[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654840":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":17,"studyPopulation":18,"armGroups":19,"interventions":13,"overallOfficials":13,"centralContacts":23,"locations":29,"responsibleParty":47,"collaborators":13,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":13,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":13,"enrollmentInfo":60,"targetDuration":13,"studyType":63,"phases":13,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":32,"whyStopped":13,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Occurrence of Post-Induction Hemodynamic Vulnerability","Post-induction hemodynamic vulnerability will be defined as the occurrence of at least one mean arterial pressure (MAP) measurement ≤65 mmHg after induction of general anesthesia and before surgical incision. MAP will be assessed using standard intraoperative hemodynamic monitoring.","From induction of general anesthesia to surgical incision, up to 20 minutes",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":16,"maskingInfo":13},"COHORT","PROSPECTIVE","This is a prospective, observational, non-interventional study involving adult patients undergoing elective major oncologic surgery under general anesthesia. The study is designed to evaluate the relationship between the preoperative neutrophil percentage-to-albumin ratio (NPAR) and post-induction hemodynamic vulnerability.\n\nA total of 220 patients are planned to be enrolled using consecutive sampling. Eligible participants will be adults aged 18 years or older who are scheduled for elective major oncologic surgery under general anesthesia, have available preoperative complete blood count and serum albumin measurements, and undergo standard hemodynamic monitoring.\n\nNPAR will be calculated by dividing the preoperative neutrophil percentage by the serum albumin concentration in g\u002FdL. Demographic characteristics, ASA physical status, comorbidities, preoperative laboratory values, baseline hemodynamic measurements, induction-related data, intraoperative fluid administration, and vasopressor use and doses will be recorded prospectively.\n\nHemodynamic measurements will be evaluated from induction of general anesthesia until surgical incision, with a maximum observation period of 20 minutes. Participants will be classified according to the presence or absence of post-induction hemodynamic vulnerability.\n\nThe study will not alter routine anesthetic or surgical management. No additional medication, laboratory test, invasive procedure, or treatment modification will be performed for research purposes. Anesthetic agents, fluid therapy, and vasopressor administration will be determined by the responsible anesthesia team according to routine clinical practice.\n\nThe predictive performance of NPAR will be evaluated using receiver operating characteristic curve analysis and the area under the curve. Multivariable logistic regression analysis will be used to examine the association between NPAR and post-induction hemodynamic vulnerability while accounting for relevant clinical variables.","The study population will consist of adult patients aged 18 years or older who are scheduled to undergo elective major oncologic surgery under general anesthesia. Eligible participants must have available preoperative complete blood count and serum albumin measurements and undergo standard intraoperative hemodynamic monitoring. Patients will be enrolled consecutively at the study center. Individuals undergoing emergency surgery or presenting with preoperative hemodynamic instability, vasopressor or inotropic support, sepsis or active infection, hematologic malignancy, advanced cardiac, renal, or hepatic failure, pregnancy, or missing laboratory data will be excluded.",[20],{"label":21,"type":13,"description":22,"interventionNames":13},"Major Oncologic Surgery Cohort","Adult patients undergoing elective major oncologic surgery under general anesthesia will be prospectively enrolled. Preoperative neutrophil percentage-to-albumin ratio (NPAR) will be calculated from routine laboratory measurements. Hemodynamic data will be recorded from induction of general anesthesia until surgical incision, for a maximum of 20 minutes, to evaluate post-induction hemodynamic vulnerability. No research-specific intervention or modification of routine anesthetic management will be performed.",[24],{"name":25,"role":26,"phone":27,"phoneExt":13,"email":28},"Mustafa Kemal SAHIN, M.D","CONTACT","+5075800976","Mksahin@msn.com",[30],{"facility":31,"status":32,"city":33,"state":34,"zip":13,"country":35,"countryCode":13,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Dr. Abdurrahman Yurtaslan Ankara Oncology Hospital","RECRUITING","Ankara","Yeni̇mahalle","Turkey (Türkiye)",{"type":37,"coordinates":38},"Point",[39,40],32.85427,39.91987,{"lat":40,"lon":39},[43],{"name":44,"role":26,"phone":45,"phoneExt":13,"email":46},"Mustafa Kemal Şahin","+905075800976","mksahin@msn.com",{"type":48,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"PRINCIPAL_INVESTIGATOR","Mustafa Kemal ŞAHİN","Principal Investigator","100654840","preoperative-neutrophil-to-albumin-ratio-and-post-induction-hemodynamic-vulnerability-in-major-oncologic-surgery-100654840",false,"NCT07804706","Preoperative Neutrophil-to-Albumin Ratio and Post-Induction Hemodynamic Vulnerability in Major Oncologic Surgery","Preoperative Neutrophil Percentage-to-Albumin Ratio as a Predictor of Post-Induction Hemodynamic Vulnerability in Major Oncologic Surgery","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for elective major oncologic surgery\n* Undergoing surgery under general anesthesia\n* Availability of preoperative complete blood count and serum albumin -measurements\n* Standard hemodynamic monitoring\n* Provision of written informed consent for participation in the study\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Emergency surgery\n* Preoperative hemodynamic instability\n* Preoperative vasopressor or inotropic support\n* Sepsis or active infection\n* Hematologic malignancy\n* Advanced cardiac, renal, or hepatic failure\n* Pregnancy\n* Missing preoperative laboratory data -Inability to complete the 20-minute post-induction evaluation period-","ALL","18 Years",{"count":61,"type":62},200,"ESTIMATED","OBSERVATIONAL","This prospective observational study aims to evaluate whether the preoperative neutrophil percentage-to-albumin ratio (NPAR) is associated with post-induction hemodynamic vulnerability in adult patients undergoing elective major oncologic surgery under general anesthesia.\n\nNPAR will be calculated from routine preoperative laboratory results by dividing the neutrophil percentage by the serum albumin level. No additional laboratory tests, medications, invasive procedures, or changes in anesthesia management will be performed for the purposes of the study.\n\nDemographic characteristics, preoperative laboratory values, anesthetic data, and hemodynamic measurements will be recorded prospectively. Hemodynamic status will be evaluated during the period between induction of general anesthesia and surgical incision, with a maximum observation period of 20 minutes. Vasopressor use and administered doses will also be recorded.\n\nThe study will assess the ability of preoperative NPAR to identify patients who may be more susceptible to early hemodynamic instability following induction of general anesthesia.",[66,67],"Hemodynamic Instability","Post-induction Hypotension (PIH)",[69,70,71,72],"Neutrophil Percentage-to-Albumin Ratio","Post-Induction Hypotension","Hemodynamic Vulnerability","Major Oncologic Surgery","2026-09-03",{"date":75,"type":76},"2026-09-09","ACTUAL",{"date":78,"type":76},"2026-09-01",{"date":80,"type":62},"2026-12-15",{"name":5,"class":6},1]