[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100659618":3},{"organization":4,"outcomesModule":7,"designInfo":22,"detailedDescription":32,"studyPopulation":21,"armGroups":33,"interventions":55,"overallOfficials":73,"centralContacts":79,"locations":85,"responsibleParty":101,"collaborators":21,"id":103,"slug":104,"hasResults":105,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":111,"sex":112,"minAge":113,"maxAge":114,"enrollmentInfo":115,"targetDuration":21,"studyType":118,"phases":119,"briefSummary":121,"conditions":122,"keywords":125,"overallStatus":130,"whyStopped":21,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":140},{"fullName":5,"class":6},"University of Virginia","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":21,"otherOutcomes":21},[9,13,17],{"measure":10,"description":11,"timeFrame":12},"Blood pressure (Central and Peripheral)","The central and peripheral blood pressures will be measured using a validated automated system (Oscar 2 (SunTech)\u002F SphygmoCor system (Atcor Medical). This system processes brachial waveforms using dedicated software with a validated generalized transfer function to derive a corresponding aortic pressure waveform. Aortic waveforms are then further processed to identify systolic (SBP in mmHg), mean (MAP in mmHg), diastolic (DBP in mmHg), and pulse pressure (PP in mmHg). This allows calculation of augmentation pressure (AugP in mmHg) (due to wave reflection) and the augmentation index (AIx = (AugP\u002FPP) × 100) in percentage units. Participants will sit for at least 15 minutes before each measurement.","Before each condition and after every 15 minutes for 3 hours.",{"measure":14,"description":15,"timeFrame":16},"Impedance Cardiography","Measure of central hemodynamics (cardiac output (L\u002Fmin), stroke volume (mL), and systemic vascular resistance (dyn.s.cm5) etc.) will be non-invasively captured using the PhysioFlow Q-Link System. This system uses electrodes placed on the participant's body and applies the principles of signal-morphology impedance cardiography to estimate central cardiac measures at rest and after exercise.","Before, during, and after (upto 3 hours post every 15 min) each condition",{"measure":18,"description":19,"timeFrame":20},"Plasma\u002FSaliva Nitrate and Nitrate","Plasma\u002FSaliva samples will be collected to assess changes in plasma\u002Fsaliva nitrate (measured in micromolar- uM) and nitrite (measured in nanomolar- nM) following either BRJ or placebo and in different exercise and control conditions.","Before and after 2 hours post supplementation of BRJ, Placebo",null,{"allocation":23,"interventionModel":24,"interventionModelDescription":21,"primaryPurpose":6,"observationalModel":21,"timePerspective":21,"maskingInfo":25},"RANDOMIZED","CROSSOVER",{"masking":26,"maskingDescription":21,"whoMasked":27},"QUADRUPLE",[28,29,30,31],"PARTICIPANT","CARE_PROVIDER","INVESTIGATOR","OUTCOMES_ASSESSOR","Inorganic nitrate supplementation (NS) has gained popularity since the early 2010s as a means to improve exercise performance. The benefits of NS include, but are not limited to, improved exercise tolerance, reduced resting peripheral blood pressure, and improved vascular health. However, the post-exercise hypotension (PEH) effects of NS remain poorly understood, primarily due to poorly controlled studies with heterogeneous populations. NS has been shown to increase nitric oxide (NO) bioavailability (via the nitrate-nitrite-NO pathway), which is independent of endothelial NO synthase and may play a role in conferring additive vascular benefits when combined with acute exercise. Purpose: To assess the effects of NS supplementation on the magnitude of PEH following acute exercise compared to placebo. Methods: Twelve young adults with BMI ≥ 30 kg\u002Fm2 with central adiposity (defined by waist circumference of ≥ 94 cm for males, and 80cm for females), and elevated resting BP will participate in a double-blinded crossover design and receive acute exercise + beetroot juice, acute exercise + placebo, no exercise + beetroot juice, and no exercise + placebo. Results: The successful completion of this project will elucidate the role of NS on PEH response with acute exercise and its potential mechanisms.",[34,40,45,50],{"label":35,"type":36,"description":37,"interventionNames":38},"A","EXPERIMENTAL","1 x 4 crossover design where each participant will be randomized to complete four conditions after at least a 3-day washout period.",[39],"Dietary Supplement: Beetroot Juice - Active + Exercise",{"label":41,"type":42,"description":37,"interventionNames":43},"B","ACTIVE_COMPARATOR",[44],"Dietary Supplement: Beetroot juice placebo + Exercise",{"label":46,"type":47,"description":37,"interventionNames":48},"C","PLACEBO_COMPARATOR",[49],"Dietary Supplement: Beetroot Juice - Active + No exercise",{"label":51,"type":52,"description":37,"interventionNames":53},"D","SHAM_COMPARATOR",[54],"Dietary Supplement: Beetroot juice placebo+ No exercise",[56,61,65,69],{"type":57,"name":58,"description":59,"armGroupLabels":60,"otherNames":21},"DIETARY_SUPPLEMENT","Beetroot Juice - Active + Exercise","Supplement with 140 mL nitrate-rich