[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100657589":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":17,"studyPopulation":18,"armGroups":13,"interventions":13,"overallOfficials":19,"centralContacts":28,"locations":37,"responsibleParty":52,"collaborators":13,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":13,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":13,"studyType":69,"phases":13,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":76,"whyStopped":13,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Ain Shams Maternity Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Myometrial thickness as a predictor of latency interval in patients with preterm prelabor rupture of membranes","Correlation between myometrial thickness at each uterine measurement site and latency interval in patients with preterm prelabor rupture of membranes","the period from membrane rupture to 24 hours after membrane rupture",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":16,"maskingInfo":13},"COHORT","PROSPECTIVE","PPROM is a major obstetric complication, occurring in approximately 3% of pregnancies and accounting for 30-40% of preterm births worldwide. It is defined as rupture of the fetal membranes before the onset of labor and prior to 37 weeks of gestation, creating a clinical dilemma that balances the risks of prematurity against the dangers of prolonged membrane rupture. The condition carries significant perinatal morbidity and mortality, including respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis, and neonatal sepsis, alongside maternal complications such as chorioamnionitis and postpartum hemorrhage.\n\nThe latency period, defined as the interval between membrane rupture and delivery, is a critical determinant of neonatal outcomes. A longer latency permits completion of antenatal corticosteroid therapy for fetal lung maturation and antibiotic prophylaxis, thereby improving neonatal prognosis. Conversely, prolonged latency increases the risk of ascending infection, chorioamnionitis, and placental abruption, necessitating careful and individualized management, Current evidence indicates that approximately 50% of affected women deliver within 48 hours, and 70-90% within one week of membrane rupture, although latency may occasionally extend for several weeks in cases of very early PPROM according to recommendations of the American College of Obstetricians and Gynecologists.\n\nStandard management between 24 and 34 weeks includes hospitalization, antibiotic prophylaxis, antenatal corticosteroids, and magnesium sulfate for neuroprotection before 32 weeks, alongside close maternal-fetal surveillance. Despite these well-established interventions, accurate prediction of latency duration remains a significant clinical challenge. Traditional predictors such as gestational age at rupture, amniotic fluid volume, cervical length, fetal fibronectin, and inflammatory markers have demonstrated variable sensitivity and specificity across different populations, limiting their widespread clinical utility.\n\nUltrasonographic assessment has become integral to PPROM management, and recent attention has focused on myometrial thickness (MT) as a potential non-invasive predictor of labor onset and delivery timing. The myometrium undergoes dynamic structural and functional changes throughout pregnancy, with thickness variations reflecting uterine contractility patterns, inflammatory responses, and the risk of imminent delivery. Studies in women with threatened preterm labor have shown that increased MT particularly at the lower uterine segment correlates with heightened uterine activity and a shorter interval to delivery . Ultrasonography provides a non-invasive method for assessing uterine morphology and myometrial activity, with increasing interest in its potential role in predicting the onset of preterm labor.\n\nDespite encouraging preliminary findings, evidence regarding the predictive value of MT in women with PPROM remains limited, and further prospective studies are required before its routine clinical application. Furthermore, in middle-income countries, such as Egypt, where preterm birth remains a major contributor to neonatal morbidity and mortality, the development of accessible, affordable, and non-invasive predictive tools for women with PPROM is of particular clinical importance. The wide availability of ultrasound equipment makes MT measurement a feasible and cost-effective addition to routine PPROM assessment, without requiring specialized biochemical assays or advanced technology.\n\nThis study therefore aims to prospectively evaluate the association between MT at multiple uterine sites and the latency interval in women with PPROM. Cut-off values predictive of imminent delivery can be incorporated into clinical management algorithms for this challenging obstetric condition.","Pregnant women with preterm prelabor rupture of membranes presenting to Ain Shams University Maternity Hospital.",[20,24],{"name":21,"affiliation":22,"role":23},"Mohamed Serag","Faculty of Medicine - Ain Shams university","STUDY_CHAIR",{"name":25,"affiliation":26,"role":27},"Walid Tantawy, M.D.,","Faculty of Medicine - Modern University for Technology and Information","STUDY_DIRECTOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":13,"email":33},"Ahmed ElMaraghy, M.D,","CONTACT","+201010370980","ahmedelmaraghy@med.asu.edu.eg",{"name":35,"role":31,"phone":13,"phoneExt":13,"email":36},"Hamdy Alqenawy, M.D.,","hamdybakry@med.asu.edu.eg",[38],{"facility":39,"status":13,"city":40,"state":13,"zip":13,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Ainshams University maternity hospital","Cairo","Egypt","EG",{"type":44,"coordinates":45},"Point",[46,47],31.24967,30.06263,{"lat":47,"lon":46},[50],{"name":51,"role":31,"phone":13,"phoneExt":13,"email":33},"Ahmed M ElMaraghy",{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"PRINCIPAL_INVESTIGATOR","Ahmed Mohammed Elmaraghy","Associate Professor","100657589","prediction-of-latency-interval-in-patients-with-preterm-prelabor-rupture-of-membranes-100657589",false,"NCT07841587","Prediction of Latency Interval in Patients With Preterm Prelabor Rupture of Membranes","Myometrial Thickness as a Predictor of Latency Interval in Preterm Prelabor Rupture of Membranes: A Prospective Cohort Study","Inclusion Criteria:\n\n* Gestational age 28-34 weeks at membrane rupture\n* Presenting to the hospital within 24 hours of PPROM\n\nExclusion Criteria:\n\n* Women with contraindications to conservative management. Clinical chorioamnionitis at presentation. Patients presenting in labor Intrauterine fetal death\n\nMedical\u002FObstetric indications for immediate delivery at presentation:\n\nSevere preeclampsia. Bleeding: placenta previa or placental abruption\n\n* Women with other risk factors for preterm birth. Fetal growth restriction with lost end-diastolic flow in umbilical artery Known uterine anomalies Multifetal gestation\n* Previous uterine surgery (e.g., myomectomy, classical cesarean section)\n* Morbidly obese women rendering sonographic assessment inaccurate","FEMALE","18 Years","40 Years",{"count":67,"type":68},50,"ESTIMATED","OBSERVATIONAL","Prediction of latency interval in Preterm prelabor rupture of membranes (PPROM) remains challenging in clinical practice, Myometrial thickness (MT) has emerged as a potential ultrasound marker for predicting the risk of preterm labor.\n\nThis study aims to prospectively evaluate the correlation between MT measurements at multiple uterine sites and latency interval in women with PPROM.",[72],"Preterm Prelabor Rupture of Membranes (PPROM)",[74,75],"Myometrial thickness - Latency interval","Preterm prelabor rupture of membranes","NOT_YET_RECRUITING","2026-10-02",{"date":79,"type":80},"2026-10-06","ACTUAL",{"date":82,"type":68},"2026-10-01",{"date":84,"type":68},"2027-03",{"name":5,"class":6},1]