[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100604330":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":17,"studyPopulation":18,"armGroups":19,"interventions":25,"overallOfficials":30,"centralContacts":35,"locations":41,"responsibleParty":69,"collaborators":13,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":75,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":13,"studyType":87,"phases":13,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":58,"whyStopped":13,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"University of Algiers","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"1. Primary outcome: Prevalence of obstetrical events before the diagnosis of SLE. Secondary outcome: 1. Assess the severity of the disease at the time of LES diagnosis. 2. Compare the outcomes of pregnancies before and after the LES","* Evaluate the number of pregnancies for each woman before and after the diagnosis of lupus.\n* Assess obstetric events for each pregnancy (spontaneous abortion, prematurity, fetal death, pre-eclampsia, HELLP syndrome, or other pregnancy-related events).\n* Assess the presence of systemic signs during pregnancy or the postpartum period.\n* Collect data on the baby's status, including weight, height, and any morbid conditions (dermatological, cardiac, respiratory, etc.).\n* Note the timeframe between the last pregnancy or delivery and the SLE diagnosis.","The patient will be assessed from the beginning of each pregnancy and in the three month after childbirth",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":16,"maskingInfo":13},"COHORT","RETROSPECTIVE","The investigators aim to study obstetrical and systemic signs in participants' pregnancies prior to an SLE diagnosis. Information will be collected from medical records and by asking participants questions during medical visits. The diagnosis of SLE is made using the ACR 1997 criteria. It is also based on renal histological findings.\n\nThe study must answer three questions:\n\n1. Are systemic signs of SLE present before or during pregnancy?\n2. What were the fetal and maternal outcomes after or during each pregnancy? What is\u002Fwas the severity of SLE after diagnosis?","Eligible patients for the study are selected from all women diagnosed with lupus erythematosus in the Department of Internal Medicine at the Ain-Taya Teaching Hospital from 2000 to 2025. Patients are recruited from primary care, emergency units, or the gynecology and obstetrics department. These patients are being followed up in the Department of Internal Medicine at Ain-Taya Hospital.",[20],{"label":21,"type":13,"description":22,"interventionNames":23},"Femelle patients at procreation age with diagnosis of LES","Patients that have had pregnancies history before the diagnosis of LES",[24],"Other: Collect data on all pregnancies before and after diagnosis of SLE.",[26],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":13},"Collect data on all pregnancies before and after diagnosis of SLE.","For participants who are still alive, data are collected from interviews with patients using a prepared questionnaire that asks about all pregnancies and obstetrical events prior to the diagnosis of SLE.\n\nFor deceased patients, data are taken from the medical records of obstetrical events.\n\nData will be collected on anthropometric, biological, immunological, and histological features before and after the diagnosis of SLE, if available.\n\nThe activity and severity of the disease after diagnosis will be assessed using the recommended tools.",[21],[31],{"name":32,"affiliation":33,"role":34},"Wafia-Nadia Nibouche-Hattab, Professor of medicine","University of Algiers. Faculty of medicine","STUDY_DIRECTOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":13,"email":40},"Wafia- Nadia Nibouche - Hattab, Professor in medicine","CONTACT","+213-771-810-932","wani16000@yahoo.fr",[42,56],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":13},"Department of internal medicine, Ain-Taya's teaching Public hospital","ACTIVE_NOT_RECRUITING","Aïn Taya","Algiers Province","16019","Algeria","DZ",{"type":51,"coordinates":52},"Point",[53,54],3.28694,36.79333,{"lat":54,"lon":53},{"facility":57,"status":58,"city":59,"state":13,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Ain-Taya's Public Hospital","RECRUITING","Algiers",{"type":51,"coordinates":61},[62,63],3.08746,36.73225,{"lat":63,"lon":62},[66],{"name":67,"role":38,"phone":68,"phoneExt":13,"email":40},"Wafia Nadia WN Nibouche-Hattab, MD","213 771 810 032",{"type":70,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"PRINCIPAL_INVESTIGATOR","W.N. Nibouche-Hattab","Professor of Medicine","100604330","pregnancies-before-the-diagnosis-of-systemic-lupus-erythematosus-100604330",false,"NCT07148115","Pregnancies Before the Diagnosis of Systemic Lupus Erythematosus","Pregnancy Outcomes Prior to a Systemic Lupus Erythematosus Diagnosis","PREDILUP","Inclusion criteria:\n\n* Women of childbearing age with a history of at least one pregnancy\n* Pregnancy occurred before the diagnosis of LES.\n* LES was diagnosed after at least one pregnancy.\n* The subject is classified as having LES according to the 1997 ACR or EULAR 2019 criteria.\n\nExclusion criteria:\n\nLES was previously diagnosed prior to any conception.","FEMALE","18 Years","55 Years",{"count":85,"type":86},50,"ESTIMATED","OBSERVATIONAL","This is an observational, monocentric, retrospective cohort study. Its primary objective is to examine maternal and foetal outcomes in pregnancies that occurred before the diagnosis of systemic lupus erythematosus (SLE) in a group of female participants who were subsequently diagnosed with the condition.",[90,91],"Pregnancy Complications","SLE",[93,91,94],"Pregnancy","Obstetrical events","2025-12-26",{"date":97,"type":98},"2025-12-31","ACTUAL",{"date":100,"type":98},"2025-01-01",{"date":102,"type":86},"2026-04-30",{"name":5,"class":6},2]