beverage (800mg NO3-) (\\~12.9 mmol\u002FL) 1 hour 30 minutes before lab visit after a 3-day washout + ACUTE EXERCISE and post-exercise blood pressure, and central hemodynamics measured via impedance cardiography.",[35],{"type":57,"name":62,"description":63,"armGroupLabels":64,"otherNames":21},"Beetroot juice placebo + Exercise","Supplement with 140 mL nitrate-depleted beverage (\\\u003C0.1 mmol\u002FL) after a 3-day washout + ACUTE EXERCISE, and post-exercise blood pressure, and central hemodynamics measured via impedance cardiography",[41],{"type":57,"name":66,"description":67,"armGroupLabels":68,"otherNames":21},"Beetroot Juice - Active + No exercise","Supplement with 140mL nitrate rich beverage (800mg NO3-) (\\~12.9 mmol\u002FL) 1 hour 30 minutes before lab visit after a 3 day washout + NO EXERCISE, and blood pressure, and central hemodynamics measured via impedance cardiography.",[46],{"type":57,"name":70,"description":71,"armGroupLabels":72,"otherNames":21},"Beetroot juice placebo+ No exercise","Supplement with 140 mL nitrate-depleted beverage (\\\u003C0.1 mmol\u002FL) after a 3-day washout + NO EXERCISE, and blood pressure and central hemodynamics measured via impedance cardiography.",[51],[74,77],{"name":75,"affiliation":5,"role":76},"Jason Allen","PRINCIPAL_INVESTIGATOR",{"name":78,"affiliation":5,"role":76},"Siddhartha Angadi",[80],{"name":81,"role":82,"phone":83,"phoneExt":21,"email":84},"Money Ghimire, M.S","CONTACT","4349243004","eta8xd@uvahealth.org",[86],{"facility":5,"status":21,"city":87,"state":88,"zip":89,"country":90,"countryCode":91,"cosmosGeoPoint":92,"geoPoint":97,"contacts":98},"Charlottesville","Virginia","22903","United States","US",{"type":93,"coordinates":94},"Point",[95,96],-78.47668,38.02931,{"lat":96,"lon":95},[99],{"name":100,"role":82,"phone":83,"phoneExt":21,"email":84},"Money Ghimire, M.S.",{"type":76,"investigatorFullName":75,"investigatorTitle":102,"investigatorAffiliation":5,"oldNameTitle":21,"oldOrganization":21},"Professor","100659618","post-exercise-blood-pressure-with-inorganic-nitrate-100659618",false,"NCT07869472","Post-exercise Blood Pressure With Inorganic Nitrate","Effects of Inorganic Nitrate Supplementation on Post-exercise Hypotension Response Following Acute Exercise in Young Adults With Elevated Body Mass Index and Blood Pressure","BEET-DOWN","Inclusion Criteria:\n\n* Willingness and ability to comply with scheduled visits and study procedures.\n* Males and females, ages 18-40 years old\n* Sedentary (\\\u003C150 minutes of moderate intensity aerobic exercise per week, or not engaged in a regular exercise program at all\n* Resting systolic BP ≥ 120 mmHg.\n* BMI ≥ 30 kg\u002Fm2\n* Waist circumference ≥94 cm for males and ≥80 cm for females\n* Be able to perform exercise on a cycle ergometer without assistance\n* Stable medication regimen for the last 6 months\n* Be able to discontinue the use of inorganic nitrate rich foods such as beets, arugula, spinach, celery, and grapefruit throughout the duration of the study.\n\nExclusion Criteria:\n\n* Body mass index ≤ 29.9 Kg\u002Fm2\n* Smoker within last 5 years\n* Has experienced significant weight loss \\~3 kg in the last three months or taking any weight loss drugs\n* Current medical condition that prohibits exercising at high intensities\n* Currently on hormone replacement of any kind\n* History of medical conditions that would prohibit high intensity exercise, such as:, uncontrolled hypertension (≥140\u002F90), diabetes, myocardial infarction, cerebrovascular event, known cardiovascular, pulmonary, renal, metabolic diseases, and acute or unstable disease other than high BMI and waist circumference\n* Current injuries that would prohibit exercising on a stationary bike\n* Currently restricted by medical doctor to engage in exercise\n* Currently taking or have taken any of the following medications in the last 4 weeks (calcium channel blockers, statins, ACE or renin inhibitors, angiotensin receptor blockers, organic nitrates (e.g., nitroglycerine, alpha- or beta-blockers, diuretics, proton pump inhibitors, PDE-5 inhibitors (e.g., Cialis, Viagra), or xanthine oxidase inhibitors (e.g., Allopurinol))\n* Oral antibiotic use within previous four weeks including over-the-counter antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use\n* Oral cancer\u002Fsevere oral disease\n* Had hysterectomy or oophorectomy\n* Pregnant women or planning to be pregnant, Fetuses, neonates, children, prisoners, cognitively impaired, non-English speaking participants",true,"ALL","18 Years","40 Years",{"count":116,"type":117},12,"ESTIMATED","INTERVENTIONAL",[120],"NA","This study is examining whether acute inorganic nitrate supplementation in the form of beetroot juice, paired with an acute bout of exercise, affects blood pressure and what is the magnitude of the difference compared to exercise alone.",[123,124],"Obese Individuals","Central Adiposity",[126,127,128,129],"obesity","central adiposity","elevated blood pressure","dietary nitrate","NOT_YET_RECRUITING","2026-10-06",{"date":133,"type":134},"2026-10-09","ACTUAL",{"date":136,"type":117},"2026-10-15",{"date":138,"type":117},"2027-03-30",{"name":5,"class":6},1]