[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100659727":3},{"organization":4,"outcomesModule":7,"designInfo":29,"detailedDescription":38,"studyPopulation":28,"armGroups":39,"interventions":51,"overallOfficials":57,"centralContacts":62,"locations":28,"responsibleParty":68,"collaborators":28,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":28,"eligibilityCriteria":78,"healthyVolunteers":74,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":28,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":97,"whyStopped":28,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":28},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":28},[9],{"measure":10,"description":11,"timeFrame":12},"Incidence of post-induction hypotension","Number of patients with mean arterial pressure drop greater than 20% from baseline or mean arterial pressure less than 65 mmHg within the first 30 minutes after induction of general anesthesia.","Periprocedurally",[14,17,21,24],{"measure":15,"description":16,"timeFrame":12},"Mean arterial pressure","Mean arterial pressure in mmHg.",{"measure":18,"description":19,"timeFrame":20},"Total dose of rescue vasopressors","Mean total dose of rescue vasopressors administered intraoperatively in micrograms.","Immediately after the intervention\u002Fprocedure\u002Fsurgery",{"measure":22,"description":23,"timeFrame":20},"Total volume of intravenous fluids","Mean total volume of intravenous fluids administered intraoperatively in milliliters.",{"measure":25,"description":26,"timeFrame":27},"Length of ICU stay","Mean length of intensive care unit stay in days.","At 28 days",null,{"allocation":30,"interventionModel":31,"interventionModelDescription":28,"primaryPurpose":32,"observationalModel":28,"timePerspective":28,"maskingInfo":33},"RANDOMIZED","PARALLEL","PREVENTION",{"masking":34,"maskingDescription":28,"whoMasked":35},"DOUBLE",[36,37],"PARTICIPANT","OUTCOMES_ASSESSOR","Induction of general anesthesia in septic patients can cause severe hypotension due to vasodilation and reduced preload. Pre-emptive norepinephrine infusion may prevent post-induction hemodynamic collapse.\n\nThis prospective double-blind randomized trial will compare continuous prophylactic norepinephrine infusion started 30 minutes before induction versus standard care with rescue vasopressors only in adult septic patients undergoing surgery.",[40,46],{"label":41,"type":42,"description":43,"interventionNames":44},"Early Norepinephrine","EXPERIMENTAL","Continuous intravenous norepinephrine infusion at 0.07 mcg\u002Fkg\u002Fmin initiated 30 minutes before induction of general anesthesia and maintained intraoperatively.",[45],"Drug: Norepinephrine",{"label":47,"type":48,"description":49,"interventionNames":50},"Control","ACTIVE_COMPARATOR","No prophylactic norepinephrine before induction. Vasopressors administered only as rescue medication for hypotension.",[45],[52],{"type":53,"name":54,"description":55,"armGroupLabels":56,"otherNames":28},"DRUG","Norepinephrine","Continuous intravenous infusion of norepinephrine.",[47,41],[58],{"name":59,"affiliation":60,"role":61},"Hamdy A Yousef, prof","Anaesthesia , ICU and pain management Department, Assiut University Hospitals","STUDY_CHAIR",[63],{"name":64,"role":65,"phone":66,"phoneExt":28,"email":67},"Rofaida M ashry, Resident","CONTACT","01003823614","rofaida.ashry@gmail.com",{"type":69,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"PRINCIPAL_INVESTIGATOR","Rofaida mamdouh ashry","Resident Physician, Anaesthesia , ICU and pain management department","100659727","pre-induction-norepinephrine-in-septic-patients-undergoing-surgery-100659727",false,"NCT07869693","Pre-induction Norepinephrine in Septic Patients Undergoing Surgery","Effect of Pre-induction Norepinephrine Initiation on Peri-operative Hemodynamic Stability in Septic Patients With SOFA Score ≥2 Undergoing Surgery Under General Anesthesia","Inclusion Criteria:\n\n* \\- Age 18 to 65 years\n* Diagnosed with severe sepsis with SOFA score ≥2\n* Scheduled for surgery under general anesthesia\n* ASA physical status III or IV\n* Written informed consent\n\nExclusion Criteria:\n\n* Severe pre-existing cardiovascular compromise\n* Known allergy or hypersensitivity to norepinephrine\n* Pregnancy or lactation\n* Refusal to participate","ALL","18 Years","65 Years",{"count":83,"type":84},90,"ESTIMATED","INTERVENTIONAL",[87],"NA","This randomized controlled trial aims to evaluate the effect of early pre-induction norepinephrine infusion on perioperative hemodynamic stability in septic patients with SOFA score ≥2 undergoing surgery under general anesthesia.",[90,91],"Sepsis","Hypotension",[54,93,94,95,96,90],"Assiut","General anesthesia","Hemodynamic stability","SOFA score","NOT_YET_RECRUITING","2026-10-06",{"date":100,"type":101},"2026-10-09","ACTUAL",{"date":103,"type":84},"2026-10-10",{"date":105,"type":84},"2028-02-01",{"name":5,"class":6}]