[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100656177":3},{"organization":4,"outcomesModule":7,"designInfo":33,"detailedDescription":36,"studyPopulation":37,"armGroups":38,"interventions":32,"overallOfficials":42,"centralContacts":47,"locations":32,"responsibleParty":53,"collaborators":32,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":32,"eligibilityCriteria":62,"healthyVolunteers":59,"sex":63,"minAge":32,"maxAge":64,"enrollmentInfo":65,"targetDuration":68,"studyType":69,"phases":32,"briefSummary":70,"conditions":71,"keywords":74,"overallStatus":82,"whyStopped":32,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":32},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":32},[9],{"measure":10,"description":11,"timeFrame":12},"In-hospital mortality","Proportion of neonates with persistent pulmonary hypertension who die before hospital discharge.","Up to 30 days",[14,17,20,23,26,29],{"measure":15,"description":16,"timeFrame":12},"Duration of mechanical ventilation","Total number of days of invasive mechanical ventilation.",{"measure":18,"description":19,"timeFrame":12},"Duration of oxygen therapy","Total number of days requiring supplemental oxygen.",{"measure":21,"description":22,"timeFrame":12},"Use of sildenafil","Proportion of neonates who receive sildenafil therapy.",{"measure":24,"description":25,"timeFrame":12},"Use of inotropes","Proportion of neonates who receive inotropic support",{"measure":27,"description":28,"timeFrame":12},"Duration of NICU stay","Length of stay in the neonatal intensive care unit in days.",{"measure":30,"description":31,"timeFrame":12},"Time to echocardiographic resolution","Number of days from diagnosis until echocardiographic resolution of pulmonary hypertension.",null,{"allocation":32,"interventionModel":32,"interventionModelDescription":32,"primaryPurpose":32,"observationalModel":34,"timePerspective":35,"maskingInfo":32},"COHORT","PROSPECTIVE","Persistent pulmonary hypertension of the newborn (PPHN) is a serious condition characterized by failure of the normal postnatal decline in pulmonary vascular resistance, leading to severe hypoxemia. Outcomes vary widely, ranging from complete recovery to death.\n\nThis observational study will include term and preterm neonates admitted to the NICU with clinical and echocardiographic evidence of pulmonary hypertension. Clinical, laboratory, and echocardiographic parameters will be recorded to identify predictors of mortality and other adverse outcomes.","Term and preterm neonates admitted to the Neonatal Intensive Care Unit of Assiut University Children Hospital with clinical and echocardiographic evidence of persistent pulmonary hypertension.",[39],{"label":40,"type":32,"description":41,"interventionNames":32},"Single cohort: Neonates with PPHN","Term and preterm neonates with clinical and echocardiographic evidence of persistent pulmonary hypertension who will be followed for clinical, laboratory, and echocardiographic predictors of outcome.",[43],{"name":44,"affiliation":45,"role":46},"Nagwa A Mohammed, prof","pediatrics Department, Assiut University Hospitals","STUDY_CHAIR",[48],{"name":49,"role":50,"phone":51,"phoneExt":32,"email":52},"Aya s Mohamed, Resident","CONTACT","+20 10 20640170","ayat.18313253@med.aun.edu.eg",{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"PRINCIPAL_INVESTIGATOR","Aya Saleh Mohammed","Resident Physician","100656177","predictors-of-outcomes-in-pulmonary-hypertension-of-the-newborn-100656177",false,"NCT07822750","Predictors of Outcomes in Pulmonary Hypertension of the Newborn","Inclusion Criteria:\n\n* \\- Neonates (term and preterm) admitted to the NICU\n* Clinical and echocardiographic evidence of pulmonary hypertension\n* Written informed consent from parents or legal guardians\n\nExclusion Criteria:\n\n* \\- Major structural cyanotic congenital heart disease\n* Lethal congenital anomalies or chromosomal abnormalities incompatible with survival","ALL","28 Days",{"count":66,"type":67},60,"ESTIMATED","30 Days","OBSERVATIONAL","This prospective cohort study aims to identify the clinical, laboratory, and echocardiographic predictors of outcomes among neonates diagnosed with persistent pulmonary hypertension of the newborn at Assiut University Children Hospital.",[72,73],"Hypertension, Pulmonary","Infant, Newborn, Diseases",[75,76,77,78,79,80,81],"hypertension of the newborn","Neonatal outcomes","PPHN","Mortality","Persistent pulmonary","Echocardiography","Assiut","NOT_YET_RECRUITING","2026-09-11",{"date":85,"type":86},"2026-09-16","ACTUAL",{"date":88,"type":67},"2026-09-10",{"date":90,"type":67},"2028-02-01",{"name":5,"class":6}]