[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649190":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":24,"locations":24,"responsibleParty":29,"collaborators":24,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":24,"eligibilityCriteria":39,"healthyVolunteers":35,"sex":40,"minAge":41,"maxAge":24,"enrollmentInfo":42,"targetDuration":24,"studyType":45,"phases":46,"briefSummary":48,"conditions":49,"keywords":24,"overallStatus":51,"whyStopped":24,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":24},{"fullName":5,"class":6},"University of Health Sciences Lahore","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A: MVA Cannula","ACTIVE_COMPARATOR","Participants assigned to Group A will undergo endometrial tissue sampling using a 4 mm Manual Vacuum Aspiration (MVA) cannula attached to an aspiration syringe without local anesthesia or cervical dilation under aseptic conditions.",[13],"Other: Manual Vacuum Aspiration (MVA) Cannula",{"label":15,"type":10,"description":16,"interventionNames":17},"Group B: Pipelle Biopsy","Participants assigned to Group B will undergo endometrial sampling using a standard Pipelle device under aseptic conditions without local anesthesia or cervical dilation. The piston will be withdrawn to create vacuum-assisted suction and rotated to acquire tissue.",[18],"Other: Pipelle Endometrial Suction Curette",[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Manual Vacuum Aspiration (MVA) Cannula","Endometrial sampling using a 4 mm flexible polyethylene MVA cannula connected to a manual vacuum aspiration syringe without dilation or anesthesia.",[9],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Pipelle Endometrial Suction Curette","Endometrial biopsy using a flexible Pipelle device operated by pulling the internal piston to create negative pressure without dilation or anesthesia.",[15],{"type":30,"investigatorFullName":31,"investigatorTitle":32,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","DR. IZAM AFZAL","Principle Investigator","100649190","pipelle-versus-manual-vacuum-aspiration-cannula-for-endometrial-biopsy-in-women-with-abnormal-uterine-bleeding-100649190",false,"NCT07731581","Pipelle Versus Manual Vacuum Aspiration Cannula for Endometrial Biopsy in Women With Abnormal Uterine Bleeding","A Comparative Study of Pipelle Versus Manual Vacuum Aspiration Cannula for Endometrial Biopsy","Inclusion Criteria:\n\n1. Married women aged 35 years and above.\n2. Presentation with abnormal uterine bleeding (AUB), including but not limited to metrorrhagia, menorrhagia, or postmenopausal bleeding.\n3. Clinical indication for endometrial sampling for diagnostic evaluation of abnormal uterine bleeding.\n4. Patient fit for both MVA and Pipelle procedures, with no contraindications to either method.\n\nExclusion Criteria:\n\n1. Pregnancy or suspicion of pregnancy.\n2. Acute pelvic inflammatory disease or active genital tract infection.\n3. Current use of anticoagulant therapy or presence of bleeding disorders that pose a risk for excessive bleeding during endometrial sampling.","FEMALE","35 Years",{"count":43,"type":44},80,"ESTIMATED","INTERVENTIONAL",[47],"NA","women globally, often requiring endometrial tissue sampling for accurate evaluation and diagnosis. Traditional office-based sampling techniques like Pipelle are widely used, but the disposable instruments can be relatively expensive in resource-limited settings. Manual Vacuum Aspiration (MVA) using a flexible cannula is an inexpensive, reusable alternative, but clinical data comparing its performance directly to Pipelle remains limited.\n\nThe objective of this randomized clinical trial is to compare Pipelle endometrial biopsy and Manual Vacuum Aspiration (MVA) cannula in terms of sample adequacy, patient satisfaction, and post-procedure complications in women presenting with abnormal uterine bleeding. Participants will be randomly assigned to undergo endometrial sampling using either a 4 mm MVA cannula or a Pipelle device without anesthesia or cervical dilation. Samples will be analyzed for histopathological diagnosis, and outcomes such as procedure pain, adequacy of tissue, and complications will be recorded.",[50],"Abnormal Uterine Bleeding (AUB)","NOT_YET_RECRUITING","2026-07-22",{"date":54,"type":55},"2026-07-28","ACTUAL",{"date":57,"type":44},"2026-08-11",{"date":59,"type":44},"2027-08-12",{"name":5,"class":6}]