[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100659800":3},{"organization":4,"outcomesModule":7,"designInfo":18,"detailedDescription":27,"studyPopulation":17,"armGroups":28,"interventions":50,"overallOfficials":64,"centralContacts":68,"locations":78,"responsibleParty":93,"collaborators":17,"id":97,"slug":98,"hasResults":99,"nctId":100,"briefTitle":101,"officialTitle":101,"acronym":17,"eligibilityCriteria":102,"healthyVolunteers":99,"sex":103,"minAge":104,"maxAge":105,"enrollmentInfo":106,"targetDuration":17,"studyType":109,"phases":110,"briefSummary":112,"conditions":113,"keywords":116,"overallStatus":81,"whyStopped":17,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":131},{"fullName":5,"class":6},"Istanbul Medipol University Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":17,"otherOutcomes":17},[9,13],{"measure":10,"description":11,"timeFrame":12},"Postoperative Pain","Postoperative pain following single-session primary root canal treatment, assessed using a 10-point visual analog scale (VAS), ranging from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. higher scores indicate greater pain intensity.","6 hours, 24 hours, 48 hours, 72 hours, 1 week, 1 month after root canal treatment.",{"measure":14,"description":15,"timeFrame":16},"Clinical Success and Radiographic Radiographic Changes in Periapical Lesion Size Following Root Canal Treatment","Radiographic assessment of periapical lesion size following single-session primary root canal treatment. Periapical lesion size will be measured on digital periapical radiographs using image analysis software. A coin of known diameter will be used as a radiographic calibration reference to standardize measurements. The maximum diameter of the periapical radiolucency will be measured in millimeters (mm) at each follow-up examination (1, 3, 6, and 12 months). Changes in lesion size will be calculated by comparing measurements obtained at baseline and subsequent follow-up examinations.","1 months \u002F 3 months \u002F6 months \u002F 12 months",null,{"allocation":19,"interventionModel":20,"interventionModelDescription":17,"primaryPurpose":21,"observationalModel":17,"timePerspective":17,"maskingInfo":22},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":23,"maskingDescription":17,"whoMasked":24},"DOUBLE",[25,26],"PARTICIPANT","CARE_PROVIDER","A total of 200 patients will be evaluated and divided into four treatment groups according to the root canal filling material and technique: AH Plus with warm gutta-percha, AH Plus with the single-cone technique, TotalFill BC Sealer with the single-cone technique, and One-Fil with the single-cone technique. Postoperative pain will be assessed, while periapical healing will be evaluated clinically and radiographically using the Periapical Index (PAI) during follow-up visits extending from 1 month to 1 year. The study aims to compare different root canal sealers and obturation techniques and contribute to the understanding of their long-term treatment outcomes.",[29,35,40,45],{"label":30,"type":31,"description":32,"interventionNames":33},"One Fill","EXPERIMENTAL","Root canal obturation using One Fill root canal sealer according to the manufacturer's instructions.",[34],"Other: One-Fill",{"label":36,"type":31,"description":37,"interventionNames":38},"TotalFill","Root canal obturation using TotalFill root canal sealer according to the manufacturer's instructions.",[39],"Other: TotalFill",{"label":41,"type":31,"description":42,"interventionNames":43},"AH Plus + Single Cone","Root canal obturation using AH Plus root canal sealer in combination with a single-cone obturation technique.",[44],"Other: AH Plus + Single Cone",{"label":46,"type":31,"description":47,"interventionNames":48},"AH Plus + Continuous Wave","Root canal obturation using AH Plus root canal sealer in combination with a continuous-wave obturation technique.",[49],"Other: AH Plus + Continuous Wave",[51,55,58,61],{"type":6,"name":52,"description":53,"armGroupLabels":54,"otherNames":17},"One-Fill","Root canal