[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649483":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":15,"collaborators":10,"id":19,"slug":20,"hasResults":21,"nctId":22,"briefTitle":23,"officialTitle":24,"acronym":10,"eligibilityCriteria":25,"healthyVolunteers":21,"sex":26,"minAge":27,"maxAge":10,"enrollmentInfo":28,"targetDuration":10,"studyType":31,"phases":10,"briefSummary":32,"conditions":33,"keywords":36,"overallStatus":40,"whyStopped":10,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":10},{"fullName":5,"class":6},"Assiut University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Eosinophilic COPD",null,"Patients \\> 40 years of age with a confirmed diagnosis of COPD (according to GOLD 2026 guidelines) presenting with an acute exacerbation, who are identified as having a blood eosinophil count \\> 300 cells\u002FµL.",{"label":13,"type":10,"description":14,"interventionNames":10},"Non-eosinophilic COPD","Patients \\> 40 years of age with a confirmed diagnosis of COPD (according to GOLD 2026 guidelines) presenting with an acute exacerbation, who do not meet the criteria for eosinophilia (blood eosinophil count ≤ 300 cells\u002FµL).",{"type":16,"investigatorFullName":17,"investigatorTitle":18,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Hagar Awadallah Fahmy Ragheb","Resident at Chest Diseases Department","100649483","prevalence-and-clinical-outcome-of-eosinophilic-copd-100649483",false,"NCT07734883","Prevalence and Clinical Outcome of Eosinophilic COPD","Prevalence and Clinical Outcome of Eosinophilic COPD at Assiut University","Inclusion Criteria:\n\n* Patients aged \\> 40 years.\n* Confirmed diagnosis of COPD according to GOLD 2026 guidelines.\n* Presented with acute exacerbation of COPD (AECOPD) characterized by the onset or worsening of at least two symptoms (cough, phlegm, purulent sputum, wheezing, or dyspnea) persisting for a minimum of 48 hours, excluding other potential causes, such as left or right cardiac dysfunction, pulmonary embolism, pneumothorax, pleural effusion, arrhythmia and other related diseases.\n\nExclusion Criteria:\n\n* Patients with asthma or asthma-COPD overlap.\n* Patients who need ICU admission.\n* Patients receiving systemic corticosteroids within the previous 4 weeks.\n* Hematological disorders affecting eosinophil count.\n* Active pulmonary tuberculosis.\n* Parasitic infections confirmed by stool analysis.","ALL","40 Years",{"count":29,"type":30},70,"ESTIMATED","OBSERVATIONAL","Chronic Obstructive Pulmonary Disease (COPD) is a lung condition characterized by chronic breathing symptoms and progressive airflow blockages. A specific type of COPD, known as eosinophilic COPD, involves higher levels of white blood cells called eosinophils and is known to influence disease outcomes and treatment responses. Currently, there is limited data regarding the prevalence and clinical outcomes of eosinophilic COPD in Upper Egypt, particularly among patients at Assiut University Hospitals.\n\nThe main objective of this prospective observational study is to determine how common eosinophilic COPD is among patients experiencing an acute worsening of their COPD symptoms (an exacerbation) at Assiut University Hospitals. The study also aims to evaluate the clinical outcomes associated with this specific phenotype.\n\nResearchers will observe patients over the age of 40 with a confirmed COPD diagnosis who are admitted to the hospital for an acute exacerbation. As part of their standard hospital care, participants will undergo routine clinical assessments, including a review of their medical history, physical examinations, lung function tests (spirometry), and standard blood tests to measure their blood eosinophil count.\n\nThe study will compare patients with eosinophilic COPD to those with non-eosinophilic COPD. Researchers will specifically evaluate differences in the severity of the exacerbation, the duration of the hospital stay, and the need for ventilator support. The findings aim to contribute to better, more personalized treatment strategies and improved clinical outcomes for COPD patients in the region.",[34,9,35],"Chronic Obstructive Pulmonary Disease (COPD)","Acute Exacerbation of Chronic Obstructive Pulmonary Disease",[9,37,38,39],"COPD Exacerbation","Blood Eosinophils","Sputum Eosinophilia","NOT_YET_RECRUITING","2026-07-25",{"date":43,"type":44},"2026-07-29","ACTUAL",{"date":46,"type":30},"2026-08",{"date":48,"type":30},"2027-09",{"name":5,"class":6}]