[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100656362":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":13,"studyPopulation":13,"armGroups":20,"interventions":27,"overallOfficials":13,"centralContacts":13,"locations":13,"responsibleParty":33,"collaborators":13,"id":37,"slug":38,"hasResults":39,"nctId":40,"briefTitle":41,"officialTitle":42,"acronym":13,"eligibilityCriteria":43,"healthyVolunteers":39,"sex":44,"minAge":45,"maxAge":13,"enrollmentInfo":46,"targetDuration":13,"studyType":49,"phases":50,"briefSummary":51,"conditions":52,"keywords":57,"overallStatus":65,"whyStopped":13,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":13},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Number of Participants Achieving Defined Grades of Tumor Devascularization","Tumor devascularization is determined by comparing post-embolization digital subtraction angiography (DSA) or CT angiography against baseline diagnostic imaging. Participants are categorized into three predefined grades based on devascularization of tumor vascular blush: poor (\\\u003C50%), moderate (50% to 80%), or good\u002Fcomplete (\\>80%).","24 hours post-embolization",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":13,"primaryPurpose":17,"observationalModel":13,"timePerspective":13,"maskingInfo":18},"NA","SINGLE_GROUP","TREATMENT",{"masking":19,"maskingDescription":13,"whoMasked":13},"NONE",[21],{"label":22,"type":23,"description":24,"interventionNames":25},"Preoperative Embolization and Surgical Resection","EXPERIMENTAL","Participants undergo pre-procedural neurological and imaging assessment, followed by diagnostic digital subtraction angiography (DSA) to identify tumor-feeding vessels. Super-selective microcatheterization is performed to deliver embolic agents (polyvinyl alcohol \\[PVA\\] particles, Onyx, or microcoils) for tumor devascularization. Post-embolization devascularization is evaluated by repeat DSA\u002FCT, followed by microsurgical tumor resection within 24 to 72 hours.",[26],"Procedure: Preoperative Endovascular Embolization",[28],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":13},"PROCEDURE","Preoperative Endovascular Embolization","Diagnostic cerebral digital subtraction angiography (DSA) is performed to identify tumor-feeding arteries and exclude dangerous anastomoses. Super-selective microcatheterization is then conducted to deliver embolic materials (polyvinyl alcohol \\[PVA\\] particles, Onyx, or microcoils) directly into the tumor vasculature. Tumor devascularization is quantified via post-procedural DSA\u002FCT (\\\u003C50%, 50-80%, or \\>80%). Following endovascular devascularization, patients undergo microsurgical tumor resection within 24 to 72 hours.",[22],{"type":34,"investigatorFullName":35,"investigatorTitle":36,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"PRINCIPAL_INVESTIGATOR","Sara Bakhet Abd Elrassol Saleh","Resident of Diagnostic and Interventional Radiology","100656362","preoperative-embolization-for-highly-vascular-brain-tumors-100656362",false,"NCT07823985","Preoperative Embolization for Highly Vascular Brain Tumors","Preoperative Embolization for Highly Vascularised Intracranial Tumors","Inclusion Criteria:\n\n* Diagnosis of a hypervascular brain tumor (e.g., meningioma, hemangioblastoma, or hypervascular metastasis) confirmed by contrast-enhanced MRI or CT\n* Scheduled for preoperative endovascular embolization followed by microsurgical resection\n\nExclusion Criteria:\n\n* Severe, uncorrected coagulopathy\n* Severe allergy to iodinated contrast media\n* Severe renal insufficiency (estimated glomerular filtration rate \\[eGFR\\] \\\u003C 30 mL\u002Fmin\u002F1.73 m²)\n* Absence of safe arterial access\n* Absence of identifiable tumor-feeding vessels suitable for selective microcatheterization","ALL","18 Years",{"count":47,"type":48},55,"ESTIMATED","INTERVENTIONAL",[15],"Highly vascular brain tumors, including meningiomas, hemangioblastomas, and certain metastases, have a rich blood supply that can lead to substantial blood loss and technical difficulties during surgical removal. Preoperative endovascular embolization is an adjunctive, catheter-based procedure used to block the feeding blood vessels of the tumor before surgery, aiming to reduce intraoperative bleeding and facilitate safer tumor resection.\n\nThe primary purpose of this study is to evaluate the technical feasibility, safety, and effectiveness of preoperative endovascular embolization in patients with highly vascular intracranial tumors.\n\nParticipants enrolled in this prospective study will undergo:\n\n1. Pre-procedural neurological and diagnostic cross-sectional imaging (contrast-enhanced MRI or CT angiography).\n2. Diagnostic digital subtraction angiography (DSA) to map tumor-feeding arteries, followed by super-selective catheterization to deliver embolic materials (polyvinyl alcohol particles, Onyx, or microcoils).\n3. Microsurgical tumor resection within 24 to 72 hours following the embolization procedure.\n\nResearchers will assess the degree of tumor devascularization achieved, the volume of intraoperative blood loss, blood transfusion requirements, total surgical duration, extent of tumor resection, and the occurrence of any procedure-related complications.",[53,54,55,56],"Brain Neoplasms","Meningioma","Hemangioblastoma","Brain Metastases",[58,59,60,61,62,63,64],"Preoperative Embolization","Endovascular Embolization","Tumor Devascularization","Digital Subtraction Angiography","Intraoperative Blood Loss","Interventional Neuroradiology","Microsurgical Resection","NOT_YET_RECRUITING","2026-09-11",{"date":68,"type":69},"2026-09-17","ACTUAL",{"date":71,"type":48},"2026-10",{"date":73,"type":48},"2027-11",{"name":5,"class":6}]