[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558710":3},{"organization":4,"outcomesModule":7,"designInfo":80,"detailedDescription":79,"studyPopulation":79,"armGroups":88,"interventions":106,"overallOfficials":79,"centralContacts":117,"locations":126,"responsibleParty":141,"collaborators":79,"id":143,"slug":144,"hasResults":145,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":79,"eligibilityCriteria":149,"healthyVolunteers":145,"sex":150,"minAge":151,"maxAge":152,"enrollmentInfo":153,"targetDuration":79,"studyType":156,"phases":157,"briefSummary":159,"conditions":160,"keywords":79,"overallStatus":128,"whyStopped":79,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":171},{"fullName":5,"class":6},"The Hong Kong Polytechnic University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":79},[9],{"measure":10,"description":11,"timeFrame":12},"Change from Baseline in Muscle Power at Week 12","Muscle power (watt) of knee extensors on both the paretic and nonparetic sides will be measured using the isokinetic dynamometer.\n\nChange=(Week 12 Level - Baseline Level)","Baseline and Week 12",[14,18,21,24,27,30,33,36,39,42,45,49,52,55,58,61,64,67,70,73,76],{"measure":15,"description":16,"timeFrame":17},"Change from Baseline in Muscle Power at Week 24","Muscle power (watt) of knee extensors on both the paretic and nonparetic sides will be measured using the isokinetic dynamometer. Change=(Week 24 Level - Baseline Level)","Baseline and Week 24",{"measure":19,"description":20,"timeFrame":12},"Change from Baseline in Muscle Strength (Nm) at Week 12","Muscle strength (Nm) of knee extensors on both the paretic and nonparetic sides will be measured using the isokinetic dynamometer.\n\nChange=(Week 12 Level - Baseline Level)",{"measure":22,"description":23,"timeFrame":17},"Change from Baseline in Muscle Strength (Nm) at Week 24","Muscle strength (Nm) of knee extensors on both the paretic and nonparetic sides will be measured using the isokinetic dynamometer.\n\nChange=(Week 24 Level - Baseline Level)",{"measure":25,"description":26,"timeFrame":12},"Change from Baseline in Muscle Strength (kg) at Week 12","Handgrip strength (kg) on both sides will be measured using a handheld dynamometer.\n\nChange=(Week 12 Level - Baseline Level)",{"measure":28,"description":29,"timeFrame":17},"Change from Baseline in Muscle Strength (kg) at Week 24","Handgrip strength (kg) on both sides will be measured using a handheld dynamometer.\n\nChange=(Week 24 Level - Baseline Level)",{"measure":31,"description":32,"timeFrame":12},"Change from Baseline in Body Composition (kg) at Week 12","Whole-body skeletal muscle mass (kg), bone mineral content (kg), fat mass (kg), and segmental lean mass (kg) will be measured using bioelectrical impedance analysis (BIA).\n\nChange=(Week 12 Level - Baseline Level)",{"measure":34,"description":35,"timeFrame":17},"Change from Baseline in Body Composition (kg) at Week 24","Whole-body skeletal muscle mass (kg), bone mineral content (kg), fat mass (kg), and segmental lean mass (kg) will be measured using bioelectrical impedance analysis (BIA).\n\nChange=(Week 24 Level - Baseline Level)",{"measure":37,"description":38,"timeFrame":12},"Change from Baseline in Body Composition (%) at Week 12","Body fat percentage (%) will be measured using bioelectrical impedance analysis (BIA).\n\nChange=(Week 12 Level - Baseline Level)",{"measure":40,"description":41,"timeFrame":17},"Change from Baseline in Body Composition (%) at Week 24","Body fat percentage (%) will be measured using bioelectrical impedance analysis (BIA).\n\nChange=(Week 24 Level - Baseline Level)",{"measure":43,"description":44,"timeFrame":12},"Change from Baseline in Biomarkers at Week 12","Volume-corrected serum concentration (mg\u002FdL) of myokines, bone markers, pro-inflammatory markers, biomarkers of oxidative stress will be measured using enzyme-linked immunosorbent assay (ELISA) kits.\n\nChange=(Week 12 Level - Baseline Level)",{"measure":46,"description":47,"timeFrame":48},"Change from Baseline in Biomarkers at Week 6","Volume-corrected serum concentration (mg\u002FdL) of myokines, bone markers, pro-inflammatory markers, biomarkers of oxidative stress will be measured using enzyme-linked immunosorbent assay (ELISA) kits.\n\nChange=(Week 6 Level - Baseline Level)","Baseline and Week 6",{"measure":50,"description":51,"timeFrame":12},"Change from Baseline in Motor Function at Week 12","Fugl-Meyer Motor Assessment (FMA) will be used to assess the degree of motor recovery of the hemiparetic upper (range: 0-66) and lower limbs (range: 0-34). Higher scores are indicative of better motor recovery. Short Physical Performance Battery (SPPB) will be used to assess the physical performance, including 5-times sit-to-stand, balance tests (side-by-side-stand, semi-tandem stand, and tandem stand), and gait speed.