[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100655421":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":13,"studyPopulation":13,"armGroups":24,"interventions":37,"overallOfficials":13,"centralContacts":46,"locations":52,"responsibleParty":74,"collaborators":13,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":13,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":13,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":55,"whyStopped":13,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Xinhua Hospital, Shanghai Jiao Tong University School of Medicine","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Proportion of participants with iron deficiency anemia during late pregnancy","Iron deficiency anemia is defined as a hemoglobin concentration of less than 110 g\u002FL and a serum ferritin concentration of less than 20 μg\u002FL, measured in the same blood sample. Participants meeting both criteria at least once during any scheduled assessment from 28 weeks' gestation through delivery will be classified as having the primary outcome.","From 28 weeks' gestation to delivery",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":17,"primaryPurpose":18,"observationalModel":13,"timePerspective":13,"maskingInfo":19},"RANDOMIZED","PARALLEL","Parallel, two-arm cluster randomized trial. Townships are randomized in a 1:1 ratio to preconception or early-pregnancy anemia screening and treatment strategies.","PREVENTION",{"masking":20,"maskingDescription":21,"whoMasked":22},"SINGLE","The trial is open label for participants, care providers, and investigators. Outcome assessors will be blinded to cluster allocation.",[23],"OUTCOMES_ASSESSOR",[25,31],{"label":26,"type":27,"description":28,"interventionNames":29},"Preconception Group","EXPERIMENTAL","Townships assigned to this group implement anemia screening and indicated iron treatment before conception.",[30],"Other: Preconception Anemia Screening and Treatment Strategy",{"label":32,"type":33,"description":34,"interventionNames":35},"Early-Pregnancy Group","ACTIVE_COMPARATOR","Townships assigned to this group implement the same anemia screening and indicated iron treatment during early pregnancy.",[36],"Other: Early-Pregnancy Anemia Screening and Treatment Strategy",[38,42],{"type":6,"name":39,"description":40,"armGroupLabels":41,"otherNames":13},"Preconception Anemia Screening and Treatment Strategy","Women planning pregnancy within 6 months undergo hemoglobin, hemoglobin electrophoresis, and serum ferritin assessments before conception. Those with hemoglobin levels below 120 g\u002FL and\u002For serum ferritin levels below 30 μg\u002FL receive oral ferrous succinate (0.2 g twice daily) plus vitamin C, with scheduled hematologic monitoring.",[26],{"type":6,"name":43,"description":44,"armGroupLabels":45,"otherNames":13},"Early-Pregnancy Anemia Screening and Treatment Strategy","Women with a singleton pregnancy at 12 weeks' gestation who have hemoglobin levels below 110 g\u002FL and\u002For serum ferritin levels below 30 μg\u002FL will receive oral ferrous succinate (0.2 g twice daily) plus vitamin C, with scheduled hematologic monitoring",[32],[47],{"name":48,"role":49,"phone":50,"phoneExt":13,"email":51},"Peipei Hu","CONTACT","+86-21-25076143","hupphpp@163.com",[53],{"facility":54,"status":55,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"Yanjin County Maternal and Child Health Hospital","RECRUITING","Zhaotong","Yunnan","657500","China","CN",{"type":62,"coordinates":63},"Point",[64,65],103.71667,27.31667,{"lat":65,"lon":64},[68,72],{"name":69,"role":49,"phone":70,"phoneExt":13,"email":71},"Guimin Huang Huang","13608704462","394128854@qq.com",{"name":73,"role":49,"phone":13,"phoneExt":13,"email":13},"Peipei Hu Hu",{"type":75,"investigatorFullName":13,"investigatorTitle":13,"investigatorAffiliation":13,"oldNameTitle":13,"oldOrganization":13},"SPONSOR","100655421","preconception-vs-first-trimester-screening-and-treatment-for-iron-deficiency-anemia-a-cluster-randomized-trial-100655421",false,"NCT07811765","Preconception vs First-Trimester Screening and Treatment for Iron Deficiency Anemia","Effect of Anemia Intervention Timing (Preconception vs. First Trimester) on the Control of Iron Deficiency Anemia in the Third Trimester: A Cluster Randomized Controlled Trial","Inclusion Criteria:\n\n* Women aged 18-45 years\n* Residence in a participating township\n* Intention to attempt natural conception within 6 months after enrollment\n* Ability to complete the required study procedures\n* Ability and willingness to provide written informed consent\n\nExclusion Criteria:\n\n* 1.Non-iron deficiency anemia or other hematologic disorders: thalassemia, sickle cell anemia, anemia of chronic disease, and other hematologic conditions will be excluded based on complete blood count findings (including hemoglobin concentration) in combination with questionnaire assessment. Renal insufficiency (eGFR \\\u003C45 mL\u002Fmin\u002F1.73 m²)\n\n  2: hepatic insufficiency (ALT or AST \\>3 times the upper limit of normal)\n\n  3: uncontrolled heart disease (New York Heart Association \\[NYHA\\] functional class III-IV) Acute or chronic infections, including HIV infection, active tuberculosis, and uncontrolled hepatitis B Multiple pregnancy\n\n  4: current pregnancy complicated by major fetal malformations or chromosomal abnormalities\n\n  5: history or current diagnosis of preeclampsia, placental abruption, or placenta previa History of hypersensitivity to intravenous iron therapy or iron overload disorders\n\n  6: receipt of blood transfusion or intravenous iron therapy within 1 month before enrollment Psychiatric disorders or cognitive impairment that would interfere with study participation or compliance with study procedures",true,"FEMALE","18 Years","45 Years",{"count":88,"type":89},960,"ESTIMATED","INTERVENTIONAL",[92],"NA","This cluster randomized trial compares preconception with early-pregnancy anemia screening and iron supplementation, assessing late pregnancy iron deficiency anemia and maternal and infant outcomes.",[95],"Iron Deficiency Anemia",[97,98,99,95,100],"Anemia Intervention Timing","Preconception","First Trimester","Randomized Controlled Trial","2026-09-14",{"date":103,"type":104},"2026-09-17","ACTUAL",{"date":106,"type":104},"2026-07-10",{"date":108,"type":89},"2029-07",{"name":5,"class":6},1]