[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651462":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":29,"locations":11,"responsibleParty":39,"collaborators":11,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":43,"sex":49,"minAge":50,"maxAge":11,"enrollmentInfo":51,"targetDuration":11,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":63,"whyStopped":11,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":11},{"fullName":5,"class":6},"Centre Hospitalier Universitaire de Nice","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Ischemic Preconditioning (RIPC)","EXPERIMENTAL",null,[13],"Procedure: Remote Ischemic Preconditioning",{"label":15,"type":16,"description":11,"interventionNames":17},"Sham Procedure","PLACEBO_COMPARATOR",[18],"Procedure: Sham Ischemic Preconditioning",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"PROCEDURE","Remote Ischemic Preconditioning","Three cycles of lower-limb ischemia and reperfusion using a blood pressure cuff inflated to 20 mmHg above systolic blood pressure for 5 minutes followed by 5 minutes of reperfusion. The procedure is performed every two days from day 2 to day 10 after aneurysmal subarachnoid hemorrhage.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Sham Ischemic Preconditioning","Identical procedure to the experimental arm, except the cuff is inflated to only 30 mmHg, insufficient to induce ischemia, giving the sensation of pressure without therapeutic effect. Performed every two days from day 2 to day 10 post-hemorrhage.",[15],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},"Jacques Sedat, MD","CONTACT","+33 4 92 03 38 07","sedat.j@chu-nice.fr",{"name":36,"role":32,"phone":37,"phoneExt":11,"email":38},"Eve Ledoux","+33 4 92 03 27 29","ledoux.e@chu-nice.fr",{"type":40,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100651462","prevention-of-ischemia-in-aneurysmal-subarachnoid-hemorrhage-through-remote-ischemic-preconditioning-100651462",false,"NCT07761520","Prevention of Ischemia in Aneurysmal Subarachnoid Hemorrhage Through Remote Ischemic Preconditioning","Remote Ischemic Preconditioning (RIPC) and Aneurysmal Subarachnoid Hemorrhage (SAH)","HMA","Inclusion Criteria:\n\n* Age over 18 years\n* Hospitalization for aneurysmal subarachnoid hemorrhage confirmed by CT scan and\u002For lumbar puncture\n* Confirmation of intracranial aneurysm by CT angiography and\u002For cerebral angiography\n* Written informed consent obtained from the patient or legal representative\n* Affiliation to a social security system\n\nExclusion Criteria:\n\n* Skin, orthopedic, or vascular conditions of the limbs contraindicating ischemic preconditioning (e.g., ulcers, fractures, deep vein thrombosis)\n* Pregnancy\n* Withdrawal of informed consent","ALL","18 Years",{"count":52,"type":53},140,"ESTIMATED","INTERVENTIONAL",[56],"NA","Aneurysmal subarachnoid hemorrhage (SAH) is a severe form of stroke caused by bleeding around the brain. Despite early treatment of the initial hemorrhage, many patients develop delayed cerebral ischemia several days later, which is a major cause of neurological disability, cognitive impairment, and mortality. Current preventive and therapeutic strategies are only partially effective, highlighting the need for new treatment approaches.\n\nThis study investigates a simple, non-invasive technique called remote ischemic preconditioning (RIPC). RIPC consists of brief, repeated cycles of limb ischemia and reperfusion induced by a blood pressure cuff. RIPC is thought to activate endogenous protective mechanisms that may improve the brain's tolerance to ischemia. Although beneficial effects have been reported in experimental models and cardiovascular diseases, its clinical efficacy in aneurysmal SAH remains uncertain.\n\nIn this randomized, controlled, single-blinded, multicenter study, adult patients admitted with aneyrysmal SAH will be randomly assigned to receive RIPC or a sham procedure. The RIPC group will undergo cycles of brief lower-limb ischemia using a pressure cuff, while the sham group will receive an identical procedure without inducing ischemia. Patients and neurologists assessing outcomes will remain blinded to group allocation.\n\nThe intervention will be performed every two days from day 2 to day 10 after hemorrhage. Neurological outcome will be assessed at 3 months using the modified Rankin Scale. Secondary outcomes include mortality at 3 months, long-term neurological and cognitive function outcomes at 12 months, and the incidence of adverse events related to the procedure.\n\nIf effective, RIPC could become a simple, low-cost, widely accessible method to reduce disability after SAH. The results may help improve future treatment strategies for this severe condition.",[59],"Aneurysmal Subarachnoid Hemorrhage",[61,62],"Aneurysmal Subarachnoid Hemorrhage (aSAH)","Remote Ischemic Preconditioning (RIPC)","NOT_YET_RECRUITING","2026-08-11",{"date":66,"type":67},"2026-08-12","ACTUAL",{"date":69,"type":53},"2026-09",{"date":71,"type":53},"2029-09",{"name":5,"class":6}]