.edu",{"name":43,"role":39,"phone":13,"phoneExt":13,"email":44},"Mihaela Balu, PhD","mbalu@uci.edu",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Beckman Laser Institute Medical Clinic","RECRUITING","Irvine","California","92612","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-117.82311,33.66946,{"lat":58,"lon":57},[61,62,63,65],{"name":38,"role":39,"phone":40,"phoneExt":13,"email":41},{"name":33,"role":35,"phone":13,"phoneExt":13,"email":13},{"name":43,"role":64,"phone":13,"phoneExt":13,"email":13},"SUB_INVESTIGATOR",{"name":66,"role":64,"phone":13,"phoneExt":13,"email":13},"Kenneth Linden, MD PhD",{"type":35,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"Kristen Kelly","Professor and Chair, Department of Dermatology",[71],{"name":72,"class":73},"National Institute for Biomedical Imaging and Bioengineering (NIBIB)","NIH","100191738","pilot-study-on-in-vivo-non-invasive-skin-imaging-using-multiphoton-microscopy-100191738",false,"NCT01771718","Pilot Study on In-vivo Non-invasive Skin Imaging Using Multiphoton Microscopy","Non-invasive Skin Imaging Using Multiphoton Microscopy","Inclusion Criteria:\n\n* Male or Female all age groups\n* Ability to understand and carry out subject instructions\n\nExclusion Criteria:\n\n* Pregnant women",true,"ALL",{"count":84,"type":85},250,"ESTIMATED","OBSERVATIONAL","The purpose of this pilot study is to employ multiphoton microscopy to non-invasively image in-vivo pigmented and non-pigmented human skin lesions for characterization of their morphologic and functional features.",[89],"Skin Lesion","2026-08-26",{"date":92,"type":93},"2026-08-31","ACTUAL",{"date":95,"type":13},"2012-04",{"date":97,"type":85},"2028-12",{"name":5,"class":6},1]