\n\nChange=(Week 12 Score- Baseline Score)",{"measure":53,"description":54,"timeFrame":17},"Change from Baseline in Motor Function at Week 24","Fugl-Meyer Motor Assessment (FMA) will be used to assess the degree of motor recovery of the hemiparetic upper (range: 0-66) and lower limbs (range: 0-34). Higher scores are indicative of better motor recovery. Short Physical Performance Battery (SPPB) will be used to assess the physical performance, including 5-times sit-to-stand, balance tests (side-by-side-stand, semi-tandem stand, and tandem stand), and gait speed.\n\nChange=(Week 24 Score- Baseline Score)",{"measure":56,"description":57,"timeFrame":12},"Change from Baseline in Motor Function (meters) at Week 12","The 6-minute walk test (6MWT) will be used to measure walking endurance and capacity. The total distance walked in meters during the test will be recorded.\n\nChange=(Week 12 distance - Baseline distance)",{"measure":59,"description":60,"timeFrame":17},"Change from Baseline in Motor Function (meters) at Week 24","The 6-minute walk test (6MWT) will be used to measure walking endurance and capacity. The total distance walked in meters during the test will be recorded.\n\nChange=(Week 24 distance - Baseline distance)",{"measure":62,"description":63,"timeFrame":12},"Change from Baseline in Balance Function at Week 12","Balance performance will be assessed using the Mini Balance Evaluation Systems Test (range: 0-28). Higher scores are indicative of better balance performance. Fear of falling will be assessed using the Chinese version of the Activities-Specific Balance Confidence Scale (range: 0-100). Higher scores are indicative of higher balance confidence.\n\nChange=(Week 12 Score- Baseline Score)",{"measure":65,"description":66,"timeFrame":17},"Change from Baseline in Balance Function at Week 24","Balance performance will be assessed using the Mini Balance Evaluation Systems Test (range: 0-28). Higher scores are indicative of better balance performance. Fear of falling will be assessed using the Chinese version of the Activities-Specific Balance Confidence Scale (range: 0-100). Higher scores are indicative of higher balance confidence.\n\nChange=(Week 24 Score- Baseline Score)",{"measure":68,"description":69,"timeFrame":12},"Change from Baseline in Cardiopulmonary Response at Week 12","Peak oxygen uptake (VO2peak) will be measured using a graded exercise test (GXT). The GXT will be conducted following a well-validated protocol that on a whole-body recumbent stepper to assess cardiopulmonary function in stroke patients.\n\nChange=(Week 12 VO2peak - Baseline VO2peak)",{"measure":71,"description":72,"timeFrame":17},"Change from Baseline in Cardiopulmonary Response at Week 24","Peak oxygen uptake (VO2peak) will be measured using a graded exercise test (GXT). The GXT will be conducted following a well-validated protocol that on a whole-body recumbent stepper to assess cardiopulmonary function in stroke patients.\n\nChange=(Week 24 VO2peak - Baseline VO2peak)",{"measure":74,"description":75,"timeFrame":12},"Change from Baseline in Psychosocial Responses at Week 12","Post-stroke fatigue will be assessed using the Fatigue Severity Scale (range: 1-7). Higher scores are indicative of more severe fatigue.\n\nHealth-related quality of life will be assessed using 12-Item Short Form Health Survey (range: 0-100). Higher scores are indicative of better quality of life.\n\nExercise enjoyment will be assessed by the Physical Activity Enjoyment Scale and Behavioural Regulation Exercise Questionnaire-3 (range: 0-400). Higher scores indicate a higher exercise enjoyment level.\n\nMotivation for exercise will be assessed using the Behavioural Regulation Exercise Questionnaire-3 (range: 0-96). Higher scores indicate more motivation to exercise. A semi-structured interview will be additionally conducted at the end of the intervention (week 12) to explore the experiences of HIIT in stroke patients.\n\nChange=(Week 12 Score - Baseline Score)",{"measure":77,"description":78,"timeFrame":17},"Change from Baseline in Psychosocial Responses at Week 24","Post-stroke fatigue will be assessed using the Fatigue Severity Scale (range: 1-7). Higher scores are indicative of more severe fatigue.\n\nHealth-related quality of life will be assessed using 12-Item Short Form Health Survey (range: 0-100). Higher scores are indicative of better quality of life.\n\nExercise enjoyment will be assessed by the Physical Activity Enjoyment Scale and Behavioural Regulation Exercise Questionnaire-3 (range: 0-400). Higher scores indicate a higher exercise enjoyment level.\n\nMotivation for exercise will be assessed using the Behavioural Regulation Exercise Questionnaire-3 (range: 0-96). Higher scores indicate more motivation to exercise. A semi-structured interview will be additionally conducted at the end of the intervention (week 12) to explore the experiences of HIIT in stroke patients.