[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649020":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":15,"collaborators":10,"id":19,"slug":20,"hasResults":21,"nctId":22,"briefTitle":23,"officialTitle":24,"acronym":10,"eligibilityCriteria":25,"healthyVolunteers":21,"sex":26,"minAge":27,"maxAge":10,"enrollmentInfo":28,"targetDuration":10,"studyType":31,"phases":10,"briefSummary":32,"conditions":33,"keywords":38,"overallStatus":44,"whyStopped":10,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":10},{"fullName":5,"class":6},"Assiut University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"ILD with Pulmonary Embolism (Cases)",null,"This group consists of adult patients (aged 18 years and older) with a confirmed diagnosis of Interstitial Lung Disease (ILD) who present with an acute unexplained worsening of respiratory symptoms (such as dyspnea, hypoxemia, chest pain, or syncope). These patients undergo Computed Tomography Pulmonary Angiography (CTPA) as part of routine clinical management and are confirmed to have acute pulmonary embolism.",{"label":13,"type":10,"description":14,"interventionNames":10},"ILD without Pulmonary Embolism (Controls)","This group consists of adult patients (aged 18 years and older) with a confirmed diagnosis of Interstitial Lung Disease (ILD) who present with an acute unexplained worsening of respiratory symptoms (such as dyspnea, hypoxemia, chest pain, or syncope). These patients undergo Computed Tomography Pulmonary Angiography (CTPA) as part of routine clinical management but have negative findings, confirming the absence of acute pulmonary embolism.",{"type":16,"investigatorFullName":17,"investigatorTitle":18,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Ziad Abd Elhady Sayed Abd Elaal","Resident at Chest Diseases Department","100649020","predictors-of-pulmonary-embolism-in-interstitial-lung-disease-with-worsening-symptoms-100649020",false,"NCT07728448","Predictors of Pulmonary Embolism in Interstitial Lung Disease With Worsening Symptoms","Predictors of Pulmonary Embolism in Patients With Interstitial Lung Diseases Presenting With Worsening Respiratory Symptoms","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Confirmed diagnosis of ILD based on multidisciplinary discussion and HRCT findings, with or without histopathological confirmation\n* Acute unexplained worsening of dyspnea, hypoxemia, chest pain, syncope, or clinical suspicion of PE\n* Undergoing CTPA as part of routine clinical management\n* Provision of informed consent\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Pregnancy\n* Previously diagnosed acute pulmonary embolism receiving anticoagulant therapy\n* Active malignancy\n* Known inherited or acquired thrombophilia\n* Acute myocardial infarction or ischemic stroke within the previous month\n* Major surgery or trauma within four weeks\n* Severe renal impairment contraindicating contrast-enhanced CTPA","ALL","18 Years",{"count":29,"type":30},70,"ESTIMATED","OBSERVATIONAL","People with interstitial lung disease (ILD) can sometimes experience a sudden and severe worsening of their breathing. While this can be caused by a flare-up of the lung disease itself, it can also be caused by a blood clot in the lungs, known as a pulmonary embolism (PE). It is often difficult for doctors to tell the difference between these two emergencies because their symptoms, such as shortness of breath and low oxygen levels, are very similar. Traditional scoring systems used to predict blood clots are often less accurate for patients who already have chronic lung diseases like ILD.\n\nThe main goal of this observational study is to find better, more reliable ways to predict which ILD patients with worsening breathing symptoms actually have a pulmonary embolism.\n\nResearchers will observe 70 adult patients with ILD who come to the hospital with a sudden worsening of their symptoms (such as shortness of breath, chest pain, or low oxygen) and who require a specific type of CT scan (Computed Tomography Pulmonary Angiography, or CTPA) as part of their standard medical care to check for blood clots.\n\nThe study will compare the patients whose CT scan confirms a blood clot to those whose scan does not show a clot. By comparing these two groups, the research team will evaluate various clinical signs, routine blood tests, novel inflammatory markers, and heart\u002Flung imaging details.\n\nIdentifying strong predictors of pulmonary embolism in this specific group of patients could help doctors diagnose lung blood clots faster and more accurately, leading to better clinical decision-making and improved patient outcomes",[34,35,36,37],"Pulmonary Embolism","Interstitial Lung Disease","Idiopathic Pulmonary Fibrosis","Connective Tissue Disease-associated Interstitial Lung Disease",[39,40,41,42,43],"Predictors","Inflammatory Biomarkers","Worsening Respiratory Symptoms","Computed Tomography Pulmonary Angiography (CTPA)","Acute Exacerbation","NOT_YET_RECRUITING","2026-07-22",{"date":47,"type":48},"2026-07-27","ACTUAL",{"date":50,"type":30},"2026-08",{"date":52,"type":30},"2027-09",{"name":5,"class":6}]