[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100656257":3},{"organization":4,"outcomesModule":7,"designInfo":33,"detailedDescription":36,"studyPopulation":37,"armGroups":38,"interventions":32,"overallOfficials":45,"centralContacts":50,"locations":32,"responsibleParty":56,"collaborators":32,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":32,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":32,"maxAge":68,"enrollmentInfo":69,"targetDuration":72,"studyType":73,"phases":32,"briefSummary":74,"conditions":75,"keywords":79,"overallStatus":87,"whyStopped":32,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":93,"leadSponsor":95,"locationsCount":32},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":32},[9],{"measure":10,"description":11,"timeFrame":12},"Occurrence of prolonged mechanical ventilation","Proportion of preterm infants who require invasive mechanical ventilation for more than 7 days or frequent reintubation.","Up to 30 days",[14,17,20,23,26,29],{"measure":15,"description":16,"timeFrame":12},"Duration of invasive mechanical ventilation","Total number of days of invasive mechanical ventilation.",{"measure":18,"description":19,"timeFrame":12},"Successful extubation rate","Proportion of infants who are successfully extubated without re-intubation within 48-72 hours.",{"measure":21,"description":22,"timeFrame":12},"Incidence of bronchopulmonary dysplasia","Proportion of infants diagnosed with bronchopulmonary dysplasia.",{"measure":24,"description":25,"timeFrame":12},"Incidence of neonatal sepsis","Proportion of infants diagnosed with neonatal sepsis.",{"measure":27,"description":28,"timeFrame":12},"Duration of NICU stay","Length of stay in the neonatal intensive care unit in days.",{"measure":30,"description":31,"timeFrame":12},"In-hospital mortality","Proportion of infants who die before hospital discharge.",null,{"allocation":32,"interventionModel":32,"interventionModelDescription":32,"primaryPurpose":32,"observationalModel":34,"timePerspective":35,"maskingInfo":32},"COHORT","PROSPECTIVE","Prolonged mechanical ventilation in preterm infants is associated with increased morbidity including bronchopulmonary dysplasia and neurodevelopmental impairment. This prospective observational study will include preterm infants (born before 37 completed weeks) who require invasive mechanical ventilation.\n\nInfants will be classified into two groups according to the duration of invasive mechanical ventilation: prolonged (\\>7 days or frequent reintubation) and non-prolonged (≤7 days). clinical, perinatal, and laboratory predictors of prolonged mechanical ventilation will be evaluated.","Preterm infants admitted to the Neonatal Intensive Care Unit of Assiut University Children Hospital who require invasive mechanical ventilation.",[39,42],{"label":40,"type":32,"description":41,"interventionNames":32},"Prolonged Mechanical Ventilation","Preterm infants who require invasive mechanical ventilation for more than 7 days or frequent reintubation",{"label":43,"type":32,"description":44,"interventionNames":32},"Non-Prolonged Mechanical Ventilation","Preterm infants who require invasive mechanical ventilation for ≤7 days.",[46],{"name":47,"affiliation":48,"role":49},"Jaafar I Mohammed, prof","pediatrics Department, Assiut University Hospitals","STUDY_CHAIR",[51],{"name":52,"role":53,"phone":54,"phoneExt":32,"email":55},"Demiana Y Zakaria, Resident","CONTACT","0 1280798683","Demiana.16266368@med.aun.edu.eg",{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"PRINCIPAL_INVESTIGATOR","Demiana Youssef Zakaria Ghaly","Resident Physician","100656257","predictors-of-prolonged-mechanical-ventilation-in-preterm-infants-100656257",false,"NCT07821632","Predictors of Prolonged Mechanical Ventilation in Preterm Infants","Predictors of Prolonged Mechanical Ventilation in Preterm Infants Admitted to Neonatal Intensive Care Unit of Assiut University Children Hospital","Inclusion Criteria:\n\n* \\- Preterm infants born before 37 completed weeks of gestation\n* Admission to the NICU within the neonatal period\n* Requirement for invasive mechanical ventilation\n* Written informed consent from parents or legal guardians\n\nExclusion Criteria:\n\n* \\- Infants born after 37 weeks of gestation\n* Major congenital anomalies\n* Chromosomal abnormalities\n* Congenital neuromuscular disorders\n* Cyanotic congenital heart disease","ALL","36 Weeks",{"count":70,"type":71},100,"ESTIMATED","30 Days","OBSERVATIONAL","This prospective cohort study aims to identify the independent predictors of prolonged mechanical ventilation in preterm infants admitted to the Neonatal Intensive Care Unit of Assiut University Children Hospital.",[76,77,78],"Premature Birth","Respiration Failure","Bronchopulmonary Dysplasia",[80,81,82,83,84,85,86],"Prolonged mechanical","ventilation","Preterm infants","NICU","Predictors","Extubation","Assiut","NOT_YET_RECRUITING","2026-09-10",{"date":90,"type":91},"2026-09-16","ACTUAL",{"date":88,"type":71},{"date":94,"type":71},"2028-04-10",{"name":5,"class":6}]