\n\nChange=(Week 24 Score - Baseline Score)",null,{"allocation":81,"interventionModel":82,"interventionModelDescription":79,"primaryPurpose":83,"observationalModel":79,"timePerspective":79,"maskingInfo":84},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":85,"maskingDescription":79,"whoMasked":86},"SINGLE",[87],"OUTCOMES_ASSESSOR",[89,95,101],{"label":90,"type":91,"description":92,"interventionNames":93},"High-intensity interval training","EXPERIMENTAL","The HIIT session will consist of a 3-minute warm-up, a 20-minute main exercise, and a 2-minute cool-down. The main exercise for HIIT will include ten high-intensity intervals, interspersed with ten low-intensity intervals.",[94],"Behavioral: High-intensity Interval Training",{"label":96,"type":97,"description":98,"interventionNames":99},"Moderate-intensity continuous training","ACTIVE_COMPARATOR","The MICT session will consist of a 3-minute warm-up, a main exercise that approximately matches the total workload of the HIIT session (lasting about 30 minutes), and a 2-minute cool-down. The intensity during the main exercise for MICT will remain below the vigorous level by progressively adjusting the workload throughout the intervention period.",[100],"Behavioral: Moderate-Intensity Continuous Training",{"label":102,"type":97,"description":103,"interventionNames":104},"Stretching","The stretching group will receive 25 minutes of whole-body stretching.",[105],"Behavioral: Stretching",[107,112,115],{"type":108,"name":109,"description":110,"armGroupLabels":111,"otherNames":79},"BEHAVIORAL","High-intensity Interval Training","There will be three sessions per week for 12 consecutive weeks, totaling 36 training sessions.",[90],{"type":108,"name":113,"description":110,"armGroupLabels":114,"otherNames":79},"Moderate-Intensity Continuous Training",[96],{"type":108,"name":102,"description":110,"armGroupLabels":116,"otherNames":79},[102],[118,123],{"name":119,"role":120,"phone":121,"phoneExt":79,"email":122},"Chen Xu, PhD student","CONTACT","00000000","rschen.xu@connect.polyu.hk",{"name":124,"role":120,"phone":121,"phoneExt":79,"email":125},"Meizhen Huang, PhD","mei-zhen.huang@polyu.edu.hk",[127],{"facility":5,"status":128,"city":129,"state":79,"zip":79,"country":130,"countryCode":131,"cosmosGeoPoint":132,"geoPoint":137,"contacts":138},"RECRUITING","Kowloon","Hong Kong","HK",{"type":133,"coordinates":134},"Point",[135,136],114.18333,22.31667,{"lat":136,"lon":135},[139,140],{"name":119,"role":120,"phone":79,"phoneExt":79,"email":122},{"name":124,"role":120,"phone":79,"phoneExt":79,"email":125},{"type":142,"investigatorFullName":79,"investigatorTitle":79,"investigatorAffiliation":79,"oldNameTitle":79,"oldOrganization":79},"SPONSOR","100558710","powering-up-stroke-rehabilitation-through-hiit-100558710",false,"NCT06554665","Powering Up Stroke Rehabilitation Through HIIT","Powering Up Stroke Rehabilitation Through High-Intensity Interval Training","Inclusion criteria:\n\n* Men and postmenopausal women aged 50-80 years\n* 1-5 years following the first-ever stroke confirmed by magnetic resonance imaging or computed tomography\n* Able to walk 10 meters independently with or without a walking aid\n* Class I or II according to the New York Heart Association Functional Classification (no limitation or slight limitation of physical activity due to symptoms during ordinary physical activity)\n\nExclusion criteria:\n\n* Presence of other neurological comorbidities, significant liver or renal diseases, thyroid or parathyroid diseases, rheumatoid arthritis, or a fracture within the past 6 months\n* Undergoing osteoporosis treatments within the past 3 years, use of oral corticosteroids for more than 3 months within the past year, or botulinum toxin injections in the paretic lower limb within the past 6 months\n* Participation in ongoing stroke rehabilitation services or structured exercise programme\n* Cognitive or communication issues that could limit the ability to follow instructions\n* Contraindications to HIIT, graded exercise testing, or failure to pass medical clearance from a specialist","ALL","50 Years","80 Years",{"count":154,"type":155},66,"ESTIMATED","INTERVENTIONAL",[158],"NA","Objectives: To investigate the effects of high-intensity interval training (HIIT) on musculoskeletal fitness in chronic stroke survivors.\n\nHypothesis to be tested: HIIT, performed on a recumbent stepper, will significantly enhance muscle power in chronic stroke survivors when compared with moderate-intensity continuous training (MICT) Design and subjects: Assessor-blinded, stratified, randomised, placebo-controlled clinical trial involving eligible 66 chronic stroke survivors.\n\nInterventions: Participants will be randomly allocated to one of three groups: the HIIT group, the MICT group, or a stretching group (active control). Each group will attend sessions three times per week for 12 consecutive weeks, totaling 36 training sessions.\n\nMain outcome measures: Assessments will be conducted at baseline, at mid-term of the intervention (week 6), at the end of the intervention (week 12), and at a 12-week follow-up (week 24). The primary outcome measure will be muscle power. Secondary outcome measures will include muscle strength, body composition, biomarkers, motor function, balance function, cardiorespiratory response, and psychosocial response.",[161],"Stroke","2026-09-17",{"date":164,"type":165},"2026-09-21","ACTUAL",{"date":167,"type":165},"2024-08-20",{"date":169,"type":155},"2027-08-05",{"name":5,"class":6},1]