obturation using One-Fill bioceramic sealer with a single-cone technique. The prepared root canal is filled with a fitted gutta-percha cone coated with One-Fill sealer according to the manufacturer's instructions.",[30],{"type":6,"name":36,"description":56,"armGroupLabels":57,"otherNames":17},"Root canal obturation using TotalFill BC Sealer with a single-cone technique. The prepared root canal is filled with a fitted gutta-percha cone coated with TotalFill BC Sealer according to the manufacturer's instructions.",[36],{"type":6,"name":41,"description":59,"armGroupLabels":60,"otherNames":17},"Root canal obturation using AH Plus epoxy resin-based sealer with a single-cone technique. A fitted gutta-percha cone is coated with AH Plus sealer and placed to the working length according to the study protocol.",[41],{"type":6,"name":46,"description":62,"armGroupLabels":63,"otherNames":17},"Root canal obturation using AH Plus epoxy resin-based sealer with the continuous wave of condensation technique. The master gutta-percha cone is fitted to the working length, followed by down-pack and backfill procedures using heated gutta-percha according to the study protocol.",[46],[65],{"name":66,"affiliation":17,"role":67},"Tan Firat eyuboglu, Prof","STUDY_DIRECTOR",[69,74],{"name":70,"role":71,"phone":72,"phoneExt":17,"email":73},"omer albanki, DDS","CONTACT","00905365927496","omaralbanki1997@gmail.com",{"name":75,"role":71,"phone":76,"phoneExt":17,"email":77},"Yelda Erdem Hepsenoglu, PhD","00905054104563","yelda_erdem89@hotmail.com",[79],{"facility":80,"status":81,"city":82,"state":83,"zip":17,"country":84,"countryCode":17,"cosmosGeoPoint":85,"geoPoint":90,"contacts":91},"Istanbul Medipol University, Faculty of Dentistry","RECRUITING","Istanbul","Esenler","Turkey (Türkiye)",{"type":86,"coordinates":87},"Point",[88,89],28.94966,41.01384,{"lat":89,"lon":88},[92],{"name":75,"role":71,"phone":76,"phoneExt":17,"email":77},{"type":94,"investigatorFullName":95,"investigatorTitle":96,"investigatorAffiliation":5,"oldNameTitle":17,"oldOrganization":17},"PRINCIPAL_INVESTIGATOR","Yelda Erdem Hepşenoğlu","Director, Clinical Research","100659800","postoperative-pain-and-success-of-single-visit-root-canal-treatment-using-different-root-canal-sealers-in-asymptomatic-teeth-100659800",false,"NCT07868315","Postoperative Pain and Success of Single-Visit Root Canal Treatment Using Different Root Canal Sealers in Asymptomatic Teeth","Inclusion Criteria:\n\n* Patients aged 18-65 years.\n* Patients classified as ASA Physical Status I or II according to the American Society of Anesthesiologists (ASA) classification:\n* Teeth that have not previously undergone root canal retreatment or surgical intervention.\n* Patients who are able to read and sign the informed consent form.\n* Patients who are physically and mentally able to tolerate the planned dental treatment.\n* Teeth treated in a single treatment session.\n\nExclusion Criteria:\n\n* Pregnant or lactating women.\n* Patients with chronic periodontal disease and\u002For a periodontal probing depth \\>4 mm.\n* Symptomatic patients.\n* Patients who are unable to comply with the scheduled follow-up periods.\n* Patients who have used analgesics within 1 week or antibiotics within 1 month prior to treatment.\n* Teeth with root resorption.\n* Teeth with a vertical root fracture or a risk of vertical root fracture.\n* Teeth with incomplete root development.","ALL","18 Years","65 Years",{"count":107,"type":108},200,"ESTIMATED","INTERVENTIONAL",[111],"NA","This study evaluates the postoperative pain and long-term clinical and radiographic success of single-visit primary root canal treatment in asymptomatic teeth with periapical lesions.",[114,115],"Single-visit","Periapical Periodontitis",[117,118,119,120,121],"treatment outcome","periapical health","post operative pain","periapical index","Chronic apical periodontitis","2026-10-08",{"date":124,"type":125},"2026-10-09","ACTUAL",{"date":127,"type":125},"2025-04-22",{"date":129,"type":108},"2027-11-10",{"name":5,"class":6},1]