[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650804":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":13,"locations":19,"responsibleParty":36,"collaborators":7,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":7,"eligibilityCriteria":44,"healthyVolunteers":40,"sex":45,"minAge":46,"maxAge":47,"enrollmentInfo":48,"targetDuration":7,"studyType":51,"phases":7,"briefSummary":52,"conditions":53,"keywords":7,"overallStatus":56,"whyStopped":7,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":66},{"fullName":5,"class":6},"Institute of Hematology & Blood Diseases Hospital, China","OTHER",null,[9],{"name":10,"affiliation":11,"role":12},"Xiaofan Zhu, MD","Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC","PRINCIPAL_INVESTIGATOR",[14],{"name":15,"role":16,"phone":17,"phoneExt":7,"email":18},"Lipeng Liu, MD","CONTACT","86-22-23909336","liulipeng@ihcams.ac.cn",[20],{"facility":21,"status":7,"city":22,"state":23,"zip":24,"country":25,"countryCode":26,"cosmosGeoPoint":27,"geoPoint":32,"contacts":33},"Department of Pediatric Hematology\u002FOncology,Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences","Tianjin","Tianjin Municipality","300020","China","CN",{"type":28,"coordinates":29},"Point",[30,31],117.17667,39.14222,{"lat":31,"lon":30},[34],{"name":15,"role":16,"phone":35,"phoneExt":7,"email":18},"+86 22 2390919",{"type":37,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100650804","plasma-ctdna-monitoring-in-pediatric-acute-leukemia-100650804",false,"NCT07751588","Plasma ctDNA Monitoring in Pediatric Acute Leukemia","A Retrospective-Prospective Observational Cohort Study of Peripheral Blood Plasma ctDNA Compared With Bone Marrow MFC-MRD, ddPCR, and RNA Sequencing in Pediatric Acute Leukemia","Inclusion Criteria:\n\n1. Patients diagnosed with pediatric acute leukemia, including acute lymphoblastic leukemia, acute myeloid leukemia, or mixed phenotype acute leukemia.\n2. Age younger than 18 years at diagnosis.\n3. Availability of peripheral blood plasma cfDNA\u002FctDNA testing data.\n4. Availability of clinical data and at least one corresponding bone marrow-based assessment, including MFC-MRD, ddPCR, RNA sequencing.\n5. For prospectively collected follow-up data or samples, written informed consent will be obtained from parents or legal guardians.\n6. For retrospectively collected data, consent procedures will follow the approval of the institutional ethics committee.\n\nExclusion Criteria:\n\n1. Patients without available peripheral blood plasma cfDNA\u002FctDNA data.\n2. Patients with insufficient clinical or laboratory data for analysis.\n3. Samples failing cfDNA\u002FctDNA quality control.\n4. Withdrawal of consent for prospective follow-up or additional sample collection.\n5. Patients judged by the investigator to be unsuitable for inclusion.","ALL","3 Years","18 Years",{"count":49,"type":50},25,"ESTIMATED","OBSERVATIONAL","This retrospective-prospective observational cohort study aims to evaluate peripheral blood plasma circulating tumor DNA (ctDNA) dynamics in pediatric acute leukemia and compare ctDNA results with concurrent bone marrow multiparameter flow cytometry minimal residual disease (MFC-MRD), droplet digital PCR (ddPCR), and RNA sequencing findings. The study includes a retrospective cohort with available clinical and molecular data and a prospective cohort with serially collected peripheral blood and bone marrow samples at predefined treatment time points. The study will assess consistence between plasma ctDNA and conventional bone marrow-based assays, characterize longitudinal ctDNA dynamics, and explore the association between ctDNA patterns and relapse or survival outcomes.",[54,55],"Acute Myeloid Leukemia","Acute Lymphoblastic Leukemia","NOT_YET_RECRUITING","2026-08-05",{"date":59,"type":60},"2026-08-07","ACTUAL",{"date":62,"type":50},"2026-07-11",{"date":64,"type":50},"2027-12-31",{"name":5,"class":6},1]