[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100595191":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":49,"centralContacts":53,"locations":59,"responsibleParty":79,"collaborators":48,"id":81,"slug":82,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":48,"eligibilityCriteria":87,"healthyVolunteers":83,"sex":88,"minAge":89,"maxAge":48,"enrollmentInfo":90,"targetDuration":48,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":101,"overallStatus":62,"whyStopped":48,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"University of California, San Francisco","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"HEAL-ME and placebo supplementation","PLACEBO_COMPARATOR","Patients within this arm will be administered the HEAL-ME digital app and placebo supplementation daily",[13,14],"Behavioral: HEAL-ME digital app","Dietary Supplement: Placebo",{"label":16,"type":17,"description":18,"interventionNames":19},"HEAL-ME and creatine\u002Fwhey protein supplementation","EXPERIMENTAL","Patients within this arm will be administered the HEAL-ME digital app and whey protein\u002Fcreatine combination supplementation daily",[13,20,21],"Dietary Supplement: Creatine supplementation","Dietary Supplement: Whey protein supplementation",[23,31,38,44],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"BEHAVIORAL","HEAL-ME digital app","HEAL-ME is a digital prehabilitation app that provides semi-guided nutrition\u002Fexercise prehabilitation",[16,9],[29,30],"exercise","nutrition",{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"DIETARY_SUPPLEMENT","Creatine supplementation","Patients will take 5g creatine supplementation daily for 13 weeks",[16],[37],"Creatine",{"type":32,"name":39,"description":40,"armGroupLabels":41,"otherNames":42},"Whey protein supplementation","Patients will take 35g whey protein supplementation daily",[16],[43],"Whey",{"type":32,"name":45,"description":46,"armGroupLabels":47,"otherNames":48},"Placebo","Patients will be administered daily placebo supplementation.",[9],null,[50],{"name":51,"affiliation":5,"role":52},"Jennifer Lai, MD, MBA","PRINCIPAL_INVESTIGATOR",[54],{"name":55,"role":56,"phone":57,"phoneExt":48,"email":58},"Melinda Wang, MD, MHS","CONTACT","415-476-2777","melinda.wang3@ucsf.edu",[60],{"facility":61,"status":62,"city":63,"state":64,"zip":65,"country":66,"countryCode":67,"cosmosGeoPoint":68,"geoPoint":73,"contacts":74},"University of California San Francisco","RECRUITING","San Francisco","California","94143","United States","US",{"type":69,"coordinates":70},"Point",[71,72],-122.41942,37.77493,{"lat":72,"lon":71},[75,76,77],{"name":55,"role":56,"phone":57,"phoneExt":48,"email":58},{"name":51,"role":52,"phone":48,"phoneExt":48,"email":48},{"name":55,"role":78,"phone":48,"phoneExt":48,"email":48},"SUB_INVESTIGATOR",{"type":80,"investigatorFullName":48,"investigatorTitle":48,"investigatorAffiliation":48,"oldNameTitle":48,"oldOrganization":48},"SPONSOR","100595191","prehab-and-creatinewhey-supplementation-in-frailty-among-patients-with-cirrhosis-100595191",false,"NCT07029243","Prehab and Creatine\u002FWhey Supplementation in Frailty Among Patients With Cirrhosis","Physical Prehabilitation With and Without Creatine\u002FWhey Protein Supplementation Effects on Frailty In Patients With Cirrhosis","Inclusion Criteria:\n\n* Confirmed diagnosis of cirrhosis by ICD-10 code, liver biopsy, abdominal imaging, or transient elastography\n* Access to digital device and internet at home\n* Ability to provide written informed consent before any study-related activities\n* Ability to remain in study for at least 3 months\n\nExclusion Criteria:\n\n* Allergy to milk protein\n* On hemodialysis\n* No English language proficiency\n* Presence of condition or abnormality that in opinion of the Investigator will compromise safety of the patient or quality of the data\n* Concomitant severe underlying systemic illness that in the opinion of the Investigator would interfere with completion of study\n* Pregnant, breastfeeding, or intention of becoming pregnant during study time frame","ALL","18 Years",{"count":91,"type":92},100,"ESTIMATED","INTERVENTIONAL",[95],"NA","Frailty and muscle health are important for patients with chronic liver disease. This study looks at the use of a digital prehabilitation app (HEAL-ME) plus creatine and whey protein combination supplementation on maintaining muscle health in patients with liver disease. The investigators anticipate that this combination of supplementation and nutrition\u002Fexercise prehabilitation app will maintain muscle health in patients with liver disease.",[98,99,100],"Cirrhosis","Frailty","Sarcopenia",[102,103,104,105,106,107],"cirrhosis","liver","muscle","creatine","whey protein","frailty","2026-07-13",{"date":110,"type":111},"2026-07-15","ACTUAL",{"date":113,"type":111},"2026-04-15",{"date":115,"type":92},"2026-12",{"name":5,"class":